Results 31 to 40 of about 23,218 (270)
Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels
Journal of Lipid Research, 2010 Over the past several years, proprotein convertase subtilisin kexin type 9 (PCSK9) has gained significant attention as a key regulator of serum LDL-cholesterol (LDL-C) levels.
Jason S. Troutt +3 more
doaj +1 more source
Characterization of the Kexin-Like Maturase of Aspergillus niger [PDF]
Applied and Environmental Microbiology, 2000 ABSTRACT Secreted yields of foreign proteins may be enhanced in filamentous fungi through the use of translational fusions in which the target protein is fused to an endogenous secreted carrier protein. The fused proteins are usually separated in vivo by cleavage of an engineered Kex2 endoprotease recognition site at the fusion ...
R, Jalving +3 more
openaire +2 more sources
ComputersInstruction tuning plays a pivotal role in aligning large language models with diverse tasks, yet its effectiveness hinges on the interplay of data quality, domain composition, and training strategies.
Xungang Gu +8 more
doaj +1 more source
Evolution of a subtilisin-like protease gene family in the grass endophytic fungus
BMC Evolutionary Biology, 2009 Background Subtilisin-like proteases (SLPs) form a superfamily of enzymes that act to degrade protein substrates. In fungi, SLPs can play either a general nutritive role, or may play specific roles in cell metabolism, or as pathogenicity or virulence ...
Hesse Uljana +3 more
doaj +1 more source
Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
JACC: Case Reports, 2020 A 72-year-old man with coronary artery disease, statin intolerance, and chronic kidney disease stage IIIa was initiated on alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, and developed acute kidney injury.
June K. Pickett, MD +6 more
doaj +1 more source
Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease
International Journal of Molecular Sciences, 2022 Proprotein convertase subtilisin/kexin 6 (PCSK6) is a secreted serine protease expressed in most major organs, where it cleaves a wide range of growth factors, signaling molecules, peptide hormones, proteolytic enzymes, and adhesion proteins. Studies in Pcsk6-deficient mice have demonstrated the importance of Pcsk6 in embryonic development, body axis ...
Qingyu Wu, Shenghan Chen
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Non-Destructive Thickness Measurement of Energy Storage Electrodes via Terahertz Technology
SensorsPrecision thickness control in new energy electrode coatings is a critical determinant of battery performance characteristics. This study presents a non-destructive inspection methodology employing terahertz time-domain spectroscopy (THz-TDS) to achieve ...
Zhengxian Gao +10 more
doaj +1 more source
Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Brief Overview [PDF]
The American Journal of Medicine, 2017 Proprotein convertase subtilisin/kexin type 9 inhibitors serve as a valuable addition to the armamentarium of lipid-lowering agents and have promising potential. By inhibiting the proprotein convertase subtilisin/kexin type 9 enzyme, this novel molecule leads to increased low-density lipoprotein receptor density and decreased circulation of low-density
Zachary R, Noel, Craig J, Beavers
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Cost Effectiveness and Resource AllocationBackground Combined serplulimab and chemotherapy demonstrated improved clinical survival outcomes in patients with advanced esophageal squamous cell carcinoma (ESCC) and PD-L1 combined positive scores (CPS) ≥ 1.
Jiahui Li, Chaoqun Xu, Suyun Yuan
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source