Results 111 to 120 of about 177,505 (309)

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]

, 2018
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core   +1 more source

Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients [PDF]

, 2013
<br>Background:Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation by Cdk1 or ERK1/2 is of prognostic ...
BV Kallakury, C E Adams, C Tannahill, D Gioeli, D Gioeli, G Fyffe, GG Kuiper, H Y Leung, H Zong, HY Wong, J Edwards, J Ferlay, J M Willder, JC Obenauer, JS Diallo, K Shigemura, KS McCarty, LA Ponguta, LJ Blok, M A Underwood, M Mistry, M Roach, M Seywright, MS Cookson, NG Anderson, P Chymkowitch, P G Horgan, P McCall, R Mukherjee, RE Bakin, RK Tyagi, S Chen, S Chen, S J Heng, SM Powell, T Kirkegaard, T Ohta, WC Bell, Y Wen, Z Fu, ZX Zhou   +40 more
core   +1 more source

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation. [PDF]

, 2016
Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated.
Chang, Hong-Tai, Chang, Yu-Chang, Chen, Chi-Long, Ger, Luo-Ping, Hsiao, Michael, Huang, Ming-Shyan, Jan, Yi-Hua, Lai, Tsung-Ching, Lin, Tsung-Chieh, Lin, Yuan-Feng, Liu, Yu-Peng, Pan, Wen-An, Shyy, John Y-J, Su, Chia-Yi, Tsai, Ming-Daw, Wu, Pei-Yu, Yang, Chih-Jen, Yeh, Chi-Tai   +17 more
core   +2 more sources

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Serous Tubal Intraepithelial Lesion: A Precancerous Lesion - An Incidental Finding in Tubo-Ovarian Torsion

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Proliferative epithelial lesions in the fallopian tubes may be found incidentally during the microscopic examination of salpingectomy specimens. Recent evidence has clearly implicated the changes in the mucosa of the fimbrial end of the fallopian tube in
Saloni Bharadwaj, Shirish S. Chandanwale, Akshi Raj, Madhuri Singh   +3 more
doaj   +1 more source

Possible Association of CD68 Positive Macrophages with Some other Prognostic Factors (ki67, ER, PR, Her2 neu) in Primary Breast Cancer and Axillary Lymph Node Metastasis [PDF]

Journal of Kerman University of Medical Sciences, 2017
Background: Breast cancer is formed of a neoplastic component (epithelial) and a non-neoplastic component (stroma). Stromal- stromal and tumor- stromal interactions have been shown in the regulation of cancer cell growth, metastatic capacity and outcome ...
Hakime Khalili, Shahriar Dabiri, Bahram Pourseyedi, Hamid Zeinalinejad   +3 more
doaj  

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer [PDF]

, 2017
Background and aims: Docetaxel (DTX) modestly increases patient survival of metastatic castration-resistant prostate cancer (mCRPC) due to insurgence of pharmacological resistance. Deregulation of Chromosome Region Maintenance (CRM-1)/ exportin-1 (XPO-1)-
Argueta, Christian, BIORDI, ASSUNTA LEDA, Biordi, Leda Assunta, Colapietro, Alessandro, Festuccia, Claudio, Flati, Vincenzo, Gravina, Giovanni Luca, Iorio, Roberto, Kauffman, Michael, Landesman, Yosef, Mancini, Andrea, Marampon, Francesco, Pompili, Simona, Sferra, Roberta, Shacham, Sharon   +14 more
core   +2 more sources

Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids

Advanced Materials, EarlyView.
Zonated osteochondral assembloid implants are engineered through scaffold‐free spatial assembly of induced pluripotent stem cell (iPSC)‐derived chondrocyte organoids and periosteum‐derived osteogenic organoids. Implanted into full‐thickness rat osteochondral defects, they promote hyaline‐like cartilage repair, support subchondral bone formation with ...
Liuqi Peng, Isaak Decoene, Hanna Svitina, Ioannis Papantoniou   +3 more
wiley   +1 more source