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Kidney cancer [PDF]

open access: yesUrologic Oncology: Seminars and Original Investigations, 2012
Over 65,000 Americans are diagnosed with kidney cancer each year and nearly 13,000 die of this disease. Kidney cancer is not a single disease, it is made up of a number of different types of cancer, each with a different histology, a different clinical course, responding differently to therapy and caused by a different gene. Study of the thirteen genes
W Marston, Linehan, W Kimryn, Rathmell
openaire   +2 more sources

Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis

open access: yesPLoS ONE, 2016
Chronic kidney disease (CKD) is a global health burden with a high economic cost to health systems and is an independent risk factor for cardiovascular disease (CVD).
N. Hill   +6 more
semanticscholar   +1 more source

Kidney fibrosis: from mechanisms to therapeutic medicines

open access: yesSignal Transduction and Targeted Therapy, 2023
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a hallmark manifestation in different progressive CKD; However, at ...
Rong-shuang Huang, P. Fu, Liang Ma
semanticscholar   +1 more source

Diabetes and kidney cancer: A direct or indirect association? [PDF]

open access: yes, 2010
A positive association between diabetes and kidney cancer has been reported in several investigations, but it is unclear whether diabetes or its complications account for this association.
Bahij S. Nuwayhid   +4 more
core   +2 more sources

Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury

open access: yesCritical Care, 2007
IntroductionAcute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Having a uniform standard for diagnosing and classifying AKI would enhance our ability to manage these patients.
R. Mehta   +6 more
semanticscholar   +1 more source

Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases

open access: yesRenal Failure, 2018
Background: Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells ...
Yuanyuan Li   +10 more
doaj   +1 more source

The significance of serum levels of soluble interleukin-2 receptor in patients undergoing maintenance hemodialysis

open access: yesRenal Failure, 2020
Background Elevated serum levels of sIL-2R are commonly observed in patients undergoing maintenance hemodialysis (MHD). However, the clinical implications in these subjects are unclear.
Xiaohong Chen   +8 more
doaj   +1 more source

Regulated cell death pathways in kidney disease

open access: yesNature Reviews Nephrology, 2023
Regulated cell death through either apoptosis or necrosis contributes to parenchymal cell loss in acute and chronic kidney disease and may also modulate inflammation, fibrosis and the immune response.
A. Sanz   +3 more
semanticscholar   +1 more source

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. [PDF]

open access: yes, 2019
Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease. Group 2 innate lymphoid cells (ILC2s) are innate producers of type-2 cytokines and are critical regulators of homeostasis in ...
Cameron, Guy JM   +9 more
core   +4 more sources

Diabetic microangiopathy in Type 1 (insulin-dependent) diabetic patients after successful pancreatic and kidney or solitary kidney transplantation [PDF]

open access: yes, 1991
To evaluate the beneficial effect of pancreatic grafting on peripheral microcirculation and long-term clinical outcome, we compared data of 28 Type 1 (insulin-dependent) diabetic patients either given a pancreatic and kidney graft simultaneously or given
Abendroth, D.   +4 more
core   +1 more source

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