Results 61 to 70 of about 233,700 (287)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study.

PLoS ONE, 2019
BACKGROUND:Ki-67 is known to be useful in estimating the fraction of proliferation tumor cells in various malignancies. We tried to investigate clinical association of Ki-67 (MIB-1) expression with the oncological outcomes in patients with localized ...
Seok-Soo Byun, Minseung Lee, Sung Kyu Hong, Hakmin Lee   +3 more
doaj   +1 more source

Prediction of the Ki-67 marker index in hepatocellular carcinoma based on Dynamic Contrast-Enhanced Ultrasonography with Sonazoid

Insights into Imaging, 2022
Background Ki-67 is widely used as a proliferative and prognostic factor in HCC. This study aimed to analyze the relationship between dynamic contrast-enhanced ultrasonography (DCE-US) parameters and Ki-67 expression.
Zhe Huang, PingPing Zhou, ShanShan Li, Kaiyan Li   +3 more
doaj   +1 more source

Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively [PDF]

, 2013
Soft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal tumors of >50 subtypes. However, STSs represent
ADHEMAR LONGATTO-FILHO, ALLINI MAFRA DA COSTA, Behar, Brown, Choong, Ch’ng, Ch’ng, CLEYTON ZANARDO DE OLIVEIRA, Conrotto, Conrotto, EMÍLIO CARLOS CURCELLI, Endl, Fletcher, FLÁVIA COLTRI EGUCHI, Gerdes, Goodman, GUILHERME GOMES RIBEIRO, Hall, Heslin, Hoos, Huutanen, Jensen, Jones, Kato, Kitsukawa, Kolodkin, Kumanogoh, Luo, MARCELO CAMPOS, MARCOS CEITA NUNES, Mizui, Ottaiano, Popiolek, Roche, Rody, SANDRA REGINA MORINI DA SILVA, Sekido, SILVANA GISELE PEGORIN DE CAMPOS, Taylor, Tessier-Lavigne, Ueda, VALTER PENNA   +41 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Exploratory analyses of the associations between Ki-67 expression, lymph node metastasis, and prognosis in patients with esophageal squamous cell cancer [PDF]

PeerJ
Background The relationships between Ki-67/MKI67 expression, lymph node metastasis (LNM), vascular invasion (VI), and perineural invasion (PI) in esophageal squamous cell cancer (ESCC) remain unclear.
Jianqing Zheng, Bifen Huang, Ying Chen, Bingwei Zeng, Lihua Xiao, Min Wu   +5 more
doaj   +2 more sources

p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya [PDF]

, 2015
Background: The identification of suited early detection tests is one among the multiple requirements to reduce cervical cancer incidence in developing countries.
Boga, Hamadi, Mbithi, John, Muigai, Anne, Reuschenbach, Miriam, Schmidt, Dietmar, von Knebel-Doeberitz, Magnus, Wangari Ngugi, Caroline, Wanyoro, Karanja, Wanzala, Peter   +8 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma [PDF]

, 2017
Statement of the Problem: Squamous cell carcinoma (SCC) is the most frequent oral cancer whose 5-year survival rate is 80% for early-detected lesions and nearly 30-50% for advanced lesions.
Andisheh-Tadbir, Azadeh., Ashraf, Mohammad Javad., Ebrahimi, Rahele., Khademi, Bijan., Rezazadeh, Fahimeh.   +4 more
core   +1 more source

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice [PDF]

, 2015
Helicobacter infection causes a chronic superficial gastritis that in some cases progresses via atrophic gastritis to adenocarcinoma. Proapoptotic bak has been shown to regulate radiation-induced apoptosis in the stomach and colon and also susceptibility
Abuderman, A A, Burkitt, M D, Duckworth, C A, O'Reilly, L A, Pritchard, D M, Williams, J M   +5 more
core   +2 more sources