Results 51 to 60 of about 37,023 (241)

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Analysis of the human diseasome reveals phenotype modules across common, genetic, and infectious diseases [PDF]

, 2014
Phenotypes are the observable characteristics of an organism arising from its response to the environment. Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are signs
Gkoutos, Georgios V, Hoehndorf, Robert, Schofield, Paul N   +2 more
core   +2 more sources

Multi‐Institutional Assessment of Dental Students' Knowledge in Oral Soft Tissue Pathological Entities

Journal of Dental Education, EarlyView.
ABSTRACT Objectives This study provides a descriptive, multi‐institutional comparison of dental students' recognition accuracy and management decisions of oral soft tissue pathological entities across four US dental schools. While prior single‐institution studies have evaluated diagnostic ability, this work provides a multi‐institutional comparison to ...
Nicole McKee, Paul Edwards, Gerardo Maupomé, George Eckert, Celine Joyce Cornelius Timothius, Karim El Kholy, Jennifer Chang, Vanchit John   +7 more
wiley   +1 more source

Dysplastic nevus associated with seborrheic keratosis [PDF]

Anais Brasileiros de Dermatologia, 2014
Seborrheic keratosis is a common skin lesion which may coincidentally be associated melanocytic nevi. The authors describe a case of dysplastic nevus associated with seborrheic keratosis and discuss the clinical, dermoscopic, and histological findings of
Luciane Francisca Fernandes Botelho, Nilceo Schwery Michalany, Milvia Maria Simoes e Silva Enokihara, Sergio Henrique Hirata   +3 more
doaj   +1 more source

Contribution to characterization of skin field cancerization activity: morphometric, chromatin texture, proliferation, and apoptosis aspects, [PDF]

Anais Brasileiros de Dermatologia, 2020
Background: A skin field cancerization is a cutaneous area with subclinical changes resultant from chronic sun exposure, with a higher predisposition to development of pre-neoplastic and neoplastic lesions.
Anna Carolina Miola, Mariana Anteghini Castilho, Juliano Vilaverde Schmitt, Mariangela Esther Alencar Marques, Helio Amante Miot   +4 more
doaj   +1 more source

Performance of a Deep Learning Algorithm for Melanoma Classification Across Diverse Dermoscopic and Tele‐Dermatology Datasets

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Early detection of melanoma significantly boosts patient survival rates. Deep learning has demonstrated dermatologist‐level accuracy in assessing pigmented skin lesions by analysing images at the pixel level. However, these neural networks may face challenges with ‘real‐life’ images due to limited training data and image artefacts ...
Marianne Zanchetta, Fanny Gohard, Casandra Coltoiu, Sarah Le Naour, Marie Le Moigne, Valérie Pham‐Huu, Nicole Cochelin, Edmond Demoulins, Bryan Boule, Thibault Maho, Léonie Schroder, Nicolas Diris, Gaëlle Quereux, Brigitte Dreno, Lise Boussemart, Javier Saenz   +15 more
wiley   +1 more source

Reduced Visibility of Pigment Network Under Sub‐UV Reflectance Dermatoscopy Compared to Polarised Dermatoscopy: A Novel Diagnostic Clue to Differentiate Melanomas From Nevi

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Melanoma accounts for more than 75% of skin cancer‐related mortality. Dermatoscopy is an evidence‐based technique for earlier detection, yet differentiating melanocytic lesions remains challenging. Sub‐UV reflectance dermatoscopy (sUVRD) uses purple light (405 nm) to visualise chromophore distribution in the skin.
L. Dupont, P. Pietkiewicz, J. Anriot, P. Greco, A. Petiot‐Walch, C. Coste, E. Aurambout, S. Darnis, M. Amini‐Adle, L. Thomas   +9 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Generalized keratosis pilaris induced by testosterone injections in patient with CHARGE syndrome

Dermatology Reports, 2023
Keratosis pilaris (KP) is a common disorder of follicular keratinization characterized by keratotic follicular papules with varying degrees of perifollicular erythema.
Fares A. Alkhayal, Rima Bin Fadliah, Sarah Alasgah, Raed Almutiri, Yasser Alqubaisy   +4 more
doaj   +1 more source