Results 81 to 90 of about 57,314 (316)

Enhancement of ketoconazole dissolution rate by the liquisolid technique

Acta Pharmaceutica, 2018
The study was conducted to enhance the dissolution rate of ketoconazole (KCZ) (a poorly water-soluble drug) using the liquisolid technique. Microcrystalline cellulose, colloidal silica, PEG400 and polyvinyl pyrrolidone (PVP) were employed as a carrier ...
Molaei Mir-Ali, Osouli-Bostanabad Karim, Adibkia Khosro, Shokri Javad, Asnaashari Solmaz, Javadzadeh Yousef   +5 more
doaj   +1 more source

Ketoconazole Foam ??? Connetics

Drugs in R & D, 2003
Connetics Corporation (USA) is developing a foam formulation of 2% ketoconazole [Extina] for the treatment of mycoses and dermatological indications, particularly seborrhoeic dermatitis. The product utilises Connetics' proprietary foam drug delivery technology, VersaFoam, and is currently awaiting registration in the US for the treatment of seborrhoeic
openaire   +2 more sources

Hairy Tongue [PDF]

, 2017
Hairy tongue (lingua villosa) is a commonly observed condition of defective desquamation of the filiform papillae that results from a variety of precipitating factors. [1] The condition is most frequently referred to as black hairy tongue (lingua villosa
Burgess, Jeff, Butler, David F., Eisen, Drore, Handler, Marc Zachary, Lynch, Denis P, Stafford, Gary L   +5 more
core   +1 more source

Isavuconazole and Calcium Channel Blocker for Invasive Fungal Disease Accompanied With Hypertension: Evidence From the FAERS and PBPK/PD Model

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
Safety assessment of ISA in combination with CCBs. Disproportionality analysis through the FAERS database showed that ISA was not associated with drug‐induced hypertension and DDI‐caused hypotension, whereas CCBs (nifedipine and amlodipine) were the most common co‐medications for hypotension occurring in combination with TADs.
Jianxing Zhou, Bo Xiao, Zipeng Wei, Mengting Jia, Xin Luo, Huimin Wei, Xiaohan Zhang, Maobai Liu, Yifan Zhang, Xuemei Wu   +9 more
wiley   +1 more source

Utilization of alginate with gum acacia/pectin/carrageenan as precipitation inhibitor to improve bioavailability in drug supersaturation: A case study of ketoconazole

Carbohydrate Polymer Technologies and Applications, 2023
Weak base drugs tend to precipitate in the intestine, leading to a decrease in their bioavailability. Precipitation initiates with supersaturation due to a pH shift from the stomach to the small intestine.
Viviane Annisa, Teuku Nanda Saifullah Sulaiman, Akhmad Kharis Nugroho, Agung Endro Nugroho   +3 more
doaj  

Hydrogel of Ketoconazole and PAMAM Dendrimers: Formulation and Antifungal Activity

Molecules, 2012
Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages.
Elzbieta Tryniszewska, Pawel Tomasz Sacha, Piotr Wieczorek, Magdalena Wroblewska, Katarzyna Winnicka   +4 more
doaj   +1 more source

Pharmacokinetics of the cyclosporine-ketoconazole interaction in dogs [PDF]

, 1989
Numerous clinical reports have documented an increase in trough blood concentrations of cyclosporine in transplant recipients treated concomitantly with ketoconazole.
Burckart, GJ, D'mello, A, Ptachcinski, RJ, Satake, M, Starzl, TE, Takaya, S, Todo, S, Venkataramanan, R   +7 more
core  

Parathyroid localization [PDF]

, 1986
Twenty-nine consecutive patients with suspected primary hyperparathyroidism were examined preoperatively using ultrasound, sonographically guided fine needle aspiration, and aspirate immunostaining for PTH.
Borisch, B., Gutekunst, R., Hafermann, W., Kiffner, E., Löhrs, U., Scriba, Peter Christian, Thies, E., Valesky, A.   +7 more
core   +1 more source

Impact of Mechanistic Modeling and Simulation Methodologies on Product‐Specific Guidance Development for Non‐Orally Administered Drug Products

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The U.S. Food and Drug Administration (FDA) publishes product‐specific guidances (PSGs), with bioequivalence (BE) recommendations for prospective generics. Developing BE recommendations for non‐orally administered drug products including long‐acting injectables (LAI), orally inhaled drug products, and drugs applied locally to the skin ...
Steven G. Chopski, Ross L. Walenga, Ming‐Liang Tan, Khondoker Alam, Andrew Babiskin, Lanyan Fang, Eleftheria Tsakalozou   +6 more
wiley   +1 more source

TREATMENT OF CUTANEOUS LEISHMANIASIS WITH KETOCONAZOLE CREAM

Journal of Research in Medical Sciences, 2001
n Iran. Many drugs have been suggested for treatment of CL but non of them proved to be effective. Recently ketoconazole has been used to treat CL patients and it has been reported that was effective.
A MOMENI, M AMINJAVAHERI, M.R OMIDGHAEMI
doaj