Results 101 to 110 of about 2,119,577 (353)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Relation between Blood Pressure Management and Renal Effects of Sodium-Glucose Cotransporter 2 Inhibitors in Diabetic Patients with Chronic Kidney Disease

Journal of Diabetes Research, 2019
Aim. The renoprotective effect of sodium-glucose cotransporter 2 inhibitors is thought to be due, at least in part, to a decrease in blood pressure.
Kazuo Kobayashi, Masao Toyoda, Noriko Kaneyama, Nobuo Hatori, Takayuki Furuki, Hiroyuki Sakai, Masahiro Takihata, Tomoya Umezono, Shun Ito, Daisuke Suzuki, Hiroshi Takeda, Akira Kanamori, Hisakazu Degawa, Hareaki Yamamoto, Hideo Machimura, Atsuko Mokubo, Keiichi Chin, Mitsuo Obana, Toshimasa Hishiki, Kouta Aoyama, Shinichi Nakajima, Shinichi Umezawa, Hidetoshi Shimura, Togo Aoyama, Masaaki Miyakawa   +24 more
doaj   +1 more source

Noninvasive Urinary Monitoring of Progression in IgA Nephropathy. [PDF]

, 2019
Standard methods for detecting and monitoring of IgA nephropathy (IgAN) have conventionally required kidney biopsies or suffer from poor sensitivity and specificity.
Fervenza, Fernando C, Lafayette, Richard A, Sarwal, Minnie M, Sarwal, Reuben D, Yang, Joshua YC   +4 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparison Of Oral Iron and Iv Iron Sucrose for Treatment of Anemia in Postpartum Indian Women

National Journal of Community Medicine, 2012
Objectives: To determine the efficacy of intravenous iron sucrose and oral iron in anaemic postpartum women, presenting at Institute of Kidney Disease and Research Centre. Method: Descriptive case series.
Aggarwal Rohina S, Mishra Vineet V, Panchal Navin A, Patel Nital H, Deshchougule Vrushali V, Jasani Anil F   +5 more
doaj  

Chronic Kidney Disease in Cats and the Risk of Total Hypercalcemia [PDF]

, 2017
BACKGROUND: Chronic kidney disease (CKD) is a common comorbidity in cats with hypercalcemia, but whether CKD is a risk factor for hypercalcemia is unclear.
Abdi, Andress, Barber, Barber, Barber, Berend, Berry, Bertazzolo, Bienzle, Blaine, Block, Burnell, Bushinsky, Chakrabarti, Cole, Costanzo, DiBartola, Elliott, Elliott, Eren, Finch, Flanders, Fogh-Andersen, Gal, Gauci, Geddes, Geddes, He, Jackson, Kelly, Kogika, Kovesdy, Kurz, Lemann, Levi, Levi, Lulich, Malatesha, Marino, Marone, McLeland, Meghji, Meuten, Midkiff, Must, Payne, Peacock, Picolos, Pieper, Piraino, Polzin, Rafferty, Savary, Schenck, Schenck, Schenck, Schenck, Schenck, Schenck, Schenck, Shanahan, Shipov, Sutton, Tentori, Williams, Yamada, Yang   +66 more
core   +2 more sources

Kidney diseases [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2021
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Dextromethorphan-induced serotonin syndrome leading to rhabdomyolysis and dialysis-requiring acute kidney injury: a case report and review

Renal Replacement Therapy
Background Dextromethorphan (DXM) misuse, particularly among young individuals, has risen owing to its euphoric and hallucinogenic effects. High-dose DXM ingestion can trigger serotonin syndrome, a condition characterized by psychiatric, neuromuscular ...
Kazuhiro Okamoto, Nobuhiro Hashimoto, Kaiya Ishizeki, Takamichi Nishimura, Shuzo Makino, Akito Takashima, Hiromitsu Miyakawa, Yoshiyasu Ueda, Terumasa Hayashi   +8 more
doaj   +1 more source