Results 91 to 100 of about 345,134 (373)

Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats

Journal of Pharmacological Sciences, 2013
We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-
Kazumi Yoshizawa, Tomohisa Mori, Tamami Ueno, Mizuki Nishiwaki, Masahiro Shibasaki, Norifumi Shimizu, Minoru Narita, Tsutomu Suzuki   +7 more
doaj   +1 more source

Ketamine administration in healthy volunteers reproduces aberrant agency experiences associated with schizophrenia [PDF]

, 2011
Introduction. Aberrant experience of agency is characteristic of schizophrenia. An understanding of the neurobiological basis of such experience is therefore of considerable importance for developing successful models of the disease.
Absalom, Antony R., Adapa, Ram, Arana, Fernando S., Corlett, Philip R., de Wit, Sanne, Everitt, Jessica C., Fletcher, Paul C., Gardner, Jenny M., Haggard, Patrick, Moore, James W., Morgan, Hannah L., Pigott, Jennifer S., Turner, Danielle C.   +12 more
core   +2 more sources

Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective

Psychiatry and Clinical Neurosciences, 2019
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders. Approximately one‐third of the patients with MDD are treatment resistant to the current antidepressants.
K. Hashimoto
semanticscholar   +1 more source

Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms

Pharmacological Reports, 2021
Over the past 50 years, ketamine has solidified its position in both human and veterinary medicine as an important anesthetic with many uses. More recently, ketamine has been studied and used for several new indications, ranging from chronic pain to drug
S. Kohtala
semanticscholar   +1 more source

Plasma‐Polymerized Nanoparticles Presenting Fibrillin‐1 Drive Rapid Re‐Endothelialization of Vascular Grafts

Advanced Healthcare Materials, EarlyView.
Commercial vascular grafts are made from ePTFE, a highly hydrophobic, foreign material that fails at a high rate in small‐diameter applications. Plasma polymer nanoparticles (PPN) are a versatile material functionalisation tool, used here to present fibrillin‐1 fragment PF8 on the graft surface.
Bob S. L. Lee, Yuen Ting Lam, Alex H. P. Chan, Praveesuda L. Michael, Timothy C. Mitchell, Jui Chien Hung, Miguel Santos, Khoon S. Lim, Richard P. Tan, Steven G. Wise   +9 more
wiley   +1 more source

Illicit drug use in the Flemish nightlife scene between 2003 and 2009 [PDF]

, 2012
<i>Aims:</i> Given the importance of party people as innovators and early adaptors in the diffusion of substance use, and given the lack of longitudinal scope in studies of the nightlife scene, we explored changes in illicit drug use among ...
Bellis, Mark, Broekaert, Eric, Lammertyn, Jan, Rosiers, Johan, Van Havere, Tina, Vanderplasschen, Wouter   +5 more
core   +1 more source

Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression: A Randomized, Open-Label, Non-Inferiority Trial (KetECT)

International Journal of Neuropsychopharmacology, 2021
Background Ketamine has emerged as a fast-acting and powerful antidepressant, but no head to head trial has been performed, Here, ketamine is compared with electroconvulsive therapy (ECT), the most effective therapy for depression.
Joakim Ekstrand, Christian Fattah, Marcus Persson, Tony Cheng, P. Nordanskog, J. Åkeson, A. Tingström, Mats B Lindström, A. Nordenskjöld, Pouya Movahed Rad   +9 more
semanticscholar   +1 more source

3D‐Printed Titanium Implants with Bioactive Peptide‐Polysaccharide Scaffolds for Personalized Bone Reconstruction

Advanced Healthcare Materials, EarlyView.
Porous 3D‐printed titanium implants are made bioactive by integration with a supramolecular peptide‐hyaluronic acid nanofibrillar scaffold, without the addition of exogenous cells or growth factors. Uniform filling of the implant architecture promotes vascularized, spatially homogeneous bone regeneration, significantly enhancing osteogenesis throughout
Noam Rattner, Vladimir Perlis, Eran Golden, Ariel Pokhojaev, Rachel Sarig, Itzhak Binderman, Michal Halperin‐Sternfeld, Solomon Dadia, Lihi Adler‐Abramovich   +8 more
wiley   +1 more source

Guidelines for ketamine use in clinical psychiatry practice

BJPsych Open
In this editorial, we emphasise the efficacy and challenges of using ketamine in treatment-resistant depression. We highlight the need for comprehensive evidence-based guidelines to manage the use of both licensed and off-licence ketamine formulations ...
Luke A. Jelen, Rupert McShane, Allan H. Young   +2 more
doaj   +1 more source

Clinical research progress on the antidepressant effects of ketamine

Sichuan jingshen weisheng, 2021
Ketamine has gained increasing attention as a novel antidepressant. This article reviews the clinical studies on the antidepressant and anti-suicidal properties of ketamine and its enantiomers （R-ketamine， S-ketamine）.
Fan Ni
doaj   +1 more source