Results 11 to 20 of about 26,538 (309)

Expression of keratins, epidermal proteins and inflammatory cells in superficial pemphigus dogs [PDF]

Bulgarian Journal of Veterinary Medicine, 2018
Superficial pemphigus in dogs is an autoimmune skin disorder. The disease is characterised by the binding of auto-antibodies to desmosomal molecules including desmocollin-1, a major auto-antigen in dogs.
S. Theerawatanasirikul, A. Rungsipipat, W. Banlunara , P. Pongket   +3 more
doaj   +1 more source

Skin Keratins [PDF]

, 2016
Keratins comprise the type I and type II intermediate filament-forming proteins and occur primarily in epithelial cells. They are encoded by 54 evolutionarily conserved genes (28 type I, 26 type II) and regulated in a pairwise and tissue type-, differentiation-, and context-dependent manner.
Fengrong, Wang, Abigail, Zieman, Pierre A, Coulombe   +2 more
openaire   +2 more sources

A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury

EBioMedicine, 2016
A validated animal model would assist with research on the immunological consequences of the chronic expression of stress keratins KRT6, KRT16, and KRT17, as observed in human pre-malignant hyperproliferative epithelium.
Samal Zhussupbekova, Rohit Sinha, Paula Kuo, Paul F. Lambert, Ian H. Frazer, Zewen K. Tuong   +5 more
doaj   +1 more source

Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity

Human Genomics, 2018
Background Mutations in keratin proteins have been vastly associated with a wide array of genodermatoses; however, mutations of keratins in psoriasis have not been fully investigated.
Tamilselvi Elango, Jingying Sun, Caihong Zhu, Fusheng Zhou, Yaohua Zhang, Liangdan Sun, Sen Yang, Xuejun Zhang   +7 more
doaj   +1 more source

Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix

Cancer Medicine, 2020
Aims The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a dynamic area where switches from glandular into squamous epithelium can be recognized, new ...
Jobran M. Moshi, Klaas J. Hoogduin, Monique Ummelen, Mieke E. R. Henfling, Manon vanEngeland, Kim A. D. Wouters, Hans Stoop, Imke Demers, Leendert H. J. Looijenga, Frans C. S. Ramaekers, Anton N. H. Hopman   +10 more
doaj   +1 more source

Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality

Frontiers in Immunology, 2018
Thymic epithelial cells are one of the main components of the thymic microenvironment required for T-cell development. In this work, we describe an efficient method free of enzymatic and Facs-sorted methods to culture human medullary thymic epithelial ...
José A. Villegas, Angeline Gradolatto, Frédérique Truffault, Régine Roussin, Sonia Berrih-Aknin, Rozen Le Panse, Nadine Dragin, Nadine Dragin   +7 more
doaj   +1 more source

Antimicrobial Photodynamic Therapy Mediated by Curcumin-Loaded Polymeric Nanoparticles in a Murine Model of Oral Candidiasis

Molecules, 2018
Antimicrobial photodynamic therapy (aPDT) has been proposed as an alternative method for oral candidiasis (OC), while nanocarriers have been used to improve the water solubility of curcumin (CUR).
Vinicius Tatsuyuji Sakima, Paula Aboud Barbugli, Paulo Sérgio Cerri, Marlus Chorilli, Juliana Cabrini Carmello, Ana Cláudia Pavarina, Ewerton Garcia de Oliveira Mima   +6 more
doaj   +1 more source

Traceless Targeting and Isolation of Gene-Edited Immortalized Keratinocytes from Epidermolysis Bullosa Simplex Patients

Molecular Therapy: Methods & Clinical Development, 2017
Epidermolysis bullosa simplex (EBS) is a blistering skin disease caused by dominant-negative mutations in either KRT5 or KRT14, resulting in impairment of keratin filament structure and epidermal fragility.
Magomet Aushev, Ulrich Koller, Claudio Mussolino, Toni Cathomen, Julia Reichelt   +4 more
doaj   +1 more source

Keratin 17 Suppresses Cell Proliferation and Epithelial-Mesenchymal Transition in Pancreatic Cancer

Frontiers in Medicine, 2020
Keratin 17 (K17), a member of type I acidic epithelial keratin family, has been reported to be upregulated in many malignant tumors and to be involved in promoting the development of tumors.
Yong Zeng, Min Zou, Yan Liu, Keting Que, Yunbing Wang, Changan Liu, Jianpin Gong, Yu You   +7 more
doaj   +1 more source

Carbamoylated Nail Proteins as Assessed by Near-Infrared Analysis Are Associated with Load of Uremic Toxins and Mortality in Hemodialysis Patients

Toxins, 2020
Carbamoylation is an important risk factor for accelerated atherogenesis and mortality in patients undergoing hemodialysis (HD). We intended to explore whether carbamoylation as assessed by near-infrared (NIR) analysis of nail proteins is associated with
Sander De Bruyne, Jonas Himpe, Sigurd E. Delanghe, Griet Glorieux, Wim Van Biesen, Marc L. De Buyzere, Marijn M. Speeckaert, Joris R. Delanghe   +7 more
doaj   +1 more source