Results 41 to 50 of about 57,119 (251)

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Histomorphological observation of surgical debridement combined with negative pressure therapy in treatment of diabetic foot

Chinese Journal of Traumatology, 2017
Purpose: To further study the mechanism of epithelization on the fascia side of the flap after surgical incision and the treatment of the negative pressure therapy.
Jiao-Yun Dong, Fei Song, Chun Qing, Shu-Liang Lu   +3 more
doaj   +1 more source

Clinical and Prognostic Significances of Cytokeratin 19 and KIT Expression in Surgically Resectable Pancreatic Neuroendocrine Tumors [PDF]

Journal of Pathology and Translational Medicine, 2015
Background: Pancreatic neuroendocrine tumors (PanNETs) are malignant endocrine neoplasms that present diverse clinical behaviors. Therefore, identification of biomarkers of PanNETs is important for stratification of the prognosis of PanNET patients ...
Eun-Mi Son, Joo Young Kim, Soyeon An, Ki-Byung Song, Song Cheol Kim, Eunsil Yu, Seung-Mo Hong   +6 more
doaj   +1 more source

Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies.

Histology and histopathology, 2012
Human epithelium contains keratin, which is expressed during differentiation. Depending on the target cell type, different types of keratin are expressed, and their alterations seem to represent changes in cell properties. The basal cells of oral epithelium express keratin 5 (K5), K14, K15 and K19, but their alterations in tumors are unclear.
Khanom, Rumana, Sakamoto, Kei, Kumar Pal, Samir, Shimada, Yasuyuki, Morita, Kei-ichi, Omura, Ken, Miki, Yoshio, Yamaguchi, Akira   +7 more
openaire   +3 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Expression of keratins 8, 18, and 19 in epithelia of atrophic oral lichen planus [PDF]

European Journal of Oral Sciences, 2020
Keratins form intermediate filaments of the cytoskeleton in keratinocytes and have roles in cell structure, signaling, intracellular transport, and cell death. Oral lichen planus (OLP) is an oral inflammatory disease with derangements in basal keratinocytes and disruption of the basal membrane.
Olav Schreurs, Andreas Karatsaidis, Maria G. Balta, Bjarte Grung, Else K. B. Hals, Karl Schenck   +5 more
openaire   +4 more sources

Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients. [PDF]

PLoS ONE, 2013
BACKGROUND: Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients that have had an estrogen receptor (ER) positive primary tumor or metastatic lesions, however, approximately 20% of these patients do not ...
Anna Babayan, Juliane Hannemann, Julia Spötter, Volkmar Müller, Klaus Pantel, Simon A Joosse   +5 more
doaj   +1 more source

The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation

Cell Transplantation, 2021
When using human induced pluripotent stem cells (hiPSCs) to achieve hair follicle (HF) replacement, we found it best to emulate the earliest fundamental developmental processes of gastrulation, ectodermal lineage commitment, and dermogenesis.
Michel R. Ibrahim, Walid Medhat, Hasan El-Fakahany, Hamza Abdel-Raouf, Evan Y. Snyder   +4 more
doaj   +1 more source

MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels.

PLoS ONE, 2015
Three-dimensional (3D) cultures are increasing in use because of their ability to represent in vivo human physiology when compared to monolayer two-dimensional (2D) cultures.
Marguerite M Vantangoli, Samantha J Madnick, Susan M Huse, Paula Weston, Kim Boekelheide   +4 more
doaj   +1 more source

Keratin 19: Predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins

Journal of Investigative Dermatology, 1989
The type I keratin 19 is unusual in its tissue distribution in that under normal circumstances it does not seem to be restricted, as the other keratins are, to expression in either stratified or simple epithelia. In addition to the previously reported distribution of keratin 19 in human tissues, we have observed keratin 19 in epidermal basal cells, in ...
Stasiak, Pauline C., Purkis, Patricia E., Leigh, Irene M., Birgitte Lane, E.   +3 more
openaire   +2 more sources