Results 51 to 60 of about 1,031,295 (331)

The Efficacy and Safety of Tyrosine Kinase Inhibitors for Von Hippel–Lindau Disease: A Retrospective Study of 32 Patients

Frontiers in Oncology, 2019
Background: Von Hippel-Lindau (VHL) disease is an autosomal-dominant hereditary cancer syndrome. Currently, studies on tyrosine kinase inhibitor (TKI) therapy for VHL disease are scarce. In this study, we retrospectively evaluated the efficacy and safety
Kaifang Ma, Kaifang Ma, Kaifang Ma, Kaifang Ma, Baoan Hong, Baoan Hong, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Yanqing Gong, Yanqing Gong, Yanqing Gong, Yanqing Gong, Jiangyi Wang, Shengjie Liu, Xiang Peng, Bowen Zhou, Bowen Zhou, Bowen Zhou, Bowen Zhou, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Haibiao Xie, Haibiao Xie, Haibiao Xie, Haibiao Xie, Kenan Zhang, Kenan Zhang, Kenan Zhang, Kenan Zhang, Lei Li, Lei Li, Lei Li, Lei Li, Desheng Cai, Desheng Cai, Desheng Cai, Desheng Cai, Zixin Wang, Zixin Wang, Zixin Wang, Zixin Wang, Lin Cai, Lin Cai, Lin Cai, Lin Cai, Kan Gong, Kan Gong, Kan Gong, Kan Gong   +52 more
doaj   +1 more source

Association of CDH1 Germline Variants and Colon Polyp Phenotypes in Patients With Hereditary Diffuse Gastric Cancer

Gastro Hep Advances, 2023
Background and Aims: Germline CDH1 variants resulting in E-cadherin loss of function result in an increased risk of diffuse type gastric cancer and lobular type breast cancer.
Monica Passi, Lauren A. Gamble, Sarah G. Samaranayake, Samuel A. Schueler, Bryan F. Curtin, Grace-Ann Fasaye, Cassidy Bowden, Sandeep Gurram, Martha Quezado, Markku Miettinen, Christopher Koh, Theo Heller, Jeremy L. Davis   +12 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Ontological analyses reveal clinically-significant clear cell renal cell carcinoma subtypes with convergent evolutionary trajectories into an aggressive typeResearch in context

EBioMedicine, 2020
Background: Clear cell renal cell carcinoma (ccRCC) is a particularly challenging tumor type because of its extensive phenotypic variability as well as intra-tumoral heterogeneity (ITH).
Qi Cai, Alana Christie, Satwik Rajaram, Qinbo Zhou, Ellen Araj, Suneetha Chintalapati, Jeffrey Cadeddu, Vitaly Margulis, Ivan Pedrosa, Dinesh Rakheja, Renee M. McKay, James Brugarolas, Payal Kapur   +12 more
doaj   +1 more source

Efficacy and safety of Androgen Deprivation Therapy (ADT) combined with modified docetaxel chemotherapy versus ADT combined with standard docetaxel chemotherapy in patients with metastatic castration-resistant prostate cancer: study protocol for a multicentre prospective randomized controlled trial

BMC Cancer, 2022
Background Androgen deprivation therapy (ADT) combined with docetaxel chemotherapy is the standard treatment for metastatic castration-resistant prostate cancer (mCRPC) patients.
Xiangwei Yang, Hong Chen, Duanya Xu, Xianju Chen, Yamei Li, Jun Tian, Dongwen Wang, Jun Pang   +7 more
doaj   +1 more source

A rare cause of recurrent spontaneous pneumothorax: Birt-hogg-dube syndrome [PDF]

, 2018
Birt-Hogg-Dube (BHD) syndrome is an unusual disorder characterized by the triad of cutaneous lesions, renal tumors and lung cysts. In cases with BHD syndrome, the frequency of recurrent pneumothorax is increased due to presence of multiple lung cysts. It
Demirci, M., Karaman, Engin, Ufuk, F., Yavaş, H.G.   +3 more
core   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Metabolomic landscape of renal cell carcinoma in von Hippel-Lindau syndrome in a Chinese cohort

iScience
Summary: Von Hippel-Lindau (VHL) syndrome is a rare autosomal dominant disorder, where renal cell carcinoma (RCC) serves as a significant cause of mortality. We collected peripheral blood from 61 VHL-RCC patients and 31 healthy individuals, along with 19
Zedan Zhang, Yi Wang, Wuping Yang, Tao Liu, Chuandong Wang, Cong Huang, Yawei Xu, Xiaolin Chen, Jingcheng Zhou, Yizhou Wang, Xiaohua Zhou, Yanqing Gong, Kan Gong   +12 more
doaj   +1 more source

Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells

Cell Reports, 2016
Nephron progenitors in the embryonic kidney propagate while generating differentiated nephrons. However, in mice, the progenitors terminally differentiate shortly after birth.
Shunsuke Tanigawa, Atsuhiro Taguchi, Nirmala Sharma, Alan O. Perantoni, Ryuichi Nishinakamura   +4 more
doaj   +1 more source

Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine

Nature Communications, 2023
Somatostatin receptor 2 (SSTR2) represents a therapeutic target of neuroendocrine tumors. Here, authors report two structures of SSTR2 bound to peptide octreotide and small molecule paltusotine, revealing the basis subtype selectivity and signal bias ...
Jie Zhao, Hong Fu, Jingjing Yu, Weiqi Hong, Xiaowen Tian, Jieyu Qi, Suyue Sun, Chang Zhao, Chao Wu, Zheng Xu, Lin Cheng, Renjie Chai, Wei Yan, Xiawei Wei, Zhenhua Shao   +14 more
doaj   +1 more source