Results 11 to 20 of about 114,264 (263)

Cortical Thickness Changes in Chronic Ketamine Users

Frontiers in Psychiatry, 2021
Background: Previous studies have examined the effects of long-term ketamine use on gray matter volume. But it is unclear whether chronic ketamine use alters cortical thickness and whether cortical thickness changes in chronic ketamine users are ...
Jun Zhong, Huawang Wu, Fengchun Wu, Hongbo He, Zhaohua Zhang, Jiaxin Huang, Penghui Cao, Ni Fan   +7 more
doaj   +1 more source

The thermodynamic soliton theory of the nervous impulse and possible medical implications [PDF]

Progress in Biophysics and Molecular Biology 173 (2022) 24-35, 2022
The textbook picture of nerve activity is that of a propagating voltage pulse driven by electrical currents through ion channel proteins, which are gated by changes in voltage, temperature, pressure or by drugs. All function is directly attributed to single molecules. We show that this leaves out many important thermodynamic couplings between different
arxiv   +1 more source

Ketamine infusion as a sedative-analgesic in severe ARDS (KISS)

Journal of Community Hospital Internal Medicine Perspectives, 2021
Rationale Ketamine has been used as a sedative analgesic in trauma setting, but data regarding its efficacy and safety is lacking in severe ARDS.
Ramakanth Pata, Pagali Sandeep, Htun Min Aung, Meet J Patel, Tsering Dolkar, Nway Nway, Kosuru Bhanu, Abolfazl Ahmady, Roudabeh Kiani, Ramaiah Swaroop, Frances Schmidt, Danilo Enriquez   +11 more
doaj   +1 more source

Prenatal ketamine exposure causes abnormal development of prefrontal cortex in rat. [PDF]

, 2016
Ketamine is commonly used for anesthesia and as a recreational drug. In pregnant users, a potential neurotoxicity in offspring has been noted. Our previous work demonstrated that ketamine exposure of pregnant rats induces affective disorders and ...
Li, C, Ma, D, Song, X, Wei, W, Zhang, H, Zhao, T, Zhou, L   +6 more
core   +1 more source

Determination of Diffusion Kinetics of Ketamine in Brain Tissue: Implications for in vitro Mechanistic Studies of Drug Actions

Frontiers in Neuroscience, 2021
Ketamine has been in use for over 50 years as a general anesthetic, acting primarily through blockade of N-methyl-D-aspartate receptors in the brain. Recent studies have demonstrated that ketamine also acts as a potent and rapid-acting antidepressant ...
Zachary Geiger, Brett VanVeller, Zarin Lopez, Abdel K. Harrata, Kathryn Battani, Lauren Wegman-Points, Li-Lian Yuan   +6 more
doaj   +1 more source

Non-equilibrium brain dynamics as a signature of consciousness [PDF]

Phys. Rev. E 104, 014411 (2021), 2020
The cognitive functions of human and non-human primates rely on the dynamic interplay of distributed neural assemblies. As such, it seems unlikely that cognition can be supported by macroscopic brain dynamics at the proximity of thermodynamic equilibrium.
arxiv   +1 more source

Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice. [PDF]

, 2015
BackgroundKetamine produces schizophrenia-like behavioral phenotypes in healthy people. Prolonged ketamine effects and exacerbation of symptoms after the administration of ketamine have been observed in patients with schizophrenia.
Buell, Mahalah R, Geyer, Mark A, Higa, Kerin K, Ji, Baohu, Powell, Susan B, Risbrough, Victoria B, Young, Jared W, Zhou, Xianjin   +7 more
core   +1 more source

Subanesthetic ketamine treatment promotes abnormal interactions between neural subsystems and alters the properties of functional brain networks [PDF]

, 2014
Acute treatment with subanesthetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely utilized as a translational model for schizophrenia. However, how acute NMDA receptor blockade impacts on brain functioning at a
A Bifone, A Marsman, A Nikiforuk, A Stuchlik, A Verma, AC Lahti, AK Malhotra, AS Meyer-Lindenberg, B Moghaddam, BM Roberts, Brian J Morris, C Chih-Liang, C Corradi-Dell'Acqua, C De la Fuente-Sandoval, C Mirjana, Carsten M. Klingner, CJA Morgan, DC D’Souza, Desmond J Higham, DS Bassett, FR Sharp, FX Vollenweider, FX Vollenweider, G Paxinos, GD Honey, GE Duncan, H Metzer, J Cosgrove, J McCulloch, JA Saunders, JD Jentsch, JH Krystal, JH Krystal, JJ Kim, JM McNally, Judith A Pratt, JW Langsjo, JW Moore, K Hill, K Skoblenick, L Deserno, LJ Steward, M Amargos-Bosch, M Hauser, M Irifune, M Niesters, Martin McDonald, ME Jackson, ME Lynall, N Dawson, N Dawson, N Dawson, N Dawson, N Lindefors, N Pitsikas, ND Woodward, Neil Dawson, NR Driesen, R Galci, R Schlösser, RC Welsh, S Benetti, S Marenco, S Micheloyannis, S Miyamoto, SA Spence, SM Cochran, SP Kulikova, SY Yang, T Kos, T Kubota, Tatsunobu Natsubori, VP Bakshi, X Xiao, Y Li, Y Liu, Y Zhang, Y Zhou   +77 more
core   +1 more source

Intravenous ketamine for subacute treatment of refractory chronic migraine: a case series. [PDF]

, 2016
BACKGROUND: Refractory migraine is a challenging condition with great impact on health related quality of life. Intravenous (IV) ketamine has been previously used to treat various refractory pain conditions.
Ashina, Sait, Lauritsen, Clinton, Lipton, Richard B., Mazuera, Santiago   +3 more
core   +3 more sources

Identifying Ketamine Responses in Treatment-Resistant Depression Using a Wearable Forehead EEG [PDF]

IEEE Transactions on Biomedical Engineering (Page(s): 1668 - 1679, Volume: 66 , Issue: 6 , June 2019 ), 2018
This study explores the responses to ketamine in patients with treatment-resistant depression (TRD) using a wearable forehead electroencephalography (EEG) device. We recruited fifty-five outpatients with TRD who were randomised into three approximately equal-sized groups (A: 0.5 mg/kg ketamine; B: 0.2 mg/kg ketamine; and C: normal saline) under double ...
arxiv   +1 more source