Results 51 to 60 of about 233,700 (287)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors

European Journal of Breast Health, 2019
Objective:The clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. The aim of study is to find the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and ...
Gül Kanyılmaz, Berrin Benli Yavuz, Meryem Aktan, Mustafa Karaağaç, Mehmet Uyar, Sıddıka Fındık   +5 more
doaj   +1 more source

Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer

Breast, 2020
Objectives: The proliferative activity of the Ki-67 index is important in decision-making of adjuvant treatments in early breast cancer. Its reliability can be reduced by inter-observer variability.
Angela Fischer Maranta, Simon Broder, Constanze Fritzsche, Michael Knauer, Beat Thürlimann, Wolfram Jochum, Thomas Ruhstaller   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Ki-67 as a prognostic marker according to breast cancer molecular subtype

Cancer Biology & Medicine, 2016
Objective: Ki-67 plays an important function in cell division, but its exact role is still unknown. Moreover, few works regarding its overall function were published.
Nahed A. Soliman, Shaimaa M. Yussif
doaj   +1 more source

Impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification [PDF]

, 2013
High expression levels of glucose transporter isoform 1 (GLUT1) and Ki-67 are reportedly associated with malignancy-related clinicopathological factors in malignant tumors. Recently, a new histological IASLC/ATS/ERS classification for lung adenocarcinoma
Asano, Brown, Cappuzzo, Carvalho, Colozza, Devesa, Dowsett, Ferlay, Furudoi, Goldhirsch, Goldhirsch, HIROAKI ASANO, HIROMASA YAMAMOTO, Ichihara, Jalava, Jemal, Jonat, Jun, JUNICHI SOH, Kalir, KAZUHIKO SHIEN, KAZUNORI TSUKUDA, Klintman, Koike, KOUICHI ICHIMURA, Koukourakis, MASASHI FURUKAWA, Mehdi, Minami, Noguchi, NORIMITSU TANAKA, Parente, Rami-Porta, Sasaki, Scholzen, SHINICHI TOYOOKA, SHINICHIRO MIYOSHI, Simony, Suehisa, TAKAYUKI MURAOKA, Tokumo, Toyooka, Travis, Travis, TSUYOSHI UENO, Tungekar, van Rens, Wang, Watanabe, Wood, Yamada, Yerushalmi, Yokose, Yoshida, YUHO MAKI, Yun   +55 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Biological subtyping of early breast cancer : a study comparing RT-qPCR with immunohistochemistry [PDF]

, 2016
The biological subtype of breast cancer influences the selection of systemic therapy. Distinction between luminal A and B cancers depends on consistent assessment of Ki-67, but substantial intra-observer and inter-observer variability exists when ...
Auvinen, Paivi, Eidt, Sebastian, Heikkila, Paivi, Isola, Jorma, Joensuu, Heikki, Jyrkkio, Sirkku, Kellokumpu-Lehtinen, Pirkko-Liisa, Laible, Mark, Lakis, Sotiris, Sahin, Ugur, Schlombs, Kornelia, Sihto, Harri, Turpeenniemi-Hujanen, Taina, Weber, Stefan, Wirtz, Ralph M.   +14 more
core   +2 more sources

Ki-67 in meningioma: distribution and implications

Journal of Neurosurgery
OBJECTIVE Ki-67 is a widely used marker of proliferation in meningiomas, influencing prognostic assessment and treatment decisions, including adjuvant radiation therapy. However, it is increasingly appreciated that some meningiomas are enriched with immune infiltration, which may confound Ki-67 interpretation as
Xiaopeng, Guo, Ruchit V, Patel, James A, Lederer, David M, Meredith, Wenya Linda, Bi   +4 more
openaire   +2 more sources

Analysis of human Ki-67 gene promoter and identification of the Sp1 binding sites for Ki-67 transcription

Tumor Biology, 2011
Ki-67 as a cell proliferation marker is tightly associated with maintenance and regulation of the cell division. To understand the mechanism of Ki-67 gene expression and regulation, we first cloned 5'-flanking region and identified the Ki-67 core promoter.
Dong-Sheng, Pei, Guo-Wei, Qian, Hui, Tian, Jie, Mou, Wang, Li, Jun-Nian, Zheng   +5 more
openaire   +2 more sources