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Kidney cancer [PDF]

Urologic Oncology: Seminars and Original Investigations, 2012
Over 65,000 Americans are diagnosed with kidney cancer each year and nearly 13,000 die of this disease. Kidney cancer is not a single disease, it is made up of a number of different types of cancer, each with a different histology, a different clinical course, responding differently to therapy and caused by a different gene. Study of the thirteen genes
W Marston, Linehan, W Kimryn, Rathmell
  +6 more sources

From kidney injury to kidney cancer [PDF]

Kidney International, 2021
Epidemiologic studies document strong associations between acute or chronic kidney injury and kidney tumors. However, whether these associations are linked by causation, and in which direction, is unclear. Accumulating data from basic and clinical research now shed light on this issue and prompt us to propose a new pathophysiological concept with ...
Peired A. J., Lazzeri E., Guzzi F., Anders H. -J., Romagnani P.   +4 more
openaire   +2 more sources

Kidney Cancer [PDF]

The Cancer Journal, 2016
The number of new cases of renal cell carcinoma has been steadily increasing since the 1960s, reaching 62,000 and 89,000 annually in the United States and Europe, respectively, in 2016. The current standard of care for early-stage disease is nephron-sparing surgery, which has a demonstrated long-term disease-free survival and an acceptable safety ...
S Brandon, Hancock, Christos S, Georgiades   +1 more
  +5 more sources

Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma

Advances in Radiation Oncology, 2021
Purpose: Oligoprogression, defined as limited sites of progression on systemic therapy, in patients with metastatic renal cell carcinoma (mRCC) is not uncommon, possibly because of inter- and intratumoral heterogeneity.
Jonathan E. Schoenhals, BS, Osama Mohamad, MD, PhD, Alana Christie, MS, Yuanyuan Zhang, MD, PhD, Daniel Li, MD, Nirmish Singla, MD, MSCS, Isaac Bowman, MD, Waddah Arafat, MD, Hans Hammers, MD, Kevin Courtney, MD, PhD, Suzanne Cole, MD, Aditya Bagrodia, MD, Vitaly Margulis, MD, Neil Desai, MD, Aurelie Garant, MD, Hak Choy, MD, Robert Timmerman, MD, James Brugarolas, MD, PhD, Raquibul Hannan, MD, PhD   +18 more
doaj   +1 more source

Patient-reported Experience of Diagnosis, Management, and Burden of Renal Cell Carcinomas: Results from a Global Patient Survey in 43 Countries

European Urology Open Science, 2022
The International Kidney Cancer Coalition (IKCC) is a federation of 46 affiliated patient organisations representing 1.2 million patients worldwide that is committed to reducing the global burden of kidney cancer.
Rachel Giles, Deborah Maskens, Robert Bick, Robin Martinez, Malcolm Packer, Daniel Heng, James Larkin, Axel Bex, Michael Jewett, Eric Jonasch, Sara MacLennan   +10 more
doaj   +1 more source

Determinants of renal cell carcinoma invasion and metastatic competence

Nature Communications, 2021
Tumour thrombi (TT) are intravascular extensions of renal cell carcinomas (RCC) which often lead to distant metastases. Here the authors examine the determinants of vascular invasion and metastasis in a unique cohort of RCC patients with TT using multi ...
Kangsan Kim, Qinbo Zhou, Alana Christie, Christina Stevens, Yuanqing Ma, Oreoluwa Onabolu, Suneetha Chintalapati, Tiffani Mckenzie, Vanina Toffessi Tcheuyap, Layton Woolford, He Zhang, Nirmish Singla, Pravat Kumar Parida, Mauricio Marquez-Palencia, Ivan Pedrosa, Vitaly Margulis, Arthur Sagalowsky, Zhiqun Xie, Tao Wang, Steffen Durinck, Zora Modrusan, Somasekar Seshagiri, Payal Kapur, James Brugarolas, Srinivas Malladi   +24 more
doaj   +1 more source

Kidney cancer

Radiology and Oncology, 2007
We quantified the burden of kidney cancer in the United States by identifying trends in the use of health care resources and estimating the economic impact of the disease.The analytical methods used to generate these results were described previously.The incidence of all stages of kidney cancer is increasing in America, particularly T1 disease.
Eric M, Wallen, Raj S, Pruthi, Geoffrey F, Joyce, Matthew, Wise   +3 more
openaire   +5 more sources

Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures

Kidney International Reports, 2022
Introduction: Individuals with focal segmental glomerular sclerosis (FSGS) typically undergo kidney biopsy only once, which limits the ability to characterize kidney cell gene expression over time.
Khun Zaw Latt, Jurgen Heymann, Joseph H. Jessee, Avi Z. Rosenberg, Celine C. Berthier, Arnon Arazi, Sean Eddy, Teruhiko Yoshida, Yongmei Zhao, Vicky Chen, George W. Nelson, Margaret Cam, Parimal Kumar, Monika Mehta, Michael C. Kelly, Matthias Kretzler, Patricio E. Ray, Marva Moxey-Mims, Gregory H. Gorman, Brent L. Lechner, Renu Regunathan-Shenk, Dominic S. Raj, Katalin Susztak, Cheryl A. Winkler, Jeffrey B. Kopp   +24 more
doaj   +1 more source

β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity

Nature Communications, 2021
During insulin-resistance, the compensatory expansion of beta-cell mass is able to delay or the onset of overt type 2 diabetes. Here, the authors report that beta-arrestin-1, an intracellular protein known to regulate signalling through G protein-coupled
Luiz F. Barella, Mario Rossi, Sai P. Pydi, Jaroslawna Meister, Shanu Jain, Yinghong Cui, Oksana Gavrilova, Gianluca Fulgenzi, Lino Tessarollo, Jürgen Wess   +9 more
doaj   +1 more source

Comparative risk of acute kidney injury among cancer patients treated with immune checkpoint inhibitors

Cancer Communications, 2023
With the development and introduction of immune checkpoint inhibitors (ICIs) in cancer patients, immune‐related side effects have increasingly attracted attention. However, the risks of immune‐related renal toxicity are poorly characterized.
Fei Liu, Zixian Wang, Xiaofan Li, Zhen Zhang, Yue Yang, Junquan Chen, Dinghua Chen, Lingling Wu, Xiangyu Liu, Sujun Han, Fangming Wang, Wasilijiang Wahafu, Yibo Gao, Shancheng Ren, Nianzeng Xing, Guangyan Cai, Xiangmei Chen   +16 more
doaj   +1 more source