Results 61 to 70 of about 1,258,688 (288)
Ki-67 and the Chromosome Periphery Compartment in Mitosis [PDF]
Trends in Cell Biology, 2017 The chromosome periphery is a complex network of proteins and RNA molecules (many derived from nucleoli) that covers the outer surface of chromosomes and whose function remains mysterious. Although it was first described over 130 years ago, technological advances and the recent discovery that Ki-67 acts as an organiser of this region have allowed the ...
Booth, Daniel G., Earnshaw, William C.
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Brain Sciences, 2022 Objective: The Ki-67 index is an indicator of the active proliferation and aggressive behavior of pituitary adenomas (PAs). Appropriate pre- and intra-operatives of the Ki-67 index can help surgeons develop better and more personalized treatment ...
Xuanzhi Wang +5 more
doaj +1 more source
Scientific Reports, 2020 This retrospective analysis evaluated the interaction between Ki-67 and histological grade and their prognostic role in different breast cancer subtypes.
Qingmo Liang +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Clinical and Translational Medicine, 2020 Background and Aim To develop and validate radiomic prediction models using contrast-enhanced computed tomography (CE-CT) to preoperatively predict Ki-67 expression in gastrointestinal stromal tumors (GISTs). Method A total of 339 GIST patients from four
Qing-Wei Zhang +8 more
semanticscholar +1 more source
Ki-67 expression in pulmonary tumors—reply [PDF]
Translational Lung Cancer Research, 2016 First of all, we would like to congratulate Professor Chirieac for his excellent discussion on proliferation assessment in lung tumors. Taken together, he concludes that assessment of proliferation is important for the prognosis of non-small cell lung cancer (NSCLC), prediction of brain metastases in patients with lung adenocarcinoma, and the diagnosis,
Mark, Kriegsmann, Arne, Warth
openaire +2 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Ki-67 as a prognostic marker according to breast cancer molecular subtype
Cancer Biology & Medicine, 2016 Objective: Ki-67 plays an important function in cell division, but its exact role is still unknown. Moreover, few works regarding its overall function were published.
Nahed A. Soliman, Shaimaa M. Yussif
doaj +1 more source