Results 31 to 40 of about 1,736 (146)

Identification and Characterization of Novel Rat Polyomavirus 2 in a Colony of X-SCID Rats by P-PIT assay

mSphere, 2016
Polyomaviruses (PyVs) are known to infect a wide range of vertebrates and invertebrates and are associated with a broad spectrum of diseases, including cancers, particularly in immune-suppressed hosts. A novel polyomavirus, designated rat polyomavirus 2 (
Lora H. Rigatti, Tuna Toptan, Joseph T. Newsome, Patrick S. Moore, Yuan Chang   +4 more
doaj   +1 more source

High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij, Vito Pol, Jin Gan, Bjorn R. van Doodewaerd, Aysegul Sapmaz, Marta Campos Alonso, Günter Fritz, Klaus‐Peter Knobeloch, Paul P. Geurink   +8 more
wiley   +2 more sources

WU Polyomavirus in Children with Acute Lower Respiratory Tract Infections, South Korea

Emerging Infectious Diseases, 2007
In South Korea, WU polyomavirus (WUPyV) was detected in 34 (7%) of 486 children with acute lower respiratory tract infections, 3 (4.2%) of 72 asymptomatic children, and as coinfection with other respiratory viruses in 23 (67.6%) children.
Tae Hee Han, Ju-Young Chung, Ja Wook Koo, Sang Woo Kim, Eung-Soo Hwang   +4 more
doaj   +1 more source

Role of Human Polyomaviruses in Respiratory Tract Disease in Young Children

Emerging Infectious Diseases, 2008
KI virus was detected in respiratory secretions of 8/367 (2.2%) symptomatic and 0/96 asymptomatic children (p = 0.215). WU virus was detected in 26/367 (7.1%) symptomatic and 6/96 (6.3%) asymptomatic children (p = 1.00).
Rachel L. Wattier, Marietta Vázquez, Carla Weibel, Eugene D. Shapiro, David Ferguson, Marie L. Landry, Jeffrey S. Kahn   +6 more
doaj   +1 more source

No Evidence of Human Polyomavirus 9, WU and KI DNA in Kidney and Urinary Bladder Tumour Tissue Samples [PDF]

Pathobiology, 2016
<b><i>Background/Aims:</i></b> The oncogenic potential of human polyomaviruses (HPyVs) has been proposed, but so far only Merkel cell carcinoma polyomavirus seems to be associated with a human tumour. The role of BK polyomavirus (BKPyV) in human tumourigenesis remains controversial.
Eszter, Csoma, László, Bidiga, Gábor, Méhes, Lajos, Gergely   +3 more
openaire   +2 more sources

The polyomaviruses WUPyV and KIPyV: a retrospective quantitative analysis in patients undergoing hematopoietic stem cell transplantation

Virology Journal, 2012
Background The polyomaviruses WUPyV and KIPyV have been detected in various sample types including feces indicating pathogenicity in the gastrointestinal (GI) system.
Motamedi Nasim, Mairhofer Helga, Nitschko Hans, Jäger Gundula, Koszinowski Ulrich H   +4 more
doaj   +1 more source

Role of BK Virus CTLs in the Treatment of BK Virus–Associated Nephropathy in Kidney‐Transplant and Hematopoietic Cell Transplant Recipients

Transplant Infectious Disease, Volume 28, Issue 2, March/April 2026.
Third‐party, BK virus‐specific cytotoxic T lymphocytes (CTLs) were safe and effective in reducing viremia in kidney and stem cell transplant recipients with BK virus nephropathy. However, they did not improve kidney function. Earlier administration may be more beneficial before nephropathy and irreversible damage occur.
Amanda Olson, Ye Ethan Li, Rafet Basar, Pinaki Banerjee, Indresh Kaur, Glorette Abueg, Melihate Sylejmani, Nadima Uprety, Rejeena Shrestha, Francia Reyes Silva, Valda Page, Richard E. Champlin, Dimitrios P. Kontoyiannis, Roy F. Chemaly, Elizabeth J. Shpall, Linda Moore, Osama A. Gaber, Katayoun Rezvani, Ala Abudayyeh   +18 more
wiley   +1 more source

Clinical, Pathological, and Imaging Study of Pilomatrixoma: A Retrospective Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims A retrospective analysis was conducted on the clinical, pathological, and imaging features of 471 cases of pilomatrixoma, aiming to enhance clinicians' understanding of pilomatrixoma. Methods A total of 471 cases of pilomatrixoma diagnosed and surgically treated in the Affiliated Hospital of Southwest Medical University ...
Qi Hao, Cong‐Gai Huang, Chao‐Ying Wu, Rong Kuang, Meng‐Ze Li   +4 more
wiley   +1 more source

A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children

Journal of Clinical Virology, 2007
Recently, Allander and co-workers reported the discovery of a new human polyomavirus, KI virus, in respiratory secretions from patients with acute respiratory tract infection (ARTI).We examined 951 respiratory samples collected in Queensland, Australia, between November 2002 and August 2003 from patients with respiratory infection, for the presence of ...
Bialasiewicz, Seweryn, Whiley, David M., Lambert, Stephen B., Wang, David, Nissen, Michael D., Sloots, Theo P.   +5 more
openaire   +5 more sources

Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
In vitro breast cancer models that closely mimic the complex biological and cellular interactions within the tumor microenvironment hold strong promise for enhancing our understanding of tumor progression, immune system behavior, and resistance to therapies, which are essential for developing personalized cancer treatments. Abstract Engineered in vitro
Wonwoo Jeong, Sang Jin Lee
wiley   +1 more source