Fine-tuning neural excitation/inhibition for tailored ketamine use in treatment-resistant depression [PDF]
arXiv, 2021 The glutamatergic modulator ketamine has been shown to rapidly reduce depressive symptoms in patients with treatment-resistant major depressive disorder (TRD). Although its mechanisms of action are not fully understood, changes in cortical excitation/inhibition (E/I) following ketamine administration are well documented in animal models and could ...
arxiv
Administration of Nebulized Ketamine for Managing Acute Pain in the Emergency Department: A Case Series [PDF]
, 2020 Ketamine administration in sub-dissociative doses in the emergency department (ED) results in effective pain relief in patients with acute traumatic and non-traumatic pain, chronic pain, and opioid-tolerant pain.
Butt, Mahlaqa +5 more
core
Frontiers in Psychiatry, 2022 Intravenous and intranasal ketamine have been shown to be effective therapeutic options in patients suffering from treatment-resistant depression (TRD).
Kazi Hassan +3 more
doaj +1 more source
Ketamine and psychotherapy for the treatment of psychiatric disorders: systematic review
BJPsych Open, 2023 Background Ketamine is an effective short-term treatment for a range of psychiatric disorders. A key question is whether the addition of psychotherapy to ketamine treatment improves outcomes or delays relapse.
Bess M. Kew +5 more
doaj +1 more source
Translational Psychiatry, 2021 Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD).
Margaret T. Davis +4 more
doaj +1 more source
“Walking with myself by my side” - non-medical use of Ketamine
European Psychiatry, 2022 Introduction Ketamine, synthesized in 1962 as phencyclidine derivate, is denominated a “dissociative anesthetic” because of its side-effects, such as dissociative episodes and psychotic-like symptoms, which have limited its applicability on clinical ...
R. Vaz +10 more
doaj +1 more source
A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice [PDF]
, 2013 Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents.
Burnside, Wesley M. +3 more
core +3 more sources
Immobility-reducing Effects of Ketamine during the Forced Swim Test on 5-HT1A Receptor Activity in the Medial Prefrontal Cortex in an Intractable Depression Model [PDF]
, 2020 Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear.
Kitamura, Yoshihisa +3 more
core +1 more source
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum
Frontiers in Cellular Neuroscience, 2019 The target for the “rapid” (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants.
Kallol Bera +19 more
doaj +1 more source
A review on the recent application of ketamine in management of anesthesia, pain, and health care
Journal of Family Medicine and Primary Care, 2020 Ketamine is considered as a promising drug for many clinical applications even after five decades since its discovery. Ketamine is a dissociative anesthetic agent with a variety of pharmacological effects from anesthetic induction and maintenance to ...
Abolfazl Abdollahpour +2 more
doaj +1 more source