Results 61 to 70 of about 593,784 (199)

Verrouillage professionnel

open access: yesRevue d'anthropologie des connaissances, 2014
Recent challenges such as sustainable development and climate change suggest engineers to focus on societal issues. However, as this case study of structural design shows, professional arrangements within the construction field constrain engineers ...
Andrew Chilvers, Sarah Bell
doaj   +1 more source

Censorship: the Key to Lock-In? [PDF]

open access: yes
Markets for information and entertainment are frequently characterized by increasing returns to scale in production and distribution. This implies that incumbent technologies enjoy an advantage over newcomer technologies; such markets can become locked ...
Brendan M. Cunningham
core  

Adaptive Lock-Free Data Structures in Haskell: A General Method for Concurrent Implementation Swapping

open access: yes, 2017
A key part of implementing high-level languages is providing built-in and default data structures. Yet selecting good defaults is hard. A mutable data structure's workload is not known in advance, and it may shift over its lifetime - e.g., between read ...
Chen, Chao-Hong   +2 more
core   +1 more source

Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?

open access: yesLipids in Health and Disease
Disturbances in cholesterol homeostasis have been associated with ASD. Lipid rafts are central in many transmembrane signaling pathways (including mTOR) and changes in raft cholesterol content affect their order function.
Clifford Lingwood
doaj   +1 more source

Supporting energy technology deployment while avoiding unintended technological lock-in: a policy design perspective

open access: yesEnvironmental Research Letters, 2018
Technology deployment policies can play a key role in bringing early-stage energy technologies to the market and reducing their cost along their learning curves.
Leonore Haelg   +2 more
doaj   +1 more source

Solvent fluctuations induce non-Markovian kinetics in hydrophobic pocket-ligand binding

open access: yes, 2016
We investigate the impact of water fluctuations on the key-lock association kinetics of a hydrophobic ligand (key) binding to a hydrophobic pocket (lock) by means of a minimalistic stochastic model system.
Dzubiella, Joachim   +2 more
core   +1 more source

The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

open access: yesActa Chimica Slovenica, 2017
Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj   +1 more source

A Template for Implementing Fast Lock-free Trees Using HTM

open access: yes, 2017
Algorithms that use hardware transactional memory (HTM) must provide a software-only fallback path to guarantee progress. The design of the fallback path can have a profound impact on performance.
Brown T.   +4 more
core   +1 more source

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