Results 51 to 60 of about 235,967 (343)

Brain damages in ketamine addicts as revealed by magnetic resonance imaging

Frontiers in Neuroanatomy, 2013
Ketamine, a known antagonist of N-methyl-D-aspartic (NMDA) glutamate receptors, had been used as an anesthetic particularly for pediatric or for cardiac patients. Unfortunately, ketamine has become an abusive drug in many parts of the world while chronic
Chunmei eWang, Dong eZheng, Jie eXu, Waiping eLam, D.T. eYew   +4 more
doaj   +1 more source

Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder

Translational Psychiatry, 2021
Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD).
Margaret T. Davis, Nicole DellaGiogia, Paul Maruff, Robert H. Pietrzak, Irina Esterlis   +4 more
doaj   +1 more source

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial.

American Journal of Psychiatry, 2019
OBJECTIVE Subanesthetic ketamine doses have been shown to have rapid yet transient antidepressant effects in patients with treatment-resistant depression, which may be prolonged by repeated administration.
J. Phillips, S. Norris, J. Talbot, Meagan Birmingham, T. Hatchard, A. Ortiz, O. Owoeye, L. Batten, P. Blier   +8 more
semanticscholar   +1 more source

Illuminating New Frontiers: Exploring the Photosensitizing Potential of Passiflora Species in Combating Methicillin‐Resistant Staphylococcus aureus (MRSA) and Their Infection in Senescent Mice

Advanced Biology, EarlyView.
This study investigates the photosensitizing potential of Passiflora cincinnata in Antimicrobial Photodynamic Therapy (aPDT) against skin infection caused by Methicillin‐resistant Staphylococcus aureus (MRSA) in a senescent murine model. The P. cincinnata exhibits antimicrobial activity, with reduced bacterial load, lower leukocyte infiltration, and ...
Caroline Vieira Gonçalves, Maria Poliana Leite Galantini, Igor Pereira Ribeiro Muniz, Paulo Henrique Bispo Lima, Israel Souza Ribeiro, Maria Eduarda Santos de Oliveira, Caio Oliveira Lopes de Magalhães, Maria Elisa Santos Flores, Samara Lopes de Oliveira, Catarina Silva Guimarães, Paulinne Moreira Lima, Luísa Carregosa Santos, Daiana Silva Lopes, Juliano Geraldo Amaral, Robson Amaro Augusto da Silva   +14 more
wiley   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats

Journal of Pharmacological Sciences, 2013
We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-
Kazumi Yoshizawa, Tomohisa Mori, Tamami Ueno, Mizuki Nishiwaki, Masahiro Shibasaki, Norifumi Shimizu, Minoru Narita, Tsutomu Suzuki   +7 more
doaj   +1 more source

Intravesical Instillation of Norketamine, a Ketamine Metabolite, and Induced Bladder Functional Changes in Rats

Toxics, 2021
This study aimed to determine the mechanism of ketamine-induced cystitis without metabolism. A total of 24 adult male Sprague-Dawley rats were separated into control, ketamine, and norketamine groups.
Chung-Hsin Yeh, Bo-He Chen, Xiao-Wen Tseng, Chun-Hou Liao, Wei-Kung Tsai, Han-Sun Chiang, Yi-No Wu   +6 more
doaj   +1 more source

Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective

Psychiatry and Clinical Neurosciences, 2019
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders. Approximately one‐third of the patients with MDD are treatment resistant to the current antidepressants.
K. Hashimoto
semanticscholar   +1 more source

Fabrication of Free‐Standing Undulating Graphene Oxide Modular Tapered Pipes Using the Marangoni Effect

Advanced Functional Materials, EarlyView.
Free‐standing undulating graphene oxide (GO) modular tapered pipes fabricated based on the Marangoni effect and viscosity control are modular tubular structures that effectively utilize the lamination process between GO films. This novel tubular GO structure allows for the realization of various forms through the assembly of identical modules ...
Cheol‐Hwi Kim, Jeong Hyun Heo, Fu Nan Ju, Seo Young Kim, Chang‐Dae Kim, Hyungbin Son, Zhengtang Luo, Yoonhee Jin, Tae‐Hyung Kim   +8 more
wiley   +1 more source

Behavioral sensitization and tolerance induced by repeated treatment with ketamine enantiomers in male Wistar rats.

PLoS ONE
Ketamine has gained significant attention as a fast-acting antidepressant. However, ketamine is also associated with undesirable side effects. In our preclinical study, we explored the behavioral effects of ketamine enantiomers at subanesthetic doses ...
Kristian Elersič, Anamarija Banjac, Marko Živin, Maja Zorović   +3 more
doaj   +1 more source