Combination treatment of epilepsy with ketogenic diet and concurrent pharmacological inhibition of cytochrome P450 2E1 [PDF]
, 2013 The final publication is available at Elsevier via http://dx.doi.org/10.1016/j.mehy.2013.01.011 © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/While most epileptic ...
Palmer, Michael
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Ketogenic therapy for schizophrenia: evidence, mechanisms, and clinical perspectives
Frontiers in PharmacologyIntroductionSchizophrenia is a chronic psychiatric disorder marked by significant cognitive and functional impairments. Current antipsychotic treatments offer limited benefit for negative symptoms and cognitive dysfunction while often exacerbating ...
Cristiano Chaves +12 more
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In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma. [PDF]
, 2019 Dysregulation in NAD+/NADH levels is associated with increased cell division and elevated levels of reactive oxygen species in rapidly proliferating cancer cells.
Batsios, Georgios +7 more
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Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report [PDF]
Nutrition & Metabolism, 2010 Management of glioblastoma multiforme (GBM) has been difficult using standard therapy (radiation with temozolomide chemotherapy). The ketogenic diet is used commonly to treat refractory epilepsy in children and, when administered in restricted amounts, can also target energy metabolism in brain tumors.
Servadei Franco +6 more
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Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis [PDF]
, 2018 Background: Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases.
Bock, Markus +2 more
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Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy. [PDF]
PLoS ONE, 2015 The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously showed that two non-toxic metabolic therapies - the ketogenic diet with concurrent hyperbaric ...
A M Poff +4 more
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Role of choline deficiency in the fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet [PDF]
, 2013 Though widely employed for clinical intervention in obesity, metabolic syndrome, seizure disorders and other neurodegenerative diseases, the mechanisms through which low carbohydrate ketogenic diets exert their ameliorative effects still remain to be ...
Brunt, Elizabeth M +4 more
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Lennox-Gastaut Syndrome: A State of the Art Review. [PDF]
, 2017 Lennox-Gastaut syndrome (LGS) is a severe age-dependent epileptic encephalopathy usually with onset between 1 and 8 years of age. Functional neuroimaging studies recently introduced the concept of Lennox-Gastaut as "secondary network epilepsy" resulting ...
Mastrangelo, Mario
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The role of β-hydroxybutyrate testing in ketogenic metabolic therapies
Frontiers in NutritionAccurate assessment of dietary adherence and metabolic outcomes remains a critical challenge in most nutrition studies. Ketogenic metabolic therapies (KMTs) provide a unique advantage by inducing nutritional ketosis and enabling the use of ketone bodies as biomarkers of metabolic state.
Fante, Cristina +5 more
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Practical guidelines for addressing common questions and misconceptions about the ketogenic diet
Journal of Metabolic HealthResearch publications on the ketogenic diet have experienced an exponential increase in recent years, driving clinical interest, which has expanded along with media interest.
Sarah M. Rice, Douglas B. Reynolds
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