Results 11 to 20 of about 225,419 (363)
International Review of Psychiatry, 2021 Over the last two decades, the dissociative anaesthetic agent ketamine, an uncompetitive N-Methyl-D-Aspartate (NMDA) receptor antagonist, has emerged as a novel therapy for treatment-resistant depression (TRD), demonstrating rapid and robust ...
L. Jelen, J. Stone
semanticscholar +4 more sources
Outcomes and physiologic responses associated with ketamine administration after traumatic brain injury in the United States and Canada: a retrospective analysis [PDF]
Journal of Trauma and Injury, 2023 Purpose Ketamine has historically been contraindicated in traumatic brain injury (TBI) due to concern for raising intracranial pressure. However, it is increasingly being used in TBI due to the favorable respiratory and hemodynamic properties.
Austin J. Peters +4 more
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Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses
Frontiers in Psychiatry, 2023 Ketamine-assisted psychotherapy is a promising new treatment for a variety of mental disorders of adolescence. There is currently an adolescent mental health crisis, with a high prevalence of disorders, diagnostic complexity, and many adolescents failing
Philip E. Wolfson +7 more
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European psychiatry, 2022 Introduction Identifying a feasible model of chronic schizophrenia would be valuable for studying the possible underlying mechanism and to investigate emerging treatments.
D. Khalifa +3 more
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Frontiers in Psychiatry, 2021 Background: Craving is considered a hallmark of substance use disorder and is one of the criteria of substance use disorder. The Desires for Drug Questionnaire (DDQ) is a widely used questionnaire to assess craving for heroin. This study aimed to examine
Peng-Wei Wang +10 more
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Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb
Nature, 2023 The discrepancy between the short half-life of ketamine and its long-lasting effects is due to ketamine being trapped in NMDA receptors, and its release depends on neural activity in the lateral habenula.
Shuangshuang Ma +16 more
semanticscholar +1 more source
American Journal of Psychiatry, 2021 Replicated international studies have underscored the human and societal costs associated with major depressive disorder. Despite the proven efficacy of monoamine-based antidepressants in major depression, the majority of treated individuals fail to ...
R. McIntyre +24 more
semanticscholar +1 more source
BJPsych Open, 2023 Background The evidence base for racemic ketamine treatment for treatment-resistant major depressive disorder (TRD) continues to expand, but there are major challenges translating this evidence base into routine clinical care.
Ben Beaglehole +3 more
doaj +1 more source
NMDA Receptor Glycine Binding Site Modulators for Prevention and Treatment of Ketamine Use Disorder
Pharmaceuticals, 2023 Ketamine offers a fast-acting approach to relieving treatment-resistant depression, but its abuse potential is an issue of concern. As ketamine is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) ion channel blocker, modulation of NMDAR might be an
Yu-Chin Hsiao +3 more
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