Results 111 to 120 of about 10,739 (204)

Administration of ketogenic intervention as a potential treatment during post-traumatic brain injury recovery: a scoping review

Frontiers in Nutrition
BackgroundTraumatic brain injury (TBI) affects 69 million individuals annually and represents a major global health burden. Ketogenic interventions have emerged as a potential therapy to address deficits following TBI.
Daaniyal Y. Quddus, Serhat Aydin, Ayesha Akbar Waheed, Qazi Zeeshan, Qazi Zeeshan, D. Kojo Hamilton, D. Kojo Hamilton, D. Kojo Hamilton, Nitin Agarwal, Joseph C. Maroon   +9 more
doaj   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Dietary amino acid patterns and epilepsy among the PERSIAN cohort population: A cross‐sectional study

Experimental Physiology, EarlyView.
Abstract Epilepsy is characterized by the occurrence of at least two unprovoked seizures occurring more than 24 h apart, reflecting a predisposition to recurrent epileptic events. The role of dietary amino acids (AAs) in epilepsy is not clearly understood. To the best of our knowledge, this study is the first to investigate the link between the odds of
Hamid Abbasi, Ali Jafari, Saeid Doaei, Akram Kooshki, Raul Zamora‐Ros   +4 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Pablo Ranea‐Robles   +3 more
wiley   +1 more source

Metabolism of fatty acids and ketone bodies for glioblastoma growth: Implications for Ketogenic Diet Therapy

, 2019
ABSTRACT Glioblastoma (GBM) metabolism has traditionally been characterized by a dependence on aerobic glycolysis, prompting use of the ketogenic diet as a potential therapy. We observed growth-promoting effects on U87 GBM of both ketone body and fatty acid (FA) supplementation under physiological glucose conditions.
Sperry, Jantzen, Le Belle, Janel E., Condro, Michael C., Guo, Lea, Braas, Daniel, Vanderveer-Harris, Nathan, Kim, Kristen K.O., Pope, Whitney B., Divakaruni, Ajit S., Lai, Albert, Christofk, Heather, Kornblum, Harley I.   +11 more
openaire   +2 more sources

Renin–Angiotensin System Activation Drives Early Cardiorenal Dysfunction in Normotensive Prediabetes

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Increased angiotensin‐converting enzyme 1 (ACE1) expression in perivascular and perirenal adipose tissues of prediabetic rats contributes to early cardiovascular and cardiorenal deterioration in the absence of obesity and hypertension. Systemic Angiotensin II exacerbates the observed detrimental effects of prediabetes.
Nour‐Mounira Z. Bakkar, Rana Ghazi, Nahed Mougharbil, Safaa H. Hammoud, Ramzi Sabra, Ali H. Eid, Ahmed F. El‐Yazbi   +6 more
wiley   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

Additional file 5 of Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Supplementary Material 5.
Duraj, Tomás, Kalamian, Miriam, Zuccoli, Giulio, Maroon, Joseph C., D’Agostino, Dominic P., Scheck, Adrienne C., Poff, Angela, Winter, Sebastian F., Hu, Jethro, Klement, Rainer J., Hickson, Alicia, Lee, Derek C., Cooper, Isabella, Kofler, Barbara, Schwartz, Kenneth A., Phillips, Matthew C. L., Champ, Colin E., Zupec-Kania, Beth, Tan-Shalaby, Jocelyn, Serfaty, Fabiano M., Omene, Egiroh, Arismendi-Morillo, Gabriel, Kiebish, Michael, Cheng, Richard, El-Sakka, Ahmed M., Pflueger, Axel, Mathews, Edward H., Worden, Donese, Shi, Hanping, Cincione, Raffaele Ivan, Spinosa, Jean Pierre, Slocum, Abdul Kadir, Iyikesici, Mehmet Salih, Yanagisawa, Atsuo, Pilkington, Geoffrey J., Chaffee, Anthony, Abdel-Hadi, Wafaa, Elsamman, Amr K., Klein, Pavel, Hagihara, Keisuke, Clemens, Zsófia, Yu, George W., Evangeliou, Athanasios E., Nathan, Janak K., Smith, Kris, Fortin, David, Dietrich, Jorg, Mukherjee, Purna, Seyfried, Thomas N.   +48 more
openaire   +1 more source

Tailored Amino Acid Treatment for Pediatric Patients With Mitochondrial Aminoacyl‐tRNA Synthetase Deficiencies

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Aminoacyl‐tRNA synthetases (ARSs) facilitate the loading of transfer RNAs with their cognate amino acids in the cytosol (ARS1), mitochondria (ARS2), or both (dual ARS). ARS deficiencies are clinically heterogeneous and can cause severe, occasionally fatal disease.
I. J. J. Muffels, G. Kok, Z. Tang, L. S. Medeiros, F. O. Poswar, W. P. Vermeij, R. Rodenburg, K. Smit, S. K. Sukumaran, S. B. Wortmann, L. Averdunk, J. Munch, J. Pak‐lam Ho, A. M. K. Kwok, E. E. S. Nieuwenhuis, P. M. van Hasselt, I. V. D. Schwartz, C. M. A. Lubout, A. M. Bosch, K. Koop, E. M. M. Hoytema van Konijnenburg, S. A. Fuchs   +21 more
wiley   +1 more source