The Hidden Threat of Pharmaceuticals: Ketoprofen Degradation and Toxicity to Non-Target Organisms. [PDF]
MoleculesKetoprofen is a widely prescribed non-steroidal anti-inflammatory drug whose extensive global use, combined with limited biodegradability, has led to its increasing detection as a micropollutant in aquatic and terrestrial environments. Incomplete removal
Solski P, Guzik U, Wojcieszyńska D.
europepmc +2 more sources
Physical stability and dissolution of ketoprofen nanosuspension formulation: Polyvinylpyrrolidone and Tween 80 as stabilizers [PDF]
Pharmacia, 2023 This study was conducted to improve the dissolution of ketoprofen in nanosuspensions. Ketoprofen nanosuspensions were prepared by a solvent evaporation method using polyvinylpyrrolidone (PVP) and Tween 80 as stabilizers at varied ratios with ketoprofen ...
Tengku Ismanelly Hanum +3 more
doaj +3 more sources
Administration of ketoprofen in postpartum sows to control the incidence of post-parturient disorders and improve piglet survival rate [PDF]
Animal Bioscience, 2023 Objective Inflammation and pain management in postpartum hyperprolific sows is currently an important animal welfare issue in the swine industry. The present study investigates effects of ketoprofen treatment on the incidence of post-parturient disorders,
Suwicha Jeeraphokhakul +7 more
doaj +1 more source
Macedonian Veterinary Review, 2023 The objective of this study was to examine the effect of ketoprofen with or without combination with xylazine on the level of cyclooxygenase-2 in mice. The intraperitoneal (i.p.) dose of ketoprofen and xylazine that caused an analgesic response in half ...
Khalil Abdullah Khalil +2 more
doaj +1 more source
Materials Proceedings, 2023 The aim of this paper was to exactly quantify the amount of pure ketoprofen within a pharmaceutical by a newly developed ultraviolet (UV) spectrophotometric method.
Cristian-Catalin Gavat
doaj +1 more source
Symmetric dimethyl arginine and N-acetyl-β-D-glucosaminidase lysozimuria of proximal renal tubules as a target for nephrotoxicity in patients with rheumatoid arthritis treated with disease modifying antirheumatic drugs [PDF]
Journal of Nephropathology, 2013 Background: The aim of this study was to determine the effect of initial therapy with some disease modifying antirheumatic drugs (DMARDs) (Methotrexate and Ketoprofen) on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA ...
Dejan Spasovski +13 more
doaj +1 more source
Crystals, 2022 This study aims to improve the dissolution rate of ketoprofen by preparing multicomponent crystals with tromethamine. The multicomponent crystals (equimolar ratio) of ketoprofen and tromethamine were prepared by the solvent co-evaporation method.
Lili Fitriani +7 more
doaj +1 more source
Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal
Frontiers in Microbiology, 2023 Ketoprofen, a bicyclic non-steroidal anti-inflammatory drug commonly used in human and veterinary medicine, has recently been cited as an environmental contaminant that raises concerns for ecological well-being.
Elena Tyumina +9 more
doaj +1 more source
Evaluation of analgesic activity and acute toxicity of ketoprofen-nicotinamide multicomponent solids [PDF]
Pharmaceutical Sciences Asia, 2022 The objective of this study was to evaluate the analgesic activity and acute toxicity of the ketoprofennicotinamide multicomponent solid. The preparation of multicomponent solids was carried out by the solvent evaporation method. The characterization of
Yudi Wicaksono +4 more
doaj +1 more source
Pharmaceuticals, 2023 Ketoprofen is an anti-inflammatory agent that may cause gastric irritation if administered orally. Dissolving microneedles (DMN) can be a promising strategy to overcome this issue.
Delly Ramadon +8 more
doaj +1 more source