Results 91 to 100 of about 505,343 (301)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Human resource management in local governments
Management Letters/Cuadernos de Gestión, 2012 Literature highlights the key role that organizations' workforce has in companies' performance. It is also emphasized that human resource management is a source of competitive advantage. However, although this topic has been widely studied in the private
María Isabel Barba Aragón +1 more
doaj
Economic Performance of the Economy of Kosovo and Metohija [PDF]
Management and Economics ReviewThe problem of analysing the factors of the dynamics of the economic performance of every economy, which means the economy of the southern provinces of Serbia, the economy of Kosovo and Metohija, is continuously very current, challenging, significant ...
Radojko LUKIC
doaj +1 more source
IEEE Access, 2020 With the wide use of online social networks (OSNs), the problem of data privacy has attracted a lot of attention from not only the research community but also the general public.
Guanglai Guo +4 more
doaj +1 more source
Strategic Collaborative Communication by Key Account Representatives
Journal of Personal Selling & Sales Management, 2002 Following research linking collaborative aspects of communication to performance, this exploratory study empirically examines a model of key account representative (KAR) strategic communication practices and their effects on outcomes (i.e., role ...
R. Schultz, K. Evans
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Explanations for the gap between management accounting rules and routines: An institutional approach
Revista de Contabilidad: Spanish Accounting Review, 2014 This is a longitudinal in‐depth case study that was conducted within a Portuguese public sector organization, the National Postal Service of Portugal, where two management accounting innovations were implemented.
Rui Robalo
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source