Results 51 to 60 of about 921,567 (386)

Co-creating with patients an impact framework across the medicine’s life cycle: a qualitative study exploring patients’ experiences of involvement in and perceptions of impact measures

Research Involvement and Engagement, 2022
Plain English summary Developing medicines involves multiple stages, all essential for pharmaceutical companies. However, this approach is becoming increasingly costly and patients are rarely involved in defining treatment outcomes.
Oleks Gorbenko, Pascale Cavillon, Rachel H. Giles, Teodora Kolarova, Muriël Marks, Antonella Cardone, Sandeep Bagga, Claire Nolan   +7 more
doaj   +1 more source

Kidney and Kidney Tumor Segmentation using a Logical Ensemble of U-nets with Volumetric Validation [PDF]

, 2019
Automated medical image segmentation is a priority research area for computational methods. In particular, detection of cancerous tumors represents a current challenge in this area with potential for real-world impact. This paper describes a method developed in response to the 2019 Kidney Tumor Segmentation Challenge (KiTS19). Axial computed tomography
arxiv   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Is Partial Nephrectomy A Primary Option for Patients with T1b Renal Cell Carcinoma—A National Population-Based Study

Urology Research and Practice
Objective: Renal cell carcinoma (RCC) patients in clinical T1 RCC generally exhibit a favorable prognosis. Guidelines recommend partial nephrectomy (PN), also for cT1b RCCs.
Sven Lundstam, Tarik Almdalal, Andreas Karlsson Rosenblad, Börje Ljungberg, National Swedish Kidney Cancer Register Steering Committee   +4 more
doaj   +1 more source

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. [PDF]

, 2019
p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function. However, the identity of reader protein(s) for p53 acetylation remains elusive. PBRM1, the second most highly mutated tumor suppressor gene in kidney cancer,
Cai, Weijia, Dulaimi, Essel, Jiang, Wei, Langbein, Lauren, Liao, Lili, Liu, Zongzhi Z, Su, Liya, Testa, Joseph R, Uzzo, Robert G, Yan, Qin, Yang, Haifeng, Zhang, Qing, Zhong, Zhijiu   +12 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine

Nature Communications, 2023
Somatostatin receptor 2 (SSTR2) represents a therapeutic target of neuroendocrine tumors. Here, authors report two structures of SSTR2 bound to peptide octreotide and small molecule paltusotine, revealing the basis subtype selectivity and signal bias ...
Jie Zhao, Hong Fu, Jingjing Yu, Weiqi Hong, Xiaowen Tian, Jieyu Qi, Suyue Sun, Chang Zhao, Chao Wu, Zheng Xu, Lin Cheng, Renjie Chai, Wei Yan, Xiawei Wei, Zhenhua Shao   +14 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

UroPredict: Machine learning model on real-world data for prediction of kidney cancer recurrence (UroCCR-120)

npj Precision Oncology
Renal cell carcinoma (RCC) is most often diagnosed at a localized stage, where surgery is the standard of care. Existing prognostic scores provide moderate predictive performance, leading to challenges in establishing follow-up recommendations after ...
Gaëlle Margue, Loïc Ferrer, Guillaume Etchepare, Pierre Bigot, Karim Bensalah, Arnaud Mejean, Morgan Roupret, Nicolas Doumerc, Alexandre Ingels, Romain Boissier, Géraldine Pignot, Bastien Parier, Philippe Paparel, Thibaut Waeckel, Thierry Colin, Jean-Christophe Bernhard   +15 more
doaj   +1 more source

The Efficacy and Safety of Tyrosine Kinase Inhibitors for Von Hippel–Lindau Disease: A Retrospective Study of 32 Patients

Frontiers in Oncology, 2019
Background: Von Hippel-Lindau (VHL) disease is an autosomal-dominant hereditary cancer syndrome. Currently, studies on tyrosine kinase inhibitor (TKI) therapy for VHL disease are scarce. In this study, we retrospectively evaluated the efficacy and safety
Kaifang Ma, Kaifang Ma, Kaifang Ma, Kaifang Ma, Baoan Hong, Baoan Hong, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Yanqing Gong, Yanqing Gong, Yanqing Gong, Yanqing Gong, Jiangyi Wang, Shengjie Liu, Xiang Peng, Bowen Zhou, Bowen Zhou, Bowen Zhou, Bowen Zhou, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Haibiao Xie, Haibiao Xie, Haibiao Xie, Haibiao Xie, Kenan Zhang, Kenan Zhang, Kenan Zhang, Kenan Zhang, Lei Li, Lei Li, Lei Li, Lei Li, Desheng Cai, Desheng Cai, Desheng Cai, Desheng Cai, Zixin Wang, Zixin Wang, Zixin Wang, Zixin Wang, Lin Cai, Lin Cai, Lin Cai, Lin Cai, Kan Gong, Kan Gong, Kan Gong, Kan Gong   +52 more
doaj   +1 more source