Results 11 to 20 of about 345,134 (373)

Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses

Frontiers in Psychiatry, 2023
Ketamine-assisted psychotherapy is a promising new treatment for a variety of mental disorders of adolescence. There is currently an adolescent mental health crisis, with a high prevalence of disorders, diagnostic complexity, and many adolescents failing
Philip E. Wolfson, Philip E. Wolfson, Julane Andries, Julane Andries, Daniel Ahlers, Daniel Ahlers, Melissa Whippo, Melissa Whippo   +7 more
doaj   +1 more source

Outcomes and physiologic responses associated with ketamine administration after traumatic brain injury in the United States and Canada: a retrospective analysis [PDF]

Journal of Trauma and Injury, 2023
Purpose Ketamine has historically been contraindicated in traumatic brain injury (TBI) due to concern for raising intracranial pressure. However, it is increasingly being used in TBI due to the favorable respiratory and hemodynamic properties.
Austin J. Peters, Saad A. Khan, Seiji Koike, Susan Rowell, Martin Schreiber   +4 more
doaj   +1 more source

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.

American Journal of Psychiatry, 2021
Replicated international studies have underscored the human and societal costs associated with major depressive disorder. Despite the proven efficacy of monoamine-based antidepressants in major depression, the majority of treated individuals fail to ...
R. McIntyre, J. Rosenblat, C. Nemeroff, G. Sanacora, J. Murrough, M. Berk, E. Brietzke, S. Dodd, P. Gorwood, R. Ho, D. Iosifescu, C. L. López Jaramillo, S. Kasper, Kevin Kratiuk, J. G. Lee, Yena Lee, L. Lui, R. Mansur, G. Papakostas, Mehala Subramaniapillai, M. Thase, E. Vieta, A. Young, C. Zarate, S. Stahl   +24 more
semanticscholar   +1 more source

Efficacy of combined subanesthetic ketamine infusion and cervical sympathetic blockade as a symptomatic treatment of PTSD/TBI in a special forces patient with a 1-year follow-up: A case report

Heliyon, 2023
Co-occurrence of posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) symptoms are particularly prevalent in the special operations forces' community, along with other related conditions (e.g., endocrine dysregulation, sleep disorders ...
Eugene Lipov, Zubin Sethi, Guriqbal Nandra, Christopher Frueh   +3 more
doaj   +1 more source

Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms

Neuropsychopharmacology, 2023
Ketamine is an open channel blocker of ionotropic glutamatergic N -Methyl- D -Aspartate (NMDA) receptors. The discovery of its rapid antidepressant effects in patients with depression and treatment-resistant depression fostered novel effective treatments
J. Krystal, E. Kavalali, L. Monteggia
semanticscholar   +1 more source

Craving for Ketamine and Its Relationship With Clinical Outcome Indicators in Males With Ketamine Use Disorder

Frontiers in Psychiatry, 2021
Background: Craving is considered a hallmark of substance use disorder and is one of the criteria of substance use disorder. The Desires for Drug Questionnaire (DDQ) is a widely used questionnaire to assess craving for heroin. This study aimed to examine
Peng-Wei Wang, Peng-Wei Wang, Huang-Chi Lin, Huang-Chi Lin, Tai-Ling Liu, Tai-Ling Liu, Chih-Yao Hsu, Yu-Yi Yang, Hung-Chi Wu, Cheng-Fang Yen, Cheng-Fang Yen   +10 more
doaj   +1 more source

Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb

Nature, 2023
The discrepancy between the short half-life of ketamine and its long-lasting effects is due to ketamine being trapped in NMDA receptors, and its release depends on neural activity in the lateral habenula.
Shuangshuang Ma, Min Chen, Yihao Jiang, Xinkuan Xiang, Shiqi Wang, Zuohang Wu, Shuo Li, Yihui Cui, Junying Wang, Yanqing Zhu, Yan Zhang, Huan Ma, Shumin Duan, Haohong Li, Yan Yang, Christopher J. Lingle, Hailan Hu   +16 more
semanticscholar   +1 more source

Multidisciplinary development of guidelines for ketamine treatment for treatment-resistant major depression disorder for use by adult specialist mental health services in New Zealand

BJPsych Open, 2023
Background The evidence base for racemic ketamine treatment for treatment-resistant major depressive disorder (TRD) continues to expand, but there are major challenges translating this evidence base into routine clinical care.
Ben Beaglehole, Paul Glue, Mike Clarke, Richard Porter   +3 more
doaj   +1 more source

Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms

European psychiatry, 2022
Introduction Identifying a feasible model of chronic schizophrenia would be valuable for studying the possible underlying mechanism and to investigate emerging treatments.
D. Khalifa, L. Rashed, A. Shamseldeen, S. Stephan   +3 more
semanticscholar   +1 more source

NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine

Journal of Neuroscience, 2023
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the relevance of this pharmacology to its rapid (within hours of administration) antidepressant actions, which depend on mechanisms convergent with strengthening of excitatory ...
P. Zanos, K. A. Brown, Polymnia Georgiou, P. Yuan, C. Zarate, S. Thompson, T. Gould   +6 more
semanticscholar   +1 more source