Results 51 to 60 of about 290,727 (340)

Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury

JHEP Reports
Background & Aims: Ketamine-associated cholestatic liver injury is reported in patients with severe burn injury, but its association with patient outcome is unclear. We investigated the relationship between ketamine exposure, cholestatic liver injury,
Christian De Tymowski, François Dépret, Emmanuel Dudoignon, Nabila Moreno, Anne-Marie Zagdanski, Kyann Hodjat, Benjamin Deniau, Alexandre Mebazaa, Matthieu Legrand, Vincent Mallet   +9 more
doaj   +1 more source

Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats

Journal of Pharmacological Sciences, 2013
We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-
Kazumi Yoshizawa, Tomohisa Mori, Tamami Ueno, Mizuki Nishiwaki, Masahiro Shibasaki, Norifumi Shimizu, Minoru Narita, Tsutomu Suzuki   +7 more
doaj   +1 more source

Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder

Translational Psychiatry, 2021
Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD).
Margaret T. Davis, Nicole DellaGiogia, Paul Maruff, Robert H. Pietrzak, Irina Esterlis   +4 more
doaj   +1 more source

Illicit drug use in the Flemish nightlife scene between 2003 and 2009 [PDF]

, 2012
<i>Aims:</i> Given the importance of party people as innovators and early adaptors in the diffusion of substance use, and given the lack of longitudinal scope in studies of the nightlife scene, we explored changes in illicit drug use among ...
Bellis, Mark, Broekaert, Eric, Lammertyn, Jan, Rosiers, Johan, Van Havere, Tina, Vanderplasschen, Wouter   +5 more
core   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Behavioral sensitization and tolerance induced by repeated treatment with ketamine enantiomers in male Wistar rats.

PLoS ONE
Ketamine has gained significant attention as a fast-acting antidepressant. However, ketamine is also associated with undesirable side effects. In our preclinical study, we explored the behavioral effects of ketamine enantiomers at subanesthetic doses ...
Kristian Elersič, Anamarija Banjac, Marko Živin, Maja Zorović   +3 more
doaj   +1 more source

Intravesical Instillation of Norketamine, a Ketamine Metabolite, and Induced Bladder Functional Changes in Rats

Toxics, 2021
This study aimed to determine the mechanism of ketamine-induced cystitis without metabolism. A total of 24 adult male Sprague-Dawley rats were separated into control, ketamine, and norketamine groups.
Chung-Hsin Yeh, Bo-He Chen, Xiao-Wen Tseng, Chun-Hou Liao, Wei-Kung Tsai, Han-Sun Chiang, Yi-No Wu   +6 more
doaj   +1 more source

Postoperative pain management in children: Guidance from the pain committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative) [PDF]

, 2018
The main remit of the European Society for Paediatric Anaesthesiology (ESPA) Pain Committee is to improve the quality of pain management in children. The ESPA Pain Management Ladder is a clinical practice advisory based upon expert consensus to help to ...
Adamek, Akin, Al-Zaben, Alm, Amminnikutty, Amoli, Anderson, Anderson, Antila, Arcioni, Association of Paediatric Anaesthetists of Great Britain and Ireland, Aubrun, Aveline, Aysenur, Bailey, Bailie, Bakan, Baley, Becke, Beers, Bell, Ben-Meir, Bertini, Bhalla, Birmingham, Bouwmeester, Bozkurt, Breitfeld, Breschan, Breschan, Brown, Brown, Büttner, Carstensen, Cha, Chan, Chou, Conti, Cousins, Crellin, Cyna, Dadure, Dadure, Dahi-Taleghani, Dahmani, Dalens, Das, Derry, Derry, Duedahl, Ecoffey, El-Fattah, Elshammaa, Fendrich, Fieler, Finkel, Flack, Fösel, Ganidagli, Gear, Gemma, Ginsberg, Glover, Habre, He, Hicks, Hinz, Holmer Pettersson, Hong, Howard, Hudcova, Huenseler, Huynh, Höhne, Ingelmo, Ivani, Ivani, Ivani, Ivani, Jahr, Jaksch, José María, Ju, Jöhr, Kamata, Kart, Kimiaei Asadi, Kokki, Kokki, Kokki, Kokki, Koppert, Kost-Byerly, Kost-Byerly, Kubica-Cielińska, Kumar, Kurihara, Kwak, Lam, Laskowski, Lavonas, Leclair, Lee, Leksowski, Leoni, Litalien, Liu, Liu, Lorenzo, Lundeberg, Lönnqvist, Lönnqvist, Lönnqvist, Manworren, Marel, Marhofer, Mazoit, McNicol, Merry, Messerer, Messerer, Miller, Miró, Mobley, Mohammed, Momeni, Moriceau, Morton, Morton, Mukherjee, Müller, Mędrzycka-Dąbrowska, O'Sullivan, Olkkola, Orange, Ousley, Pace, Park, Park, Pasero, Petrat, Pierce, Polaner, Qian, Rabbitts, Redmann, Richer, Rugyte, Sahin, Sammartino, Sandeman, Schnabel, Schnabel, Schug, Schug, Schug, Schultz-Machata, Sekhavat, She, Shirazi, Sng, Soh, Sola, Soulard, Southworth, Sowder, Spacek, Splinter, Stamer, Staschen, Steans, Steffen, Subramanyam, Suresh, Taheri, Tobias, Tsuchiya, Valizadeh, Voepel-Lewis, Walker, Walther-Larsen, Walther-Larsen, Wang, Weintraud, Willschke, Willschke, Willschke, Wilson, Wilson-Smith, Wininger, Wong, Wong, Xue, Xue, Yaster, Yildiz, Yung   +196 more
core   +1 more source

Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration

Advanced Functional Materials, EarlyView.
Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong, Ji‐Young Yoon, Junyong Ahn, Byunghak Lee, Sung‐Min Park, Jae‐Heon Kim, Buuvee Bayarkhangai, Yu Jin Kim, Sak Lee, Jonathan C. Knowles, Moon‐Young Kim, DongJun Lee, Sang‐Hoon Rhee, Hae‐Hyoung Lee, Hae‐Won Kim, Jung‐Hwan Lee   +15 more
wiley   +1 more source

Effects of Perinatal Exposure to Ketamine on the Developing Brain

Frontiers in Neuroscience, 2019
Initially used as an analgesic and anesthetic, ketamine has unfortunately been abused as a popular recreational party drug due to its psychotropic effects. Over the last decade, ketamine has also emerged as an effective rapid-onset anti-depressant.
Hoi Man Cheung, Hoi Man Cheung, David Tai Wai Yew, David Tai Wai Yew   +3 more
doaj   +1 more source