Results 41 to 50 of about 1,749,999 (379)

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in ...
Arcaro, Alexandre, Castelletti, Deborah, Fu, Xuebin, Liu, Yang, Mischak, Harald, Mullen, William, Pejchinovski, Martin, Serra, Andreas L., Siwy, Justyna, Wang, Xueqi, Watnick, Terry J.   +10 more
core   +2 more sources

Intradialytic hypotension is an important risk factor for critical limb ischemia in patients on hemodialysis

BMC Nephrology, 2019
Background Critical limb ischemia (CLI) and intradialytic hypotension (IDH) are common complications in patients on hemodialysis (HD). However, limited data are available on whether IDH is related to CLI in these patients.
Ryo Matsuura, Sumi Hidaka, Takayasu Ohtake, Yasuhiro Mochida, Kunihiro Ishioka, Kyoko Maesato, Machiko Oka, Hidekazu Moriya, Shuzo Kobayashi   +8 more
doaj   +1 more source

High prevalence of peripheral arterial disease (PAD) in incident hemodialysis patients: screening by ankle-brachial index (ABI) and skin perfusion pressure (SPP) measurement

Renal Replacement Therapy, 2018
Background Peripheral arterial disease (PAD) has much impact on mortality in hemodialysis (HD) patients. Ankle-brachial index (ABI) and skin perfusion pressure (SPP) are useful tools to detect PAD in HD patients.
Kunihiro Ishioka, Takayasu Ohtake, Hidekazu Moriya, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Sumi Hidaka, Shuzo Kobayashi   +7 more
doaj   +1 more source

The risk factors and predictive model for cardiac valve calcification in patients on maintenance peritoneal dialysis: a single-center retrospective study

Renal Failure, 2023
Background Cardiovascular calcification includes cardiac valve calcification (CVC) and vascular calcification. We aimed to analyze risk factors for CVC, and construct a predictive model in maintenance peritoneal dialysis (MPD) patients.Methods We ...
Yuxi Wang, Quanquan Shen, Junni Wang, Shilong Xiang, Yaomin Wang, Xiaohui Zhang, Jianghua Chen, Fei Han   +7 more
doaj   +1 more source

Effect of a reduction in glomerular filtration rate after nephrectomy on arterial stiffness and central hemodynamics: rationale and design of the EARNEST study [PDF]

, 2014
Background: There is strong evidence of an association between chronic kidney disease (CKD) and cardiovascular disease. To date, however, proof that a reduction in glomerular filtration rate (GFR) is a causative factor in cardiovascular disease is ...
Alam, Arena, Bahous, Benetos, Blacher, Blacher, Boudville, Briet, Charles J. Ferro, Charles R. Tomson, Chue, Chue, Daniel Zehnder, DeLoach, Doucende, Edwards, Eknoyan, Faul, Fehrman-Ekholm, Foley, Forbat, Frimodt-Moller, Garg, Go, Groenink, Grothues, Guerin, Hametner, Ian B. Wilkinson, Ibrahim, Jackson, John R. Cockcroft, Jonathan N. Townend, Kasiske, Krohn, Landray, Lang, Laurent, Laurie A. Tomlinson, Levey, Lewington, Luzardo, Maceira, Madero, Mafham, Mark, Martensson, Matsushita, Michels, Moody, Moody, Myerson, Nagueh, National Kidney Foundation, O'Brien, Patrick B. Mark, Richard P. Steeds, Rook, Rothwell, Savage, Schiffrin, Schiller, Segev, Tavakol, Townsend, Vickery, Wang, Wei, Weiss, Wiesmann, Wilkinson, William E. Moody, Yeon, Young   +73 more
core   +2 more sources

Polycystic kidney disease [PDF]

Nature Reviews Disease Primers, 2018
Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main forms of monogenic cystic kidney diseases.
Bergmann, C., Guay-Woodford, L.M., Harris, P.C., Horie, S., Peters, D.J.M., Torres, V.E.   +5 more
openaire   +5 more sources

Cilostazol-induced acute tubulointerstitial nephritis accompanied by IgA nephropathy: a case report

BMC Nephrology, 2018
Background Cilostazol is an antiplatelet drug that is widely prescribed for the prevention of secondary stroke. Adverse reactions to cilostazol include headaches, palpitations, and diarrhea. Little is known about the nephrotoxicity of cilostazol, such as
Hisato Shima, Manabu Tashiro, Satoshi Yamada, Motokazu Matsuura, Kazuyoshi Okada, Toshio Doi, Jun Minakuchi, Shu Kawashima   +7 more
doaj   +1 more source

Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]

, 2018
Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean, Halliday, Christopher, Jahagirdar, Ravi, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Robson, Richard, Stotz, Stephanie C, Sweeney, Michael, Tsujikawa, Laura M, Wasiak, Sylwia, Wong, Norman C   +11 more
core   +2 more sources

Systemic sclerosis complicated with renal thrombotic microangiopathy: a case report and literature review

BMC Nephrology, 2022
Background Systemic sclerosis (SSc) may overlap with other connective tissue diseases, which is named overlap syndrome. Scleroderma renal crisis (SRC) is a rare but severe complication of SSc.
Weiwei Kong, Yaomin Wang, Huiping Wang, Qin Zhou, Jianghua Chen, Fei Han   +5 more
doaj   +1 more source

Primary Renal Lymphoma Presenting as End-Stage Renal Disease. [PDF]

, 2017
Primary renal lymphoma is a rare entity, even more so in children. Children with primary renal lymphoma present with variable clinical features such as constitutional signs and symptoms, acute kidney injury, palpable abdominal masses, and gross hematuria.
Butani, Lavjay, Ducore, Jonathan
core   +3 more sources