Results 61 to 70 of about 6,742,422 (376)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Quantum-classical correspondence in circularly polarized high harmonic generation [PDF]
, 2013 Using numerical simulations, we show that atomic high order harmonic generation, HHG, with a circularly polarized laser field offers an ideal framework for quantum-classical correspondence in strong field physics.
Bandrauk, A. D. +4 more
core +4 more sources
Remote SensingAs crucial water conservancy projects, ship locks play a key role in flood control, shipping, water resource allocation, and promoting regional economic development, making them an indispensable part of the modern water transportation system.
Bingsun Chen +9 more
doaj +1 more source
Portable appliance security apparatus [PDF]
, 1981 An apparatus for securing a small computer, or other portable appliance, against theft is described. It is comprised of a case having an open back through which the computer is installed or removed. Guide members in the form of slots are formed in a rear
Kerley, J. J.
core +1 more source
Lock cohorting: A general technique for designing NUMA locks [PDF]
, 2012 Multicore machines are quickly shifting to NUMA and CC-NUMA architectures, making scalable NUMA-aware locking algorithms, ones that take into account the machines' non-uniform memory and caching hierarchy, ever more important.
Dice, David +2 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Opening up public data should be an urgent priority for the government and could lead to considerable economic benefits [PDF]
, 2012 There is no longer a reasonable justification for keeping publicly funded data under lock and key. With the government ostensibly committed to transparency, Chris Yiu argues that opening up public data is a must, and could have solid economic and ...
Yiu, Chris
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Silences in the boom: coal seam gas, neoliberalizing discourse, and the future of regional Australia
Journal of Political Ecology, 2014 In high-stakes resource use struggles currently playing out across the world, different beliefs about economics and "growth-first" regional development underpin decisions and dynamics that have far-reaching consequences.
Alexandra Mercer +2 more
doaj +1 more source
Health Care Coverage: Job Lock and the Potential Impact of the Patient Protection and Affordable Care Act [PDF]
, 2011 [Excerpt] The majority of Americans—about 55 percent in 2010—rely on employer-sponsored health care coverage, which is largely subsidized by most employers and thus less costly to employees than coverage purchased by individuals on their own.
United States Government Accountability Office
core +2 more sources