Results 41 to 50 of about 28,856 (299)

Evaluation of expression of Toll-Like Receptors 7 and 9, proliferation, and cytoskeletal biomarkers in plaque and guttate psoriasis: A pilot morphological study

European Journal of Histochemistry, 2021
This pilot study was aimed at comparing TLR7/TLR9 expression, cytoskeletal arrangement, and cell proliferation by indirect immunofluorescence in parallel lesional and non lesional skin samples of guttate psoriasis (PG) and psoriasis vulgaris (PV) in five
Francesca Prignano, Giulia Lombardo, Serena Indino, Federica Ricceri, Laura Cornaghi, Elena B. Donetti   +5 more
doaj   +1 more source

Regional variation in the flexural properties of the equine hoof wall [PDF]

, 2008
The equine hoof wall is a hard, keratinous structure that transmits forces generated when the hoof connects the ground to the skeleton of the horse. During locomotion the hoof capsule is known to deform, resulting in an inward curvature of the dorsal ...
A M Goodman, Bertram, Bertram, Butler, Dejardin, Douglas, Dyhre-Poulsen, Fraser, Hinterhofer, Jackson, Kasapi, Kasapi, Kasapi, Kasapi, L Haggis, Leach, Lungwitz, Newlyn, Niklas, Reilly, Sokal, Stump, Thomason, Vincent   +23 more
core   +1 more source

Bioprospecting keratinous materials

International Journal of Trichology, 2010
The concept of bioprospecting for bioactive peptides from keratin-containing materials such as wool, hair, skin and feathers presents an exciting opportunity for discovery of novel functional food ingredients and nutraceuticals, while value-adding to cheap and plentiful natural sources. The published literature reports multiple examples of proline-rich
Jones, LN, Sinclair, RD, Carver, J, Ecroyd, H, Lui, Y, Bennett, LE   +5 more
openaire   +3 more sources

Obtaining human hair keratin-based films and their characteristics

Біологічні студії, 2021
Background. Keratins are natural biopolymers with a wide range of applications in the field of biotechnology. Materials and Methods. Extraction of keratins was performed by a modified Nakamura method using 250 mM DTT.
V. V. Mykhaliuk, V. V. Havryliak
doaj   +1 more source

Fossilized skin reveals coevolution with feathers and metabolism in feathered dinosaurs and early birds [PDF]

, 2018
Feathers are remarkable evolutionary innovations that are associated with complex adaptations of the skin in modern birds. Fossilised feathers in non-avian dinosaurs and basal birds provide insights into feather evolution, but how associated ...
Benton, Michael J., Foley, Tara, Hone, David W. E., Johnson, Diane, Kearns, Stuart L., McNamara, Maria E., Orr, Patrick J., Rogers, Chris S., Toulouse, André, Xu, Xing, Zhang, Fucheng, Zhou, Zhonghe   +11 more
core   +5 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Rational design of water‐soluble, homotypic keratins self‐assembly with enhanced bioactivities

Aggregate
Recombinant keratins possess strong hemostatic and wound healing properties but suffer from poor water solubility that restricts their bioactivities in biomedical applications. Herein, we report the rational design and synthesis of water‐soluble keratins
Jie Chen, Yumei Wang, Jia Deng, Rui Qing, Yaxi Yang, Xiaoliang Chen, Zibin Gao, Bochu Wang, Shilei Hao   +8 more
doaj   +1 more source