Results 31 to 40 of about 48,363 (248)
Frontiers in Immunology, 2023 BackgroundImmunogenic cell death (ICD) is a form of cell death that elicits immune responses against the antigens found in dead or dying tumor cells. Growing evidence implies that ICD plays a significant role in triggering antitumor immunity.
Yirui Kuang +8 more
doaj +1 more source
On Strengthening the Dissemination of Positive Chinese Traditional Culture in Colleges and Universities in the New Media Era [PDF]
SHS Web of Conferences, 2023 General Secretary Xi Jinping once profoundly pointed out that “Positive Chinese traditional culture is the root and soul of the everlasting Chinese nation”.1 However, the traditional communication mode of positive Chinese traditional culture is facing ...
Li Kexin
doaj +1 more source
Proprotein convertase subtilisin/kexin type 9 and lipid metabolism [PDF]
Current Opinion in Lipidology, 2019 Purpose of review The purpose of this review is to highlight the recent findings of one of the most promising therapeutic targets in LDL cholesterol (LDL-C) management, proprotein convertase subtilisin/kexin type 9 (PCSK9).
Stefano, Spolitu +3 more
openaire +2 more sources
Use of PCSK9 Inhibitors in Solid Organ Transplantation Recipients
JACC: Case Reports, 2020 Standard lipid-lowering therapies in solid organ transplantations pose challenges due to interactions with immunosuppressants. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid-lowering therapies with ...
Bruce A. Warden, PharmD +5 more
doaj +1 more source
Proprotein Convertase Subtilisin/Kexin 9 Inhibitors
Journal of Cardiovascular Pharmacology and Therapeutics, 2014 Proprotein convertase subtilisin/kexin 9 (PCSK9) is part of the proteinase K subfamily of subtilases and plays a key role in lipid metabolism. It increases degradation of the low-density lipoprotein receptor (LDL-R), modulates cholesterol metabolism and transport, and contributes to the production of apolipoprotein B (apoB) in intestinal cells ...
Simona, Dragan +2 more
openaire +2 more sources
Lipoprotein(a) and proprotein convertase subtilisin/kexin type 9 inhibitors [PDF]
Clinical Research in Cardiology Supplements, 2019 Lipoprotein(a) (Lp(a)) is an internationally accepted independent atherogenic risk factor. Details about its synthesis, many aspects of composition and clearance from the bloodstream are still unknown. LDL receptor (LDLR) (and probably other receptors) play a role in the elimination of Lp(a) particles.
Julius, U +4 more
openaire +2 more sources
Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels
Journal of Lipid Research, 2010 Over the past several years, proprotein convertase subtilisin kexin type 9 (PCSK9) has gained significant attention as a key regulator of serum LDL-cholesterol (LDL-C) levels.
Jason S. Troutt +3 more
doaj +1 more source
The 1(st) and the 2(nd) Italian Consensus Conferences on low-density lipoprotein-apheresis. A practical synopsis and update [PDF]
, 2016 The clinical indications and guidelines for low-density lipoprotein (LDL)-apheresis set by the 1(st) Italian Consensus Conference held in Ostuni in 1990 and completed in 1992, but never published, are reported schematically.
Stefanutti, Claudia
core +1 more source
Characterization of the Kexin-Like Maturase of Aspergillus niger [PDF]
Applied and Environmental Microbiology, 2000 ABSTRACT Secreted yields of foreign proteins may be enhanced in filamentous fungi through the use of translational fusions in which the target protein is fused to an endogenous secreted carrier protein. The fused proteins are usually separated in vivo by cleavage of an engineered Kex2 endoprotease recognition site at the fusion ...
R, Jalving +3 more
openaire +2 more sources
ComputersInstruction tuning plays a pivotal role in aligning large language models with diverse tasks, yet its effectiveness hinges on the interplay of data quality, domain composition, and training strategies.
Xungang Gu +8 more
doaj +1 more source