Results 31 to 40 of about 235,967 (343)

Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the N-methyl-D-aspartate receptor subunit NR1 in the developing rat brain

BMC Anesthesiology, 2018
Background Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory ...
Changyi Wu, Jun Wang, Xiangyang Guo, Ying Zhang   +3 more
doaj   +1 more source

Cortical Thickness Changes in Chronic Ketamine Users

Frontiers in Psychiatry, 2021
Background: Previous studies have examined the effects of long-term ketamine use on gray matter volume. But it is unclear whether chronic ketamine use alters cortical thickness and whether cortical thickness changes in chronic ketamine users are ...
Jun Zhong, Huawang Wu, Fengchun Wu, Hongbo He, Zhaohua Zhang, Jiaxin Huang, Penghui Cao, Ni Fan   +7 more
doaj   +1 more source

Repeated Administration of Ketamine can Induce Hippocampal Neurodegeneration and Long-Term Cognitive Impairment via the ROS/HIF-1α Pathway in Developing Rats

Cellular Physiology and Biochemistry, 2014
Background: Recent animal experiments have suggested that ketamine administration during development might induce widespread neurodegeneration and long-term cognitive deficits. The underlying mechanism is not fully understood.
Jia Yan, Yan Huang, Yi Lu, Jie Chen, Hong Jiang   +4 more
doaj   +1 more source

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Nature, 2016
Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months, to respond to these ...
P. Zanos, R. Moaddel, Patrick J. Morris, Polymnia Georgiou, J. Fischell, G. Elmer, M. Alkondon, P. Yuan, H. Pribut, Nagendra S. Singh, K. Dossou, Yuhong Fang, Xi-Ping Huang, Cheryl L. Mayo, I. Wainer, E. Albuquerque, S. Thompson, Craig J. Thomas, C. Zarate, T. Gould   +19 more
semanticscholar   +1 more source

Safety, effectiveness and tolerability of sublingual ketamine in depression and anxiety: A retrospective study of off-label, at-home use

Frontiers in Psychiatry, 2022
Intravenous and intranasal ketamine have been shown to be effective therapeutic options in patients suffering from treatment-resistant depression (TRD).
Kazi Hassan, William M. Struthers, Aditya Sankarabhotla, Patrick Davis   +3 more
doaj   +1 more source

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

Pharmacological Reviews, 2018
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. Although best characterized for its dissociative anesthetic properties, ketamine also exerts analgesic, anti-inflammatory, and antidepressant actions ...
P. Zanos, R. Moaddel, Patrick J. Morris, L. Riggs, Jaclyn N. Highland, Polymnia Georgiou, E. Pereira, E. Albuquerque, Craig J. Thomas, C. Zarate, T. Gould   +10 more
semanticscholar   +1 more source

Efficacy of propofol versus ketamine in modified electroconvulsive therapy: A prospective randomized control trial

Journal of Acute Disease, 2022
Objective: To investigate the effects of propofol and ketamine on seizure duration, hemodynamics, and recovery of electroconvulsive therapy (ECT).
Debarshi Guha, Kiran Sheshadri, Shalendra Singh, Sonia Bhan   +3 more
doaj   +1 more source

Safety and feasibility of continuous ketamine infusion for analgosedation in medical and cardiac ICU patients who received mechanical ventilation support: A retrospective cohort study.

PLoS ONE, 2022
PurposeTo assess the effect of continuous ketamine administration in patients admitted to medical and cardiac intensive care units (ICUs) and received mechanical ventilation support.MethodsWe conducted a retrospective cohort study between March 2012 and ...
Hohyung Jung, Jihye Lee, Hyun Young Ahn, Jeong Hoon Yang, Gee Young Suh, Ryoung-Eun Ko, Chi Ryang Chung   +6 more
doaj   +1 more source

Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum

Frontiers in Cellular Neuroscience, 2019
The target for the “rapid” (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants.
Kallol Bera, Aron Kamajaya, Amol V. Shivange, Anand K. Muthusamy, Anand K. Muthusamy, Aaron L. Nichols, Aaron L. Nichols, Philip M. Borden, Stephen Grant, Janice Jeon, Elaine Lin, Ishak Bishara, Theodore M. Chin, Bruce N. Cohen, Charlene H. Kim, Elizabeth K. Unger, Lin Tian, Jonathan S. Marvin, Loren L. Looger, Henry A. Lester   +19 more
doaj   +1 more source

Considerations for physicians using ketamine for sedation of children in emergency departments [PDF]

Clinical and Experimental Emergency Medicine, 2017
Objective Ketamine use in emergency departments (EDs) for procedural sedation and analgesia is becoming increasingly common. However, few studies have examined patient factors related to adverse events associated with ketamine.
Woo Sung Kim, Ji Yeon Ku, Hanbyul Choi, Hyo Jeong Choi, Ho Jung Kim, Bora Lee   +5 more
doaj   +1 more source