Results 41 to 50 of about 6,012 (207)

Yacton and mexicor influence on prooxidant-antioxidant homeostasis and protein synthesis in the myocardium of rats in conditions of doxorubicin cardiomyopathy

Zaporožskij Medicinskij Žurnal, 2015
Doxorubicin, which is included in the scheme of cancer treatment, possesses cardiotoxicity that requires effective cardioprotectors searching. Aim.
E. A. Raketskaya , I. S. Chekman, N. A. Gorchakova   +2 more
doaj   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Record‐High Performance Hyperfluorescent OLEDs Achieved via Electronic Structure Control of Chlorine‐Diversified MR‐TADF Emitters

Advanced Science, EarlyView.
A late‐stage diversification strategy for the benchmark MR‐TADF emitter ω‐DABNA enables precise electronic structure control via chlorine‐activated functionalization. The resulting derivatives achieve tunable emission from 523 to 533 nm with record‐high EQE1000 up to 34.0% and excellent color purity (CIEy = 0.70–0.73), establishing a versatile platform
Taehwan Lee, Junki Ochi, Shigetada Uemura, Feiran Liu, Jiping Hao, Yasuhiro Kondo, Masahiro Hayakawa, Takuji Hatakeyama   +7 more
wiley   +1 more source

A functional inequality on the boundary of static manifolds [PDF]

, 2016
On the boundary of a compact Riemannian manifold $(\Omega, g)$ whose metric $g$ is static, we establish a functional inequality involving the static potential of $(\Omega, g)$, the second fundamental form and the mean curvature of the boundary $\partial \
Kwong, Kwok-Kun, Miao, Pengzi
core   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update

Clinical Pharmacology &Therapeutics, EarlyView.
Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard, Matthias Schwab, Michelle Whirl‐Carrillo, Ann M. Moyer, Guilherme Suarez‐Kurtz, Ching‐Hon Pui, C. Michael Stein, Teri E. Klein, Claire Spahn, Sooyeon Kwon, Juanda Leo Hartono, Nanne K. de Boer, Tariq Ahmad, Federico Guillermo Antillon‐Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E. J. Yeoh, Kjeld Schmiegelow, Jun J. Yang   +18 more
wiley   +1 more source

Evaluación del proceso de prensado en la fabricación de bloques de tierra comprimida

Informes de la Construccion
Este trabajo pretende esclarecer los aspectos fundamentales del proceso de compresión de los bloques de tierra comprimida (BTC) y de las máquinas desarrolladas para tal fin.
Santiago Cabrera, Gonzalo Darras, Nicolás Losa   +2 more
doaj   +1 more source

Statistical expansions and locally uniform Fréchet differentiability [PDF]

, 1991
Estimators which have locally uniform expansions are shown in this paper to be asymptotically equivalent to M-estimators. The M-functionals corresponding to these M-estimators are seen to be locally uniformly Fréchet differentiable.
Bednarski, T., Clarke, B.R., Kolkiewicz, W.   +2 more
core   +2 more sources

Analytical soliton solutions and dynamic behaviors of a fractional nonlinear model in relativistic wave mechanics [PDF]

AIP Advances
This article studied the quadratic fractional Klein–Fock–Gordon (KFG) equation in (1 + 1)-dimensions and solved it using the ϕ6-model expansion method.
Md. Ruhul Amin, Mohammad Safi Ullah, Md. Ghulam Murtaza Talukder   +2 more
doaj   +1 more source

Boundary conditions in the Unruh problem [PDF]

, 1999
We have analyzed the Unruh problem in the frame of quantum field theory and have shown that the Unruh quantization scheme is valid in the double Rindler wedge rather than in Minkowski spacetime.
A. I. Nikishov, A. M. Fedotov, A. M. Fedotov, B. M. Karnakov, B. S. Kay, Cl. Gabriel, D. G. Boulware, D. N. Klyshko, D. V. L’vov, D. W. Sciama, G. L. Sewell, H. C. Rosu, H. Reeh, J. J. Bisognano, J. S. Dowker, K.-P. Marzlin, M. Beciu, M. I. Kontorovich, N. B. Narozhny, N. Narozhny, P. C. W. Davies, P. Candelas, P. Martin, R. Haag, R. J. Kubo, R. Wald, S. A. Fulling, S. A. Fulling, S. Deser, S. M. Barett, S. M. Christensen, S. W. Hawking, Sh. Takagi, T. D. Lee, U. Gerlach, V. A. Belinskii, V. A. Belinskii, V. D. Mur, V. D. Mur, V. L. Ginzburg, W. G. Unruh, W. G. Unruh, W. Israel, W. Rindler, W. Troost, Ya. B. Zel’dovich   +45 more
core   +2 more sources

lessons drawn from the experiences of the International Court of Justice and the Appellate Body of the World Trade Organisation [PDF]

, 2020
The guarantee of judicial independence is undoubtedly one of the most important institutional design features of international courts and tribunals. An independence deficit can adversely impact a court’s authority, create a crisis of legitimacy, and ...
Gulati, Rishi
core   +1 more source