Results 201 to 210 of about 1,515,339 (267)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Maternal microRNAs linked to birth deficits due to prenatal alcohol exposure are dominant modifiers of gene expression in invasive trophoblast cells. [PDF]

Front Cell Dev Biol
Upreti D, Chambers CD, Miranda RC.
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Biphasic Memory Impairment and Recovery After Sevoflurane Exposure Are Associated With Time-Dependent Hippocampal α5-GABAAR Remodeling. [PDF]

CNS Neurosci Ther
Wang S, Chen L, Wang S, Zhang C, Zhang M, Wang Z, Dong J, Liu Q, Dong Z, Wang X, Dong Y, Luo Y, Wang Y, Yin Y.   +13 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Bronchial mucosal nuclear transcription factor expression and inflammatory response in humans after exposure to wood smoke. [PDF]

Part Fibre Toxicol
Hansson A, Friberg M, Rankin G, Pourazar J, Uski O, García-López N, Boman C, Blomberg A, Behndig A, Sandström T, Muala A.   +10 more
europepmc   +1 more source

Multi-scale analysis reveals key targets mediating BPA-induced sensorineural hearing loss. [PDF]

Medicine (Baltimore)
Yan X, Xuan J, Peng J.
europepmc   +1 more source

Radon-Induced Radiation Biomarkers: A Scoping Review from Exposure Dosimetry to Early Biological Effects on the Lung. [PDF]

Int J Mol Sci
Rathebe PC, Kholopo M.
europepmc   +1 more source

Residential green space mitigates genetic susceptibility to incident irritable bowel syndrome in a prospective cohort of 376 749 individuals. [PDF]

J Glob Health
Kou Z, Li R, Wang J, Shao Z, Feng J, Wei M, Fu T, Chen L, Zheng G, Lin H, Liu K.   +10 more
europepmc   +1 more source

Role of gut microbiota dysbiosis in podophyllotoxin-induced neurotoxicity in zebrafish: linking purine metabolism to synaptic dysfunction. [PDF]

BMC Microbiol
Ru Y, Yu Y, Liu C, Liu Y, Liu D, Chen R, Chen X, Bai X, Jiang T, Duan J.   +9 more
europepmc   +1 more source