Results 151 to 160 of about 1,515,339 (267)

Resveratrol Alleviates Arsenic-Induced Liver Fibrosis in Rats by Correcting SIRT1-Mediated Disorder of Hepatic Bile Acid Metabolism. [PDF]

Int J Mol Sci
Wang Q, Chen H, Ran Q, Hu F, Fu Q, Ma L.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Toxicological Effects and Health Impacts of Per- and Polyfluoroalkyl Substances (PFAS) in Humans. [PDF]

Toxics
Ma J, Gao G, Meng B, Wei X, Zhao L, Ge Z.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Enhancing Therapist Training in the Delivery of Exposure Therapy for Individuals with Anxiety Disorders Using Virtual Reality Simulation: Randomized Feasibility Trial. [PDF]

JMIR Med Educ
Kemp J, Rosen A, Kim H, Adams Larsen M, Benito K, Freeman J, Machan J, Tuerk P.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Metabolomic profiling of diatoms reveals distinct impacts of silver nanoparticles and ions.

Environ Sci Nano
Kantarciyan A, Segovia-Campos I, Marelja M, Gasco R, Li W, Keller AA, Slaveykova VI.   +6 more
europepmc   +1 more source

Aristolochic Acid and Hepatocellular Carcinoma: A Critical Review of Genotoxic and Inflammatory Mechanisms. [PDF]

Int J Mol Sci
Wang Y, Zhang Y, Ren T, Yuan L, Geng X.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Unraveling the molecular landscape of chronic radiation injury: From oxidative stress signaling to translational modeling (Review). [PDF]

Int J Mol Med
Xi Z, Li X, Yang C, Wang L, Mao J, Liu Q, Liu C, Li Q, Hou Y, Wan J, Yang C, Sun F, Yu C, Wang M, Yuan B, Liu Y, Hu Q, Zhang L, Li X, Li X.   +19 more
europepmc   +1 more source