Results 121 to 130 of about 203,911 (336)

Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation

Advanced Functional Materials, EarlyView.
Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna, Katarina Gugujonovic, Manuela Schiek, Alessandro Bellapianta, Paul Werginz, Amelie Ziller, Markus Clark Scharber, Ahmad Salti, Matthias Bolz, Mihai Irimia‐Vladu, Günther Zeck   +10 more
wiley   +1 more source

Ki67 index in intrinsic breast cancer subtypes and its association with prognostic parameters

BMC Research Notes, 2019
Ki67 is the most commonly used marker to evaluate proliferative index in breast cancer, however no cutoff values have been clearly defined for high ki67 index.
A. Hashmi, K. Hashmi, M. Irfan, Saadia Mehmood Khan, Muhammad M. Edhi, J. Ali, S. Hashmi, Huda Asif, N. Faridi, Amir Khan   +9 more
semanticscholar   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

A prognostic prediction model for advanced gastric cancer based on Ki67

Zhongguo linchuang yanjiu
Objective To establish and validate a nomogram model for predicting the prognosis of advanced gastric cancer based on Ki67 expression，and to explore effect of different levels of Ki67 on progression free survival（PFS）in the same patient with different ...
NIU Linjun*，LI Xinzhong，LYU Yongjian
doaj   +1 more source

Loss of expression of claudin-1 in psoriasis is associated with proliferative state of keratinocytes

Indian Journal of Dermatopathology and Diagnostic Dermatology, 2020
Background: Psoriasis is a chronic remitting and relapsing inflammatory disease, with a prevalence of 0.44%–2.5% and is characterized by T-cell-mediated rapid turnover of epithelial cells.
Manoj Gopal Madakshira, Bishan Dass Radotra, Uma Nahar Saikia   +2 more
doaj   +1 more source

Ki67 and PR in Patients Treated with CDK4/6 Inhibitors: A Real-World Experience

Diagnostics, 2020
CDK4/6 inhibitors (CDK4/6i) are recommended in patients with estrogen receptor (ER)-positive, HER2-negative advanced breast cancer (ABC). Up to now, no prognostic biomarkers have been identified in this setting. We retrospectively analyzed the expression
M. Palleschi, R. Maltoni, S. Ravaioli, A. Vagheggini, F. Mannozzi, F. Fanini, F. Pirini, M. Tumedei, E. Barzotti, L. Cecconetto, S. Sarti, S. Manunta, P. Possanzini, A. Fedeli, A. Curcio, M. Altini, U. de Giorgi, A. Rocca, S. Bravaccini   +18 more
semanticscholar   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Identification Of Mitotically Competent SOX2+ Cells In White Matter Of Normal Human Adult Brain [PDF]

, 2011
SOX2 expression is linked to the undifferentiated state of stem cells in mammalian neurogenic niches. While its expression has been reported in the adult human subventricular zone (SVZ), to date it has not been detected in adult human white matter.
Angel Ayuso-Sacido, Antonio Gutierrez-Martin, Carmen Escobedo-Lucea, Jorge Oliver-De la Cruz, Jose Manuel Garcia-Verdugo, Josefa Carrion-Navarro   +5 more
core   +1 more source

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]

, 2016
mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat, Califano, Joseph A, Callejas-Valera, Juan Luis, Cohen, Ezra E, Gutkind, J Silvio, Iglesias-Bartolomé, Ramiro, Lippman, Scott M, Luo, Ji, Molinolo, Alfredo A, Wang, Zhiyong, Yamaguchi, Kosuke   +10 more
core   +1 more source

p53, ER, and Ki67 Expression in Canine Mammary Carcinomas and Correlation With Pathological Variables and Prognosis

Veterinary Pathology-Supplement, 2020
Using immunohistochemistry, 170 canine mammary carcinomas were evaluated for p53, ER (estrogen receptor), and Ki67. Of the 170 tumors, 89 were grade I (52.3%), 36 were grade II (21.2%), and 45 were grade III (26.4%).
B. Brunetti, B. Bacci, C. Angeli, C. Benazzi, L. V. Muscatello   +4 more
semanticscholar   +1 more source