Proprotein Convertase Subtilisin Kexin 9 Inhibitors [PDF]
Cardiology Clinics, 2018 High levels of low-density lipoprotein cholesterol (LDL-C) are directly associated with an increased risk of cardiovascular disease. Reducing LDL-C levels reduces the incidence of cardiovascular events. Several lipid-lowering approaches are available to achieve the LDL-C levels recommended by current guidelines, statins being the first-line therapy ...
A. Pirillo, A. L. Catapano
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Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
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Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors [PDF]
Canadian Medical Association Journal, 2019 PCSK9 is a protease that degrades hepatic LDL-C receptors. Evolocumab and alirocumab are fully human monoclonal antibodies administered as subcutaneous injections that inhibit PCSK9, preserving receptor availability to clear circulating LDL-C.[1][1],[2][2] In randomized, placebo-controlled ...
Derek, Leong, Peter E, Wu
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PCSK5 (Proprotein Convertase Subtilisin/Kexin Type 5) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2015 Review on PCSK5 (Proprotein Convertase Subtilisin/Kexin Type 5), with data on DNA, on the protein encoded, and where the gene is implicated.
Khatib, M, Demoures, B
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PCSK1 (proprotein convertase subtilisin/kexin type 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 PCSK1 is a serine protease involved in the proteolytic processing of a variety of protein precursors mainly neuropeptides and prohormones. In 1991, PC1/3; also known as PCSK1, PC1, PC3, and SPC3 was identified at the same time by two laboratories separately. The human and mouse PCSK1 genes are localized on chromosomes 5 and 13, respectively.
Demoures, Béatrice +2 more
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A three-player game analysis on industrial environmental pollution control [PDF]
E3S Web of Conferences, 2021 The environmental pollution of industrial enterprises has severely restricted the development of economy and society. In the face of serious industrial environmental pollution, this paper constructs a three-player game model including enterprises ...
Hou Kexin
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Suppressor of Cytokine Signaling-3 (SOCS-3) induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) expression in hepatic HepG2 cell line [PDF]
, 2015 The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the tumor necrosis factor (TNF-\u3b1).
Corsini, Alberto +7 more
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Processing of
mBio, 2018 Candida albicans is an opportunistic fungal pathogen responsible for superficial and life-threatening infections in humans. During mucosal infection, C. albicans undergoes a morphological transition from yeast to invasive filamentous hyphae that secrete ...
Jonathan P. Richardson +19 more
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Repetitive DNA is Functional and Encodes Parts of the Non‐Coding RNA Repertoire
Advanced Genetics, 2022 This is a commentary on the article by Eviatar Nevo and Kexin Li entitled “Sympatric Speciation in Mole Rats and Wild Barley and Their Genome Repeatome Evolution: A Commentary”, published recently in Advanced Genetics.
James A. Shapiro
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HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox". [PDF]
, 2016 BackgroundProprotein convertase subtilisin kexin 9 (PCSK9) inhibitors reduce low-density lipoprotein cholesterol (LDL-C) and improve outcomes in the general population.
Deeks, Steven +10 more
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