Results 71 to 80 of about 2,764,347 (308)

Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix

Drug Delivery, 2017
In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphatidylethanolamine-poly(ethylene glycol)2000 (DSPE-PEG) as absorption enhancer and hydroxy propyl methyl cellulose (HPMC) as crystallization inhibitor to ...
Yang Guo, Ting Zhong, Xiao-Chuan Duan, Shuang Zhang, Xin Yao, Yi-Fan Yin, Dan Huang, Wei Ren, Qiang Zhang, Xuan Zhang   +9 more
doaj   +1 more source

Localized Mobility Management for SDN-Integrated LTE Backhaul Networks [PDF]

, 2015
Small cell (SCell) and Software Define Network (SDN) are two key enablers to meet the evolutional requirements of future telecommunication networks, but still on the initial study stage with lots of challenges faced.
Qi, Yinan, Quddus, Atta Ul, Wang, Dongyao, Zhang, Lei   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

Nature Communications, 2022
Detailed quantification of nanoparticle distribution in tumor tissues can provide the prediction of drug delivery efficacy and therapeutic outcome. Here the authors develop a pH/light dual responsive monochromatic ratiometric-imaging nanoparticle which ...
Yue Yan, Binlong Chen, Qingqing Yin, Zenghui Wang, Ye Yang, Fangjie Wan, Yaoqi Wang, Mingmei Tang, Heming Xia, Meifang Chen, Jianxiong Liu, Siling Wang, Qiang Zhang, Yiguang Wang   +13 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

Nature Communications
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this.
Kexin Su, Lu Shi, Tao Sheng, Xinxin Yan, Lixin Lin, Chaoyang Meng, Shiqi Wu, Yuxuan Chen, Yao Zhang, Chaorong Wang, Zichuan Wang, Junjie Qiu, Jiahui Zhao, Tengfei Xu, Yuan Ping, Zhen Gu, Shuai Liu   +16 more
doaj   +1 more source

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

Drug Delivery, 2021
Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD)
Xiao-Chuan Duan, Li-Yuan Peng, Xin Yao, Mei-Qi Xu, Hui Li, Shuai-Qiang Zhang, Zhuo-Yue Li, Jing-Ru Wang, Zhen-Han Feng, Guang-Xue Wang, Ai Liao, Ying Chen, Xuan Zhang   +12 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

One Stone Four Birds: A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy

Nano-Micro Letters, 2020
Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors. However, the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment (TME) and the insufficient ...
Chao Hong, Jianming Liang, Jiaxuan Xia, Ying Zhu, Yizhen Guo, Anni Wang, Chunyi Lu, Hongwei Ren, Chen Chen, Shiyi Li, Dan Wang, Huaxing Zhan, Jianxin Wang   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source