Results 81 to 90 of about 9,981 (208)

Intensive Multimodal Ketogenic Metabolic Therapy in Glioblastoma: A Clinical Trial

Neuro-Oncology Advances
Abstract Background Glioblastoma (GBM), isocitrate dehydrogenase (IDH)-wildtype, has a median overall survival of 11–14 months despite standard treatment. Ketogenic metabolic interventions that lower the glucose ketone index (GKI) may improve outcomes. We evaluated the feasibility, tolerability,
Matthew C L Phillips, Ziad Thotathil, Nur Azri Bin Haji Mohd Yasin, Charles De Groot, Alvin Tan, Marion Kuper-Hommel, Lee-Ann Creagh, Eric Ji, Nichola Naidoo, Mariska Van Essen, Fouzia Ziad, Ben G Moon, Chris Frampton, Michael B Jameson   +13 more
openaire   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The Effect of a Ketogenic Diet on Cancer: Evidence From Systematic Reviews and Meta-Analyzes

Integrative Cancer Therapies
Background: Emerging evidence suggests that the ketogenic diet (KD) may support cancer treatment by improving metabolic parameters and reducing treatment-related side effects.
Majid Kamali Msc, Masoomeh Ataei Kachooei MD, Bahareh Aminnezhad MSc, Elham Nikoei Foshtomi MSc, Alireza Eftekhar MSc, Ali Shamsi-Goushki PhD, Saeideh Mohammadi MSc, Ali Nouri MSc, Mohammad Esmail Akbari MD, Mona Zendehdel MSc, Bita Moradi BSc, Narjes Ashouri Mirsadeghi MSc, Parsa Bahmani BSc, Farnush Bakhshimoghaddam PhD, Razieh Bahiraie BSc, Hamid Abbasi BSc, Saeid Doaei PhD, Maryam Gholamalizadeh PhD   +17 more
doaj   +1 more source

Management of Infantile Epileptic Spasms Syndrome: A survey of US pediatric hospitals

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the management practices of Infantile Epileptic Spasms Syndrome (IESS) across tertiary pediatric hospitals in the United States using a survey‐based approach. Methods A 21‐question survey focused on management setting, work‐up, follow‐up and treatment was created and sent to 45 member institutions of the Pediatric ...
Akshat Katyayan, Christina Briscoe, Sonam Bhalla, Sonal Bhatia, Gozde Erdemir, Chellamani Harini, Senyene E. Hunter, John R. Mytinger, Duyu Nie, Archana Pasupuleti, Shital H. Patel, Debopam Samanta, Amanda Sandoval Karamian, Avantika Singh, Deepa Sirsi, Danielle S. Takacs, Shaun A. Hussain   +16 more
wiley   +1 more source

From glucose to histone modification: sex-specific metabolic responses to ketogenic therapy in VM/Dk mice

Frontiers in Nutrition
IntroductionThe assessment of sex-specific effects in pre-clinical models is critical for improving the translatability of findings to clinical applications.
Sara E. Moss, Angela M. Poff, Apryl Moss, Janine M. DeBlasi, Dominic P. D’Agostino   +4 more
doaj   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Phenotype‐guided etiologic workup in a prospective cohort of 144 adults with developmental and epileptic encephalopathy

Epilepsia Open, EarlyView.
Abstract Objectives Adults with developmental and epileptic encephalopathies (DEEs) often enter adult neurology care without etiologic clarification because of incomplete transition from pediatric services, outdated investigations, and attenuation of childhood electro‐clinical features over time.
Giuseppe d’Orsi, Umberto Costantino, Maria Teresa Di Claudio, Carmela Pia Ferro, Pietro Palumbo, Mario Benvenuto, Massimiliano Copetti, Leonardo D'Agruma, Massimo Carella, Marco Castori, Orazio Palumbo   +10 more
wiley   +1 more source

Low-Carbohydrate (Ketogenic) Diet in Children with Obesity: Part 1—Diet Impact on Anthropometric Indicators and Indicators of Metabolic Syndrome and Insulin Resistance

Diseases
Background: The ketogenic diet has been successfully used in the last 100 years in the treatment of epilepsy and other neurological disorders. In recent decades, it gained wider application in the treatment of obesity, metabolic syndrome, and type 2 ...
Ivanka N. Paskaleva, Nartsis N. Kaleva, Teodora D. Dimcheva, Petya P. Markova, Ivan S. Ivanov   +4 more
doaj   +1 more source

Craniotomy Complicated by Severe Metabolic Acidosis Requiring Massive Transfusion in an Infant on Ketogenic Diet Therapy for Intractable Epilepsy

International Medical Case Reports Journal, 2022
Seth B Hayes,1,2 Dolly M Munlemvo,1 Holly C Gillis,1,2 Joseph D Tobias1,2 1Department of Anesthesiology & Pain Medicine, Nationwide Children’s Hospital, Columbus, OH, USA; 2Department of Anesthesiology & Pain Medicine, The Ohio State University College ...
Hayes SB, Munlemvo DM, Gillis HC, Tobias JD   +3 more
doaj  

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source