Results 1 to 10 of about 235,967 (343)
The collective lie in ketamine therapy: a call to realign clinical practice with neurobiology [PDF]
Frontiers in PsychiatryIn recent years, ketamine therapy has become increasingly entangled with psychedelic culture, leading to widespread misinterpretation of its therapeutic mechanism.
Charles Miller +2 more
doaj +2 more sources
International Review of Psychiatry, 2021 Over the last two decades, the dissociative anaesthetic agent ketamine, an uncompetitive N-Methyl-D-Aspartate (NMDA) receptor antagonist, has emerged as a novel therapy for treatment-resistant depression (TRD), demonstrating rapid and robust antidepressant effects within hours of administration.
James M. Stone +3 more
openaire +4 more sources
Outcomes and physiologic responses associated with ketamine administration after traumatic brain injury in the United States and Canada: a retrospective analysis [PDF]
Journal of Trauma and Injury, 2023 Purpose Ketamine has historically been contraindicated in traumatic brain injury (TBI) due to concern for raising intracranial pressure. However, it is increasingly being used in TBI due to the favorable respiratory and hemodynamic properties.
Austin J. Peters +4 more
doaj +1 more source
Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses
Frontiers in Psychiatry, 2023 Ketamine-assisted psychotherapy is a promising new treatment for a variety of mental disorders of adolescence. There is currently an adolescent mental health crisis, with a high prevalence of disorders, diagnostic complexity, and many adolescents failing
Philip E. Wolfson +7 more
doaj +1 more source
Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
Neuropsychopharmacology, 2023 Ketamine is an open channel blocker of ionotropic glutamatergic N -Methyl- D -Aspartate (NMDA) receptors. The discovery of its rapid antidepressant effects in patients with depression and treatment-resistant depression fostered novel effective treatments
J. Krystal, E. Kavalali, L. Monteggia
semanticscholar +1 more source
Heliyon, 2023 Co-occurrence of posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) symptoms are particularly prevalent in the special operations forces' community, along with other related conditions (e.g., endocrine dysregulation, sleep disorders ...
Eugene Lipov +3 more
doaj +1 more source
Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb
Nature, 2023 The discrepancy between the short half-life of ketamine and its long-lasting effects is due to ketamine being trapped in NMDA receptors, and its release depends on neural activity in the lateral habenula.
Shuangshuang Ma +16 more
semanticscholar +1 more source
European psychiatry, 2022 Introduction Identifying a feasible model of chronic schizophrenia would be valuable for studying the possible underlying mechanism and to investigate emerging treatments.
D. Khalifa +3 more
semanticscholar +1 more source