Results 81 to 90 of about 1,749,999 (379)

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Polycystic Kidney Disease [PDF]

open access: yesNew England Journal of Medicine, 1989
The Polycystic Kidney Disease (PKD) is a genetic disease which is characterized by the gradual emergence of cystic lesions in the kidneys, which replace the renal parenchyma causing deterioration of its function to stage 5. The PKD is one of the causes of Chronic Kidney Disease on renal replacement therapy (RRT).
Lavie, C.J.   +3 more
openaire   +4 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

The impact of intravenous methylprednisolone pulses on renal survival in anti-neutrophil cytoplasmic antibody associated vasculitis with severe renal injury patients: a retrospective study

open access: yesBMC Nephrology, 2017
Background High-dose methylprednisolone pulses were one of the main treatments for anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitides (AAV) but had obvious side effects.
Yanhong Ma   +7 more
doaj   +1 more source

Predictors of culture-negative peritoneal dialysis-associated peritonitis: a single center, retrospective study

open access: yesRenal Replacement Therapy, 2023
Background Empirical antibiotic treatment against peritoneal dialysis (PD)-related peritonitis should be immediately initiated before PD effluent culture results are obtained.
Hisato Shima   +11 more
doaj   +1 more source

Cardiovascular morbidity and mortality after kidney transplantation [PDF]

open access: yes, 2014
Kidney transplantation is the optimal treatment for patients with end stage renal disease (ESRD) who would otherwise require dialysis. Patients with ESRD are at dramatically increased cardiovascular (CV) risk compared to the general population.
Jardine, Alan G.   +2 more
core   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

open access: yesMolecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian   +12 more
wiley   +1 more source

STXBP3 and GOT2 predict immunological activity in acute allograft rejection

open access: yesFrontiers in Immunology, 2022
BackgroundAcute allograft rejection (AR) following renal transplantation contributes to chronic rejection and allograft dysfunction. The current diagnosis of AR remains dependent on renal allograft biopsy which cannot immediately detect renal allograft ...
Qinfan Yao   +35 more
doaj   +1 more source

The Open Kidney Ultrasound Data Set [PDF]

open access: yesarXiv, 2022
Ultrasound, because of its low cost, non-ionizing, and non-invasive characteristics, has established itself as a cornerstone radiological examination. Research on ultrasound applications has also expanded, especially with image analysis with machine learning. However, ultrasound data are frequently restricted to closed data sets, with only a few openly
arxiv  

Leukotrienes and kidney diseases [PDF]

open access: yesCurrent Opinion in Nephrology and Hypertension, 2018
This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings.Since last reviewed in 1994, leukotrienes were shown to mediate drug ...
Efrat Dvash, Menachem Rubinstein
openaire   +3 more sources

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