Results 11 to 20 of about 174,609 (228)

Ketamine Dependence [PDF]

Anaesthesia and Intensive Care, 2002
Ketamine hydrochloride is a safe and rapid-acting non-opioid, lipid soluble anaesthetic with a short elimination half-life that is used for medical and veterinary purposes. It produces a state of “dissociative anaesthesia”, probably from action on N-methyl-D-aspartate (NMDA) receptors.
H R, Pal, N, Berry, R, Kumar, R, Ray
openaire   +2 more sources

Ketamine infusion as a sedative-analgesic in severe ARDS (KISS)

Journal of Community Hospital Internal Medicine Perspectives, 2021
Rationale Ketamine has been used as a sedative analgesic in trauma setting, but data regarding its efficacy and safety is lacking in severe ARDS.
Ramakanth Pata, Pagali Sandeep, Htun Min Aung, Meet J Patel, Tsering Dolkar, Nway Nway, Kosuru Bhanu, Abolfazl Ahmady, Roudabeh Kiani, Ramaiah Swaroop, Frances Schmidt, Danilo Enriquez   +11 more
doaj   +1 more source

A survey of drug liking and cravings in patients using sublingual or intranasal ketamine for treatment resistant depression: A preliminary evaluation of real world addictive potential

Frontiers in Psychiatry, 2022
Ketamine has gained rapid popularity as a treatment option for treatment resistant depression (TRD). Though seen only in limited contexts, ketamine is a potential drug of abuse, addiction and diversion.
Brittany Chubbs, Jay Wang, Shaina Archer, Carson Chrenek, Atul Khullar, Michael Wolowyk, Jennifer Swainson   +6 more
doaj   +1 more source

Activation of σ1-Receptors by R-Ketamine May Enhance the Antidepressant Effect of S-Ketamine

Biomedicines, 2023
Ketamine is a racemic mixture composed of two enantiomers, S-ketamine and R-ketamine. In preclinical studies, both enantiomers have exhibited antidepressant effects, but these effects are attributed to distinct pharmacological activities.
Hans O. Kalkman
doaj   +1 more source

Cortical Thickness Changes in Chronic Ketamine Users

Frontiers in Psychiatry, 2021
Background: Previous studies have examined the effects of long-term ketamine use on gray matter volume. But it is unclear whether chronic ketamine use alters cortical thickness and whether cortical thickness changes in chronic ketamine users are ...
Jun Zhong, Huawang Wu, Fengchun Wu, Hongbo He, Zhaohua Zhang, Jiaxin Huang, Penghui Cao, Ni Fan   +7 more
doaj   +1 more source

Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the N-methyl-D-aspartate receptor subunit NR1 in the developing rat brain

BMC Anesthesiology, 2018
Background Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory ...
Changyi Wu, Jun Wang, Xiangyang Guo, Ying Zhang   +3 more
doaj   +1 more source

Repeated Administration of Ketamine can Induce Hippocampal Neurodegeneration and Long-Term Cognitive Impairment via the ROS/HIF-1α Pathway in Developing Rats

Cellular Physiology and Biochemistry, 2014
Background: Recent animal experiments have suggested that ketamine administration during development might induce widespread neurodegeneration and long-term cognitive deficits. The underlying mechanism is not fully understood.
Jia Yan, Yan Huang, Yi Lu, Jie Chen, Hong Jiang   +4 more
doaj   +1 more source

Safety, effectiveness and tolerability of sublingual ketamine in depression and anxiety: A retrospective study of off-label, at-home use

Frontiers in Psychiatry, 2022
Intravenous and intranasal ketamine have been shown to be effective therapeutic options in patients suffering from treatment-resistant depression (TRD).
Kazi Hassan, William M. Struthers, Aditya Sankarabhotla, Patrick Davis   +3 more
doaj   +1 more source

Safety and feasibility of continuous ketamine infusion for analgosedation in medical and cardiac ICU patients who received mechanical ventilation support: A retrospective cohort study.

PLoS ONE, 2022
PurposeTo assess the effect of continuous ketamine administration in patients admitted to medical and cardiac intensive care units (ICUs) and received mechanical ventilation support.MethodsWe conducted a retrospective cohort study between March 2012 and ...
Hohyung Jung, Jihye Lee, Hyun Young Ahn, Jeong Hoon Yang, Gee Young Suh, Ryoung-Eun Ko, Chi Ryang Chung   +6 more
doaj   +1 more source

Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum

Frontiers in Cellular Neuroscience, 2019
The target for the “rapid” (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants.
Kallol Bera, Aron Kamajaya, Amol V. Shivange, Anand K. Muthusamy, Anand K. Muthusamy, Aaron L. Nichols, Aaron L. Nichols, Philip M. Borden, Stephen Grant, Janice Jeon, Elaine Lin, Ishak Bishara, Theodore M. Chin, Bruce N. Cohen, Charlene H. Kim, Elizabeth K. Unger, Lin Tian, Jonathan S. Marvin, Loren L. Looger, Henry A. Lester   +19 more
doaj   +1 more source