Results 101 to 110 of about 10,739 (204)

Efficacy and Safety of CagriSema in Type 2 Diabetes: A Dose‐ and Comparator‐Specific Systematic Review and Bayesian Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background CagriSema combines cagrilintide with semaglutide and may improve glycaemic control and body weight in Type 2 diabetes. We evaluated its dose‐ and comparator‐specific efficacy and safety. Methods PubMed, Embase, CENTRAL and ClinicalTrials.gov were searched through 30 June 2026 for randomized controlled trials.
Chia Siang Kow, Abdullah Faiz Zaihan, Dinesh Sangarran Ramachandram, Kaeshaelya Thiruchelvam   +3 more
wiley   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Local and Systemic Risk Factors of Dental Biofilm‐Induced Gingivitis and Their Control: A Systematic Review

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Objectives To identify local and systemic risk factors/indicators for dental biofilm‐induced gingivitis (DB‐GI) and to summarize evidence for their control. Methods A systematic review was undertaken following Preferred Reporting Items for Systematic Review and Meta‐Analyses (PRISMA) guidelines and divided into PECOTS and PICOTS questions ...
M. Gosset, E. Chatzopoulou, L. Detzen, K. Jepsen, P.‐M. Jervøe‐Storm, S. Jepsen, R. Cosgarea   +6 more
wiley   +1 more source

Type 1 diabetes in the era of obesity: Pathophysiology and therapeutic implications

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Type 1 diabetes is defined by immune‐mediated beta‐cell failure and dependence on exogenous insulin. That definition is correct, but it may not fully describe many people seen in current clinical practice. Overweight and obesity are now common in type 1 diabetes, leading to variable combinations of high insulin requirement, hypertension ...
Zachary Bloomgarden
wiley   +1 more source

Pathogenesis of hidradenitis suppurativa: From susceptibility to chronicity

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review describes hidradenitis suppurativa as a heterogeneous disorder in which genetic susceptibility, epithelial dysfunction, environmental exposures, immune activation and microbial ecology converge differently across patients and disease stages.
Kelsey R. van Straalen, Nisha S. Chandran, Jean M. Fletcher, Evangelos J. Giamarellos‐Bourboulis, Elia Rosi, Gregor B. E. Jemec   +5 more
wiley   +1 more source

Mindful and Intuitive Eating: A Bibliometric Analysis of Research Trends From 2004 to 2024

Obesity Reviews, EarlyView.
ABSTRACT Introduction Excessive body weight and problematic eating behaviors are major public health concerns. Mindful eating and intuitive eating offer alternative approaches to dieting by encouraging individuals to focus on internal hunger and satiety cues.
Mengying Zhang, Angeliki Bogossian, Emma Stanmore, Trudi Edginton, Siobhán O′Connor   +4 more
wiley   +1 more source

From ketogenic metabolism to targeted therapeutics: current advances in β-hydroxybutyrylation

Frontiers in Immunology
β-Hydroxybutyrylation (Kbhb) is a novel posttranslational modification (PTM) mediated by β-hydroxybutyrate (BHB). BHB, the core product of ketogenic metabolism, serves as its direct precursor and substrate.
Fangshuai Hu, Fangshuai Hu, Changming Liang, Changming Liang, Xu Zhang, Xu Zhang, Lishuai Xu, Lishuai Xu, Chengwei Wu, Chengwei Wu, Senlin Wan, Senlin Wan, Jiawei Wang, Jiawei Wang, Mengyun Wang, Mengyun Wang, Dawei Zhang, Dawei Zhang, Yongchun Liu, Yongchun Liu, Zhenyuan Li, Zhenyuan Li, Xiaoming Wang, Xiaoming Wang, Xiaoxu Huang, Li Xu, Li Xu, Li Xu   +27 more
doaj   +1 more source

Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)

Obesity Reviews, EarlyView.
Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo, Tamayo Mateo, Henao Diana, Juan P. Polanco, Cortés David, Juan C. Alba, Giha Valeria, Camargo Camilo, Hernández Eder, Correa Ricardo, Nassar Ricardo, Cabandugama Peminda, Marcio L. Griebeler, Burguera Bartolome   +13 more
wiley   +1 more source

Toward “Obesityomics”: Domain‐Specific Omics in Precision Obesity Medicine with a Brief AI Perspective

Obesity Reviews, EarlyView.
ABSTRACT Background Obesity's global rise has outpaced the effectiveness of “one‐size‐fits‐all” prevention and treatment strategies. The promise of precision medicine lies in addressing the etiological and biological diversity of obesity and transforming it into actionable endotypes.
Nadia Abu Samra, Sara G. I. Suliman, Mohammed Al‐Hadad, Dorret I. Boomsma, Fadwa Alhantoobi, Maithah Alsamahi, Haneen Abufarajallah, Alia Al Tikriti, Zeyar Aung, Selena Richards, Abdulrahim Sajini, Mira Mousa, Fatima Sulaiman, Wael Osman   +13 more
wiley   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source