Use of gastroprotective agents in recommended doses in hospitalized patients receiving NSAIDs: a drug utilization study [PDF]
, 2006 OBJECTIVE: In recent years, studies investigated to what extend recommendations for co-prescribing gastroprotective agents in prevention of NSAID-induced gastrointestinal complications are followed in clinical practice.
Bilušić, Marinko +6 more
core +1 more source
Polyelectrolyte multilayer assembly bearing ketoprofen for transdermal delivery [PDF]
, 2009 A novel microencapsulation technology based on layer-by-layer assembly has been extensively studied and used for controlled delivery of drug microcrystal having poor aqueous solubility and low bioavailability.
Preeti Yadav +2 more
core +2 more sources
In vitro kinetic release study of ketoprofen enantiomers from alginate metal complexes
Future Journal of Pharmaceutical Sciences, 2021 Background To explore the release behavior of ketoprofen enantiomers from alginate-metal-complexes. Five mathematical models of drug release kinetics were investigated.
Ghaidaa Alkhayer +2 more
doaj +1 more source
Rheological characterization of molten polymer-drug dispersions as a predictive tool for pharmaceutical hot-melt extrusion processability [PDF]
, 2017 The aim of this study was to investigate (i) the influence of drug solid-state (crystalline or dissolved in the polymer matrix) on the melt viscosity and (ii) the influence of the drug concentration, temperature and shear rate on polymer crystallization ...
De Beer, Thomas +2 more
core +2 more sources
Middle East Fertility Society Journal, 2018 Objective: The study aims to evaluate the analgesic effect of oral ketoprofen prior to copper intrauterine device (IUD) insertion on pain perception during the insertion procedure.Study design: A randomized double-blind controlled trial (Clinical Trials.
Ahmed M. Abbas +3 more
doaj +1 more source
Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices
Advanced Science, EarlyView.This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee +4 more
wiley +1 more source
Phase Diagram and Thermodynamic Properties of Ketoprofen-Succinic Acid Binary Mixtures
Jurnal Ilmu Dasar, 2018 The equilibrium phase diagram and thermodynamic properties of a mixture of drugs and additives are information related to various possible interaction processes between components.
Yudi Wicaksono +2 more
doaj +1 more source
The effect of alcohol on the performance of lipase-immobilized enzymatic membrane reactor for esterification of (R,S)-ketoprofen [PDF]
, 2006 The effect of alcohols on the performance of lipase-immobilized enzymatic membrane reactor (EMR) for enantioselective esterification of (R,S)-ketoprofen has been studied. In this work, mixed solvent medium was used and the (R)-ketoprofen was reacted with
Bhatia, Subhash +3 more
core
Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Advanced Science, EarlyView.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
IN VITRO IRREVERSIBLE BINDING AND DEGRADATION OF (R)- AND (S)-KETOPROFEN GLUCURONIDES TO PLASMA PROTEINS [PDF]
Malaysian Journal of Pharmaceutical Sciences, 2007 This study describes the in vitro degradation studies of the diastereomeric ketoprofen glucuronides, under physiological conditions (pH 7.4, 37°C, (R)-ketoprofen glucuronide t½ = 30 min, (S)-ketoprofen glucuronide t½ = 70 min) and the irreversible ...
PETER J. HAYBALL, KELLIE L. TUCK
doaj