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Recent challenges such as sustainable development and climate change suggest engineers to focus on societal issues. However, as this case study of structural design shows, professional arrangements within the construction field constrain engineers ...
Andrew Chilvers, Sarah Bell
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Censorship: the Key to Lock-In? [PDF]
Markets for information and entertainment are frequently characterized by increasing returns to scale in production and distribution. This implies that incumbent technologies enjoy an advantage over newcomer technologies; such markets can become locked ...
Brendan M. Cunningham
core
A key part of implementing high-level languages is providing built-in and default data structures. Yet selecting good defaults is hard. A mutable data structure's workload is not known in advance, and it may shift over its lifetime - e.g., between read ...
Chen, Chao-Hong +2 more
core +1 more source
Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?
Disturbances in cholesterol homeostasis have been associated with ASD. Lipid rafts are central in many transmembrane signaling pathways (including mTOR) and changes in raft cholesterol content affect their order function.
Clifford Lingwood
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Technology deployment policies can play a key role in bringing early-stage energy technologies to the market and reducing their cost along their learning curves.
Leonore Haelg +2 more
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Multi-order analytical solving computation of rainstorm causal decomposition during typhoons using a designed key-lock quasi-Newton optimizing derivation. [PDF]
Huang CL, Hsu NS, Yao CH, Lo WC.
europepmc +1 more source
Solvent fluctuations induce non-Markovian kinetics in hydrophobic pocket-ligand binding
We investigate the impact of water fluctuations on the key-lock association kinetics of a hydrophobic ligand (key) binding to a hydrophobic pocket (lock) by means of a minimalistic stochastic model system.
Dzubiella, Joachim +2 more
core +1 more source
The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry
Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
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Development of highly sensitive metal-ion chemosensor and key-lock anticounterfeiting technology based on oxazolidine. [PDF]
Razavi B +2 more
europepmc +1 more source
A Template for Implementing Fast Lock-free Trees Using HTM
Algorithms that use hardware transactional memory (HTM) must provide a software-only fallback path to guarantee progress. The design of the fallback path can have a profound impact on performance.
Brown T. +4 more
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