Results 51 to 60 of about 57,119 (251)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Lung Cancer-Associated Keratin 19 Fragments: Development and Biochemical Characterisation of the New Serum Assay Enzymun-Test Cyfra 21–1

The International Journal of Biological Markers, 1994
From a panel of 4 murine monoclonal antibodies directed against keratin 19 various antibody combinations were evaluated in solid-phase enzyme-linked sandwich immunoassays for detection of soluble keratin 19 fragments in patient sera.
H. Bodenmüller, B. Ofenloch-Hähnle, E.B. Lane, A. Dessauer, V. Böttger, F. Donié   +5 more
doaj   +1 more source

Detection of lymph node metastasis in lung cancer patients using a one-step nucleic acid amplification assay: a single-centre prospective study

Journal of Translational Medicine, 2019
Background The use of one-step nucleic acid amplification (OSNA) allows for lymph node (LN) metastasis to be detected rapidly and accurately. We conducted a prospective single-centre clinical trial to evaluate OSNA assay in detecting LN metastasis of ...
María Escalante Pérez, María Teresa Hermida Romero, Begoña Otero Alén, Mónica Álvarez Martínez, Ricardo Fernández Prado, Mercedes de la Torre Bravos, Ángel Concha López   +6 more
doaj   +1 more source

Strain‐Programmable Luminescent Adhesive Patch With Tartrazine‐Mediated Optical Skin Clearing for Photochemical Tissue Bonding

Advanced Functional Materials, EarlyView.
We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim, Kyungjoo Jo, Kwanghyeon Park, Jun Hee Kim, Jong Hyeong Cho, Inhoo Choi, Sei Kwang Hahn   +6 more
wiley   +1 more source

Cross-talk between microRNA-let7c and transforming growth factor-β2 during epithelial-to-mesenchymal transition of retinal pigment epithelial cells [PDF]

International Journal of Ophthalmology, 2020
AIM: To explore the roles of microRNA-let7c (miR-let7c) and transforming growth factor-β2 (TGF-β2) and cellular signaling during epithelial-to-mesenchymal transition (EMT) of retinal pigment epithelial cells. METHODS: Retinal pigment epithelial (ARPE-19)
Qu-Zhen Deji, Feng Yan, Wang-Dui Zhaba, Ya-Jun Liu, Jie Yin, Zhen-Ping Huang   +5 more
doaj   +1 more source

Immune Cells Profiles in the Different Sites of COVID-19-Affected Lung Lobes in a Single Patient

Frontiers in Medicine, 2022
Whereas the COVID-19 disease pathophysiology is under investigation, it is important to identify the pathways of viral transmission and inflammation from the pre-illness to the disease-onset stages.
Sadahiro Iwabuchi, Kyohei Miyamoto, Mayuko Hatai, Yurina Mikasa, Masahiro Katsuda, Shin-ichi Murata, Toshikazu Kondo, Hiroki Yamaue, Shinichi Hashimoto   +8 more
doaj   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

The role of Grafting in Canal Wall down Mastoidectomy Comparative Study [PDF]

Zagazig University Medical Journal
Background: Radical mastoidectomy is the outstanding standard technique for management of cholesteatoma. Long term studies showed increasing incidence of discharging cavities .
essam mohammed, alaaedein farouk, Wael Alzamel   +2 more
doaj   +1 more source

Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. [PDF]

PLoS ONE, 2013
Epidermal squamous cell carcinoma is among the most common cancers in humans. These tumors are comprised of phenotypically diverse populations of cells that display varying potential for proliferation and differentiation. An important goal is identifying
Gautam Adhikary, Dan Grun, Candace Kerr, Sivaprakasam Balasubramanian, Ellen A Rorke, Mohan Vemuri, Shayne Boucher, Jackie R Bickenbach, Thomas Hornyak, Wen Xu, Matthew L Fisher, Richard L Eckert   +11 more
doaj   +1 more source

Keratin–Melanin Complexation Enables Robust, Delamination‐Resistant Feather‐Inspired Structural Color Coatings for Flexible and Curved Substrates

Advanced Materials Interfaces, EarlyView.
Providing mechanically robust structural color coating technology inspired by cooperative interactions in nature. The spatial arrangement of melanin particles within the keratin matrix generates angle‐independent structural colors. Diverse functional groups in keratin and melanin contribute to interparticle and substrate adhesion, resulting in the ...
Taisei Harada, Yui Maejima, Ryota Iwamori, Hideyuki Mitomo, Hirotoshi Tamayama, Shin‐ichi Takeda, Daisuke Unabara, Tasuku Hamaguchi, Koji Yonekura, Gen Morimoto, Hiroshi Fudouzi, Keiki Kishikawa, Michinari Kohri   +12 more
wiley   +1 more source