Results 41 to 50 of about 345,134 (373)
Ketamine: NMDA receptors and beyond [PDF]
, 2016 Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi +2 more
core +2 more sources
Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4
Drug Design, Development and Therapy, 2021 Background Liver cancer ranks the top four malignant cancer type worldwide, which needs effective and safe treatment. Ferroptosis is a novel form of regulated cell death driven by iron-dependent lipid peroxidation and has been regarded as a promising ...
Guannan He +5 more
semanticscholar +1 more source
Cerebral and cardiovascular effects of analgesic doses of ketamine during a target controlled general anesthesia: a prospective randomized study [PDF]
, 2017 Introduction: Ketamine is increasingly being used in various pain settings. The purpose of this study was to assess the effect of an analgesic dose of ketamine in the bispectral index (BIS), spectral edge frequency (SEF-95), density spectral array (DSA),
Araujo, A. M. +3 more
core +1 more source
BMC Anesthesiology, 2018 Background Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory ...
Changyi Wu +3 more
doaj +1 more source
Activation of σ1-Receptors by R-Ketamine May Enhance the Antidepressant Effect of S-Ketamine
Biomedicines, 2023 Ketamine is a racemic mixture composed of two enantiomers, S-ketamine and R-ketamine. In preclinical studies, both enantiomers have exhibited antidepressant effects, but these effects are attributed to distinct pharmacological activities.
Hans O. Kalkman
doaj +1 more source
Prenatal ketamine exposure causes abnormal development of prefrontal cortex in rat. [PDF]
, 2016 Ketamine is commonly used for anesthesia and as a recreational drug. In pregnant users, a potential neurotoxicity in offspring has been noted. Our previous work demonstrated that ketamine exposure of pregnant rats induces affective disorders and ...
Li, C +6 more
core +1 more source
Cellular Physiology and Biochemistry, 2014 Background: Recent animal experiments have suggested that ketamine administration during development might induce widespread neurodegeneration and long-term cognitive deficits. The underlying mechanism is not fully understood.
Jia Yan +4 more
doaj +1 more source
Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications. [PDF]
, 2017 Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of ...
Abagyan, Ruben +3 more
core +2 more sources
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Nature, 2016 Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months, to respond to these ...
P. Zanos +19 more
semanticscholar +1 more source
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Pharmacological Reviews, 2018 Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. Although best characterized for its dissociative anesthetic properties, ketamine also exerts analgesic, anti-inflammatory, and antidepressant actions ...
P. Zanos +10 more
semanticscholar +1 more source