Results 71 to 80 of about 10,739 (204)

The Hypometabolic State of the Migraine Brain: Is a Ketogenic Diet the Answer?

Brain and Behavior
Background Migraine pathophysiology involves a constellation of metabolic abnormalities. These interlinked contributory factors include mitochondrial dysfunction, an altered gut microbiome, neuroinflammation, oxidative stress, weight imbalance, and ...
Lakshini Gunasekera, Jason C. Ray, Helmut Butzkueven, Terence J. O'Brien, Elspeth Hutton, Neha Kaul   +5 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Practical guidelines for addressing common questions and misconceptions about the ketogenic diet

Journal of Metabolic Health
Research publications on the ketogenic diet have experienced an exponential increase in recent years, driving clinical interest, which has expanded along with media interest.
Sarah M. Rice, Douglas B. Reynolds
doaj   +1 more source

Long-Term Ketogenic Diet Induces Metabolic Acidosis, Anemia, and Oxidative Stress in Healthy Wistar Rats

Journal of Nutrition and Metabolism, 2020
Background. Ketogenic diet has been used as supportive therapy in a range of conditions including epilepsy, diabetes mellitus, and cancer. Objective.
Aryadi Arsyad, Irfan Idris, Andi A. Rasyid, Rezky A. Usman, Kiki R. Faradillah, Wa Ode U. Latif, Zidni I. Lubis, Aminuddin Aminuddin, Ika Yustisia, Yulia Y. Djabir   +9 more
doaj   +1 more source

Managing Metastatic Thymoma With Metabolic and Medical Therapy: A Case Report

Frontiers in Oncology, 2020
Thymomas consist of neoplastic thymic cells intermixed with variable numbers of non-neoplastic lymphocytes. Metastatic thymomas are typically managed with non-curative chemotherapy to control tumor-related symptoms; no prolonged survival is expected ...
Matthew C. L. Phillips, Deborah K. J. Murtagh, Sanjay K. Sinha, Ben G. Moon   +3 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model.

PLoS ONE, 2015
IntroductionNeuroblastoma is a malignant pediatric cancer derived from neural crest cells. It is characterized by a generalized reduction of mitochondrial oxidative phosphorylation.
Raphael Johannes Morscher, Sepideh Aminzadeh-Gohari, René Gunther Feichtinger, Johannes Adalbert Mayr, Roland Lang, Daniel Neureiter, Wolfgang Sperl, Barbara Kofler   +7 more
doaj   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Ketogenic diet treatment in adults with glycogenosis type IIIa (Morbus Cori)

Clinical Nutrition Experimental, 2019
Summary: Background: Glycogen storage disease type IIIa (GSDIIIa) is a defect of the debranching enzyme (amylo-1,6-glucosidase) in glycogenolysis and has an effect on the muscles and the liver.
Tobias Fischer, Helen Njoroge, Ulrike Och, Ira Klawon, Thorsten Marquardt   +4 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source