Results 41 to 50 of about 1,036,066 (335)

Staging CT chest for cT1a renal masses: Does it change management?

BJUI Compass
Objectives Baseline staging investigations for renal masses invariably include a CT of the chest. However, EAU guidelines have given a weak recommendation that CT chest can be omitted in incidental T1a tumours (≤4 cm) without systemic symptoms, due to ...
Sanjana Ilangovan, Hannah Warren, Federica Sordelli, Thet Paing Oo, Pyae Phyo Tun, Prasad Patki, Faiz Mumtaz, Ravi Barod, Axel Bex, Maxine Tran   +9 more
doaj   +1 more source

Is Partial Nephrectomy A Primary Option for Patients with T1b Renal Cell Carcinoma—A National Population-Based Study

Urology Research and Practice
Objective: Renal cell carcinoma (RCC) patients in clinical T1 RCC generally exhibit a favorable prognosis. Guidelines recommend partial nephrectomy (PN), also for cT1b RCCs.
Sven Lundstam, Tarik Almdalal, Andreas Karlsson Rosenblad, Börje Ljungberg, National Swedish Kidney Cancer Register Steering Committee   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Neuropeptide G Protein-Coupled Receptors as Oncotargets

Frontiers in Endocrinology, 2018
Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they
Terry W. Moody, Irene Ramos-Alvarez, Robert T. Jensen   +2 more
doaj   +1 more source

Co-creating with patients an impact framework across the medicine’s life cycle: a qualitative study exploring patients’ experiences of involvement in and perceptions of impact measures

Research Involvement and Engagement, 2022
Plain English summary Developing medicines involves multiple stages, all essential for pharmaceutical companies. However, this approach is becoming increasingly costly and patients are rarely involved in defining treatment outcomes.
Oleks Gorbenko, Pascale Cavillon, Rachel H. Giles, Teodora Kolarova, Muriël Marks, Antonella Cardone, Sandeep Bagga, Claire Nolan   +7 more
doaj   +1 more source

ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM [PDF]

, 2016
The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α,
Fletcher, Eliot S, Fletcher, Eliot S
core   +1 more source

Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma [PDF]

, 2015
We thank Professors Michael Rehli, Yoshiaki Ito, and Kristian Helin for gifting plasmids, Dr. Alasdair MacKenzie (University of Aberdeen) for helpful discussion, and Mr. Takashi Mizukami, Ms. Ryoko Tokuda, and Ms.
Mizokami, Atsushi, Nakamoto, Masaru, Nakamura, Ritsuko, Namiki, Mikio, Ooi, Akishi, Oyama, Takeru, Tajiri, Ryosuke   +6 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

UroPredict: Machine learning model on real-world data for prediction of kidney cancer recurrence (UroCCR-120)

npj Precision Oncology
Renal cell carcinoma (RCC) is most often diagnosed at a localized stage, where surgery is the standard of care. Existing prognostic scores provide moderate predictive performance, leading to challenges in establishing follow-up recommendations after ...
Gaëlle Margue, Loïc Ferrer, Guillaume Etchepare, Pierre Bigot, Karim Bensalah, Arnaud Mejean, Morgan Roupret, Nicolas Doumerc, Alexandre Ingels, Romain Boissier, Géraldine Pignot, Bastien Parier, Philippe Paparel, Thibaut Waeckel, Thierry Colin, Jean-Christophe Bernhard   +15 more
doaj   +1 more source

The Efficacy and Safety of Tyrosine Kinase Inhibitors for Von Hippel–Lindau Disease: A Retrospective Study of 32 Patients

Frontiers in Oncology, 2019
Background: Von Hippel-Lindau (VHL) disease is an autosomal-dominant hereditary cancer syndrome. Currently, studies on tyrosine kinase inhibitor (TKI) therapy for VHL disease are scarce. In this study, we retrospectively evaluated the efficacy and safety
Kaifang Ma, Kaifang Ma, Kaifang Ma, Kaifang Ma, Baoan Hong, Baoan Hong, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Yanqing Gong, Yanqing Gong, Yanqing Gong, Yanqing Gong, Jiangyi Wang, Shengjie Liu, Xiang Peng, Bowen Zhou, Bowen Zhou, Bowen Zhou, Bowen Zhou, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Haibiao Xie, Haibiao Xie, Haibiao Xie, Haibiao Xie, Kenan Zhang, Kenan Zhang, Kenan Zhang, Kenan Zhang, Lei Li, Lei Li, Lei Li, Lei Li, Desheng Cai, Desheng Cai, Desheng Cai, Desheng Cai, Zixin Wang, Zixin Wang, Zixin Wang, Zixin Wang, Lin Cai, Lin Cai, Lin Cai, Lin Cai, Kan Gong, Kan Gong, Kan Gong, Kan Gong   +52 more
doaj   +1 more source