Results 71 to 80 of about 23,218 (270)

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Increased Valency Improves Inhibitory Activity of Peptides Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

, 2021
Benjamin J. Tombling, Carmen Lammi, Carlotta Bollati, Anna Anoldi, David J. Craik, Conan K. Wang   +5 more
openalex   +2 more sources

High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases

The FEBS Journal, EarlyView.
High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywon, Migmar Tsamchoe, Anastasia Tsatoumas, Stephanie K. Petrillo, Nabil G. Seidah, Anthoula Lazaris, Peter Metrakos   +9 more
wiley   +1 more source

Transforming hypercholesterolemia management: Spotlight on PCSK9 peptide vaccines

Cell Reports Medicine
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a therapeutic target for dyslipidemia and atherosclerotic cardiovascular disease (ASCVD). Two recent studies published by Fang et al.1 and Zhang et al.2 in Cell Reports Medicine and Cell Reports ...
Amirhossein Sahebkar, Maciej Banach
doaj   +1 more source

Research on incentive and technological innovation models of biopharmaceutical companies [PDF]

BIO Web of Conferences
This article selects biopharmaceutical enterprises listed in high-tech industry as samples, using the Heckman selection model effectively avoid sample bias and according to linear analysis, this research tests the influence between senior management ...
Kexin Wang
doaj   +1 more source

Overreliance on Orthographic Similarity in L2‐Japanese Conceptual Processing by L1‐Chinese Learners

International Journal of Applied Linguistics, EarlyView.
ABSTRACT Orthographic and phonological similarities between first (L1) and second (L2) languages can facilitate L2 processing. Particularly, L1‐Chinese learners of L2‐Japanese can benefit from the shared morphosyllabic Chinese characters (Japanese kanji/Chinese hanzi) because of their similar orthographies.
Xuehan Zhao, Kexin Xiong, Sachiko Kiyama
wiley   +1 more source

The MdICE1/MdFAMA‐MdTYDC Transcriptional Module Confers Cold Tolerance by Regulating Dopamine Metabolism in Apple

Plant Biotechnology Journal, EarlyView.
ABSTRACT Low temperature is a critical abiotic stress that imposes major constraints on the sustainable development of the fruit tree industry. Although exogenous dopamine has been shown to enhance cold tolerance in plants, its molecular mechanisms in apple (Malus domestica) remain poorly understood.
Kexin Tan, Xinyang Song, Ziyi Xu, Hongzhen Zhu, Ying Zhang, Shuhan Xu, Zhijun Zhang, Pengmin Li, Fengwang Ma, Chao Li   +9 more
wiley   +1 more source

P8 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 LEVELS AND ARTERIAL FUNCTION

Artery Research, 2017
Purpose/Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are modestly but significantly associated with increased risk of total cardiovascular events.
Losif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, John Skoumas, Nikitas Skliros, Magkas Nikolaos, Antigoni Miliou, Dimitrios Tousoulis   +7 more
doaj   +1 more source

Proprotein Convertase Subtilisin/kexin Type 9 Links Inflammation to Vascular Endothelial Cell Dysfunction [PDF]

, 2021
Thorsten M. Leucker, Nuria Amat-Codina, Stephen P. Chelko, Gary Gerstenblith   +3 more
openalex   +3 more sources

Potential of PCSK9 as a new target for the management of LDL cholesterol

Research Reports in Clinical Cardiology, 2015
Guiliana Mombelli, Samuela Castelnuovo, Chiara PavanelloCardiovascular Department, Dyslipidemia Center, Azienda Ospedaliera Niguarda Cà Granda, Milan, ItalyAbstract: A large proportion of patients at high risk for cardiovascular disease continue ...
Mombelli G, Castelnuovo S, Pavanello C
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