Results 61 to 70 of about 48,363 (248)

Proprotein convertase subtilisin/kexin type 9 in kidney disease

Nephrology Dialysis Transplantation, 2019
Abstract Chronic kidney disease (CKD) is associated with a substantially increased risk for the development of atherosclerotic cardiovascular (CV) disease. Accordingly, CV mortality is increased even in the earliest stages of CKD. In the general population and in CKD patients, high plasma levels of low-density lipoprotein cholesterol ...
David, Schmit, Danilo, Fliser, Thimoteus, Speer   +2 more
openaire   +2 more sources

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

SINVAD: Search-based Image Space Navigation for DNN Image Classifier Test Input Generation

, 2020
The testing of Deep Neural Networks (DNNs) has become increasingly important as DNNs are widely adopted by safety critical systems. While many test adequacy criteria have been suggested, automated test input generation for many types of DNNs remains a ...
Goodfellow Ian, Goodfellow Ian J., Oord Aaron Van, Simonyan Karen   +3 more
core   +1 more source

Oxidative Fast Pyrolysis Enabling Autothermal Production of Porous Functionalized Biochar and Anhydrosugar/Phenol‐Rich Bio‐Oil From Biomass

Carbon Energy, EarlyView.
Oxidative fast pyrolysis of biomass enables autothermal production of value‐added products. ABSTRACT Oxidative fast pyrolysis can potentially overcome the heat‐supply bottleneck of conventional fast pyrolysis by enabling autothermal operation while also tailoring product quality through controlled oxygen addition.
Bin Li, Mengge Song, Sunwen Xia, Kexin Jia, Wojciech Jerzak, Yusuf Makarfi Isa, Dongjing Liu, Xing Xie, Qingfa Zhang, Zhong Ma, Mingfeng Wang, Weiwei Liu, Shihong Zhang, Haiping Yang, Rock Keey Liew, Su Shiung Lam   +15 more
wiley   +1 more source

Machine learning‐based prediction of elevated N terminal pro brain natriuretic peptide among US general population

ESC Heart Failure, Volume 12, Issue 2, Page 859-868, April 2025.
Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Yuichiro Mori, Shingo Fukuma, Kyohei Yamaji, Atsushi Mizuno, Naoki Kondo, Kosuke Inoue   +5 more
wiley   +1 more source

Pricing Models for a Two-Period Manufacturing and Remanufacturing Process Under Carbon Cap and Trade Mechanism

IEEE Access, 2023
Under carbon cap and trade mechanism, collecting ratio and carbon cap seriously affect the decision of a manufacturer in a closed-loop supply chain. This paper constructs pricing models for manufacturing and remanufacturing products in the presence of ...
Kexin Lou
doaj   +1 more source

Proprotein Convertase Subtilisin/Kexin Type 9 [PDF]

The American Journal of Pathology, 2021
Chiara Macchi, Nicola Ferri, Cesare R. Sirtori, Alberto Corsini, Maciej Banach, Massimiliano Ruscica   +5 more
openaire   +1 more source

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice[S]

Journal of Lipid Research, 2015
Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Herein,
Anna Roubtsova, Ann Chamberland, Jadwiga Marcinkiewicz, Rachid Essalmani, Ali Fazel, John J. Bergeron, Nabil G. Seidah, Annik Prat   +7 more
doaj   +1 more source

Bizard: A Community‐Driven Platform for Accelerating and Enhancing Biomedical Data Visualization

iMetaMed, EarlyView.
Bizard is an open‐source platform that consolidates customizable biomedical data visualization scripts, providing an intuitive interface, tutorials, and community support to enhance analysis and accelerate progress in precision medicine. https://openbiox.github.io/Bizard/ ABSTRACT Biomedical research increasingly relies on heterogeneous, high ...
Kexin Li, Hu Zheng, Kexin Huang, Yinying Chai, Yujie Peng, Chunyang Wang, Xuyang Yi, Zilun Jin, Hong Yang, Yun Peng, Ying Shi, Xinhe Lu, Jiarui Bian, Yirun Wang, Rongao Kou, Demin Gao, Hanbo Zhao, Juan Zhang, Dan Huang, Kaiyu Zhu, Chenxu Wu, Zeruo Yang, Zheng Kuang, Bin Yan, Mo Liu, Zhiwei Bao, Yuzhong Peng, Benben Miao, Jianming Zeng, Jianfeng Li, Peng Luo, Shixiang Wang   +31 more
wiley   +1 more source

The State of Black Immigrants Part II: Black Immigrants in the Mass Criminalization System [PDF]

, 2016
Black immigrants are one of the fastest growing demographics in the United States. Nonetheless, this group remains a novelty in the broader immigration discourse.
Juliana MorganTrostle, Kexin Zheng
core