Results 141 to 150 of about 203,911 (336)

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients

Radiology and Oncology, 2016
Neuroendocrine markers, which could indicate for aggressive variants of prostate cancer and Ki67 (a well-known marker in oncology for defining tumor proliferation), have already been associated with clinical outcome in prostate cancer.
Pascale Mariarosa, Aversa Cinzia, Barbazza Renzo, Marongiu Barbara, Siracusano Salvatore, Stoffel Flavio, Sulfaro Sando, Roggero Enrico, Bonin Serena, Stanta Giorgio   +9 more
doaj   +1 more source

Human breast milk stem cells: a new challenge for perinatologists

Journal of Pediatric and Neonatal Individualized Medicine, 2016
The lactating mammary gland contains a stem cells population with multilineage potentialities. Recently it was also shown that breast milk contains a heterogeneous population of stem cells that have the potential to differentiate in vitro, under the ...
Giuseppina Pichiri, Daniele Lanzano, Monica Piras, Angelica Dessì, Alessandra Reali, Melania Puddu, Antonio Noto, Vassilios Fanos, Carlo Coni, Gavino Faa, Pierpaolo Coni   +10 more
doaj   +1 more source

The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling [PDF]

, 2015
The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal
ADAMO, Sergio, C. S. Mosteiro, D. l. Beiroa, F. F. Casanueva, I. Santos Zas, J. E. Viñuela, J. González Sánchez, J. M. Renaud, J. P. Camiña, J. Señarís, MORESI, Viviana, R. Gallego, R. Nogueiras, T. García Caballero, U. Gurriarán Rodríguez, W. Lin, Y. Pazos   +16 more
core   +1 more source

Analytical validation of a standardised scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicentre collaboration

Histopathology, 2019
The nuclear proliferation marker Ki67 assayed by immunohistochemistry has multiple potential uses in breast cancer, but an unacceptable level of interlaboratory variability has hampered its clinical utility.
S. Leung, T. Nielsen, L. Zabaglo, I. Arun, S. Badve, A. Bane, J. Bartlett, S. Borgquist, Martin C. Chang, A. Dodson, A. Ehinger, S. Fineberg, C. Focke, D. Gao, A. Gown, C. Gutierrez, J. Hugh, Z. Kos, A. Lænkholm, M. Mastropasqua, T. Moriya, S. Nofech-Mozes, C. Osborne, F. Penault-Llorca, T. Piper, T. Sakatani, R. Salgado, J. Starczynski, T. Sugie, B. Vegt, G. Viale, D. Hayes, L. McShane, M. Dowsett   +33 more
semanticscholar   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

De-escalated therapy for HR+/HER2+ breast cancer patients with Ki67 response after 2-week letrozole: results of the PerELISA neoadjuvant study

Annals of Oncology, 2019
Background In human epidermal growth factor receptor 2 (HER2+) breast cancers, neoadjuvant trials of chemotherapy plus anti-HER2 treatment consistently showed lower pathologic complete response (pCR) rates in hormone receptor (HR) positive versus ...
V. Guarneri, M. Dieci, G. Bisagni, A. Frassoldati, Giulia Valeria Bianchi, G. L. D. Salvo, E. Orvieto, L. Urso, T. Pascual, L. Paré, P. Galván, M. Ambroggi, C. A. Giorgi, G. Moretti, G. Griguolo, R. Vicini, A. Prat, Pierfranco Conte   +17 more
semanticscholar   +1 more source

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Immunohistochemical Changes of Polycystic Ovaries in rats Treated with Asparagus Officinalis L. Roots Extract

Medical Journal of Babylon
Background:Polycystic ovary syndrome (PCOS) which a series reproductive, metabolic and psychological condition that is characterized by abnormal gonadotropin secretion or hyperandrogenism and associated with insulin resistance and most commonly found in ...
Farah Jawad Al-masoudi, Ashwaq Kadhem Obeid   +1 more
doaj   +1 more source