Results 51 to 60 of about 911,306 (169)

Engineered microbial platform confers resistance against heavy metals via phosphomelanin biosynthesis

Nature Communications
Environmental concerns are increasingly fueling interest in engineered living materials derived from microbial sources. Melanin biosynthesis in microbes, particularly facilitated by recombinant tyrosinase expression, offers sustainable protection for the
Xiaokang Ren, Luyang Zhao, Jintao Shen, Peng Zhou, Kaili Zhao, Chengqian Yuan, Ruirui Xing, Xuehai Yan   +7 more
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Improved service delivery in key areas

, 2020
Coverage ...
openaire   +2 more sources

Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus.
Zhiyang Ke, Han Guo, Xi Zhu, Yun Jin, Yuan Huang   +4 more
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Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

Acta Pharmaceutica Sinica B, 2019
Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight ...
Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Xian Tang, Jingdong Rao, Sheng Yin, Zhirong Zhang, Man Li, Qin He   +9 more
doaj   +1 more source

Rational fusion design inspired by cell-penetrating peptide: SS31/S-14 G Humanin hybrid peptide with amplified multimodal efficacy and bio-permeability for the treatment of Alzheimer's disease

Asian Journal of Pharmaceutical Sciences
Alzheimer's disease is a neurodegenerative disease induced by multiple interconnected mechanisms. Peptide drug candidates with multi-modal efficacy generated from fusion strategy are suitable for addressing multi-facet pathology.
Kang Qian, Peng Yang, Yixian Li, Ran Meng, Yunlong Cheng, Lingling Zhou, Jing Wu, Shuting Xu, Xiaoyan Bao, Qian Guo, Pengzhen Wang, Minjun Xu, Dongyu Sheng, Qizhi Zhang   +13 more
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Macrophage based drug delivery: Key challenges and strategies

Bioactive Materials
As a natural immune cell and antigen presenting cell, macrophages have been studied and engineered to treat human diseases. Macrophages are well-suited for use as drug carriers because of their biological characteristics, such as excellent biocompatibility, long circulation, intrinsic inflammatory homing and phagocytosis.
Qian Guo, Zhong-Ming Qian
openaire   +3 more sources

In vivo fluorescence imaging of nanocarriers in near-infrared window II based on aggregation-caused quenching

Journal of Nanobiotechnology
Accurate fluorescence imaging of nanocarriers in vivo remains a challenge owing to interference derived mainly from biological tissues and free probes. To address both issues, the current study explored fluorophores in the near-infrared (NIR)-II window ...
Zichen Zhang, Chang Liu, Yi Lu, Weili Zhao, Quangang Zhu, Haisheng He, Zhongjian Chen, Wei Wu   +7 more
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Preparation of a benziodazole-type iodine(III) compound and its application as a nitrating reagent for synthesis of furazans via a copper-catalyzed cascade process

Communications Chemistry
The existing hypervalent I(III) reagents bearing ONO2 group are limited in types and their applications primarily focused on the nitrooxylation reactions featuring a fully-exo fashion. Herein, a benziodazole-type O2NO-I(III) compound was prepared and its
Zhifang Yang, Jun Xu, Yuli Sun, Xuemin Li, Bohan Jia, Yunfei Du   +5 more
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Microneedle‐Mediated Cell Therapy

Advanced Science
Microneedles have emerged as a promising platform for transdermal drug delivery with prominent advantages, such as enhanced permeability, mitigated pain, and improved patient adherence. While microneedles have primarily been employed for delivering small
Ziqi Gao, Tao Sheng, Wentao Zhang, Huiheng Feng, Jicheng Yu, Zhen Gu, Yuqi Zhang   +6 more
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High intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming

Acta Pharmaceutica Sinica B
Cold tumors have a poor response to tumor immunotherapy due to low immune cell infiltration and the ability to evade immune attacks. Converting cold tumors into hot tumors can enhance the clinical effectiveness of anti-tumor immunotherapy. High-intensity
Xuejing Li, Jiayi Wu, Ruizhe Xu, Xifeng Qin, Siyu Wang, Wuli Yang, Zhiqing Pang   +6 more
doaj   +1 more source