Results 1 to 10 of about 11,405,950 (406)
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases [PDF]
Cell Death and Disease, 2023 Kidney diseases remain one of the leading causes of human death and have placed a heavy burden on the medical system. Regulated cell death contributes to the pathology of a plethora of renal diseases.
Jinghan Li +3 more
semanticscholar +2 more sources
Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases
International Journal on Biological Sciences, 2023 Ferroptosis is an iron-dependent programmed cell death pattern that is characterized by iron overload, reactive oxygen species (ROS) accumulation and lipid peroxidation.
Q. Feng +10 more
semanticscholar +1 more source
Signaling pathways of chronic kidney diseases, implications for therapeutics
Signal Transduction and Targeted Therapy, 2022 Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) deposition.
Q. Yuan, B. Tang, Chun Zhang
semanticscholar +1 more source
Gut Dysbiosis and Kidney Diseases
Frontiers in Medicine, 2022 Gut dysbiosis is defined as disorders of gut microbiota and loss of barrier integrity, which are ubiquitous on pathological conditions and associated with the development of various diseases.
C. Cao, Han Zhu, Ying Yao, R. Zeng
semanticscholar +1 more source
Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines
Frontiers in Pharmacology, 2022 Kidney injuries may trigger renal fibrosis and lead to chronic kidney disease (CKD), but effective therapeutic strategies are still limited. Quercetin is a natural flavonoid widely distributed in herbal medicines.
Yi-qin Chen +6 more
semanticscholar +1 more source
Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases
Biomolecules, 2021 Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced.
Ana Karina Aranda-Rivera +3 more
semanticscholar +1 more source
The Cross-Link between Ferroptosis and Kidney Diseases
Oxidative Medicine and Cellular Longevity, 2021 Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders of the kidney in various etiologies, which significantly affect human survival and social wealth.
Jingyu Wang, Yi Liu, Yaqing Wang, Li Sun
semanticscholar +1 more source
Estrogen and estrogen receptors in kidney diseases
Renal Failure, 2021 Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to global health within this century. Studies have suggested that estrogen and estrogen receptors (ERs) play important roles in many physiological processes in the kidney.
Hao-Yang Ma, Shuang Chen, Yang Du
semanticscholar +1 more source
Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
International Journal of Molecular Sciences, 2021 Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and ...
P. Hung +3 more
semanticscholar +1 more source
cGAS‒STING signaling and function in metabolism and kidney diseases
Journal of Molecular Cell Biology, 2021 The cyclic GMP‒AMP synthase (cGAS)‒stimulator of interferon genes (STING) signaling pathway senses the presence of cytosolic DNA and, in turn, triggers downstream signaling to induce the expression of inflammatory and type I interferon genes in immune ...
Juli Bai, Feng Liu
semanticscholar +1 more source