Results 221 to 230 of about 167,615 (302)

Dyotropic Rearrangement of Hypervalent Iodine Species: Migrative Heterofunctionalization of Quaternary Carbons

Angewandte Chemie, EarlyView.
1,2‐Aryl migration involving in situ‐generated alkyl iodine(III) species proceeds through a previously unrecognized 1,2‐C/I(III) dyotropic rearrangement. Migratory aryl fluorination, acetoxylation, and alkoxylation of 2‐alkyl‐2‐aryl‐3‐iodopropanoates provide α‐heterofunctionalized products, accompanied by aryl migration from the α‐ to the β‐position ...
Chen‐Xu Liu, Qian Wang, Matthew D. Wodrich, Jieping Zhu   +3 more
wiley   +1 more source

Ketone bodies in kidney diseases: novel insights. [PDF]

Front Immunol
Dai W, Zhang W, Li H, Gao Y, Xiao L, Chen Y, He L.   +6 more
europepmc   +1 more source

1,4‐Brook Rearrangement of β‐Silyl Allylic Alcohols: Trisubstituted Alkenes by Copper‐Mediated Stereoretentive ipso‐Substitution Reactions

Angewandte Chemie, EarlyView.
To fully leverage the power of the ruthenium‐catalyzed trans‐hydrosilylation of propargyl alcohols, it was necessary to develop a practical and robust method for the activation of those products that carry the silyl group distal to the hydroxy substituent.
Paul Haf‐Moths, Jack L. Sutro, Alois Fürstner   +2 more
wiley   +1 more source

Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus. [PDF]

Diabetes
Tricò D, Jiang L, Spicer D, Page K, Belfort de Aguiar R, Naik S, Savoye M, Caseria DM, Arora J, Mason GF, Constable T, Rothman DL, Herzog RI.   +12 more
europepmc   +1 more source

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, EarlyView.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +1 more source

Effects of ketone bodies supplementation in patients with heart failure: A systematic review and meta-analysis. [PDF]

World J Crit Care Med
Siddiqi AK, Javaid SS, Kumar A, Kumar N, Ahmad M, Akhtar S, Raja AR, Ladhani D, Kumari N, Kumar S.   +9 more
europepmc   +1 more source

Entdeckung der cyclischen Form des MRT‐pH‐Sensors Z‐OMPD ermöglicht >5% 13C‐Hyperpolarisation durch SABRE

Angewandte Chemie, EarlyView.
Mit „c‐OMPD“ entdeckten wir eine bislang unbekannte fünfgliedrige Lactolstruktur, die durch Homoaldolkondensation des zentralen Metaboliten Brenztraubensäure entsteht. Wir zeigen, dass das Cyclisierungsgleichgewicht für die Funktion von OMPD als MRT‐basierte pH‐Sonde von entscheidender Bedeutung ist, und erreichen erstmals eine 13C‐Polarisation von >5 %
Juanita Ferreira, Ivan A. Trofimov, Martin Grashei, Adriana Sacristán‐Martín, Alexander Huber, David Schleicher, Oleksiy Khavryuchenko, Franz Schilling, Andreas B. Schmidt, Max von Delius   +9 more
wiley   +1 more source

Conditional dependency of oncogenic KRAS in driving ketone body catabolism and pancreatic cancer growth. [PDF]

J Biol Chem
Wang R, Li X, Zhang T, Chen Y, Liu J, Wang Y, Wang X, Cao L, Lu Z, Ma L.   +9 more
europepmc   +1 more source

Fine Tuning of Catalyst Active Sites to Access Advanced Ultrahigh‐Melting Polyolefins

Angewandte Chemie, EarlyView.
A redesign of the active site of the pyridylamido hafnium (Hf) catalysts can enhance the performance of this catalyst family and unlock previously inaccessible polymer structures. When the catalyst is precontacted with allyltrimethylsilane the active species is modified and the catalyst experiences a new life becoming able to polymerize sterically ...
Fabio De Stefano, Olga D'Anania, Giovanni Talarico, Claudio De Rosa   +3 more
wiley   +1 more source

A randomized controlled trial of a multimodality digital health intervention to aid the delivery of the modified ketogenic diet therapy for epilepsy: The Keto eCoach trial protocol. [PDF]

Epilepsia Open
Kaul N, Vivash L, Chen S, King L, Johns H, Churilov L, Chen Z, Nicolo JP, Heaven D, Meredith E, Ervine R, Todd L, Zappa B, Ademi Z, Geethadevi GM, Erlichster M, Skafidas E, O'Brien TJ, Kwan P.   +18 more
europepmc   +1 more source