Results 111 to 120 of about 11,405,950 (406)

Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults

Frontiers in Nutrition
BackgroundIncreased arterial stiffness and low handgrip strength (HGS) are associated with poor health outcomes and are a severe health risk for older adults. However, there is limited evidence and mixed results on whether there is an association between
Yan He, Yan He, Yue Niu, Zhe Li, Ruimin Zhang, Ruimin Zhang, Yizhi Chen, Yizhi Chen, Zheyi Dong, Ying Zheng, Qian Wang, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Zhe Feng, Weiguang Zhang, Xiangmei Chen, Xiangmei Chen   +18 more
doaj   +1 more source

A flow cytometry approach reveals heterogeneity in conventional subsets of murine renal mononuclear phagocytes

Scientific Reports, 2021
Mononuclear phagocytes (MNPs) participate in inflammation and repair after kidney injury, reflecting their complex nature. Dissection into refined functional subunits has been challenging and would benefit understanding of renal pathologies.
Johannes Nordlohne, Ilona Hulsmann, Svenja Schwafertz, Jasmin Zgrajek, Manuel Grundmann, Sibylle von Vietinghoff, Frank Eitner, Michael S. Becker   +7 more
doaj   +1 more source

Incidence and Prognosis of Acute Kidney Diseases and Disorders Using an Integrated Approach to Laboratory Measurements in a Universal Health Care System

JAMA Network Open, 2019
Key Points Question Do the acute kidney diseases and disorders (AKD) criteria from the Kidney Disease: Improving Global Outcomes guidelines identify patients who do not meet existing criteria for chronic kidney disease (CKD) or acute kidney injury (AKI),
M. James, A. Levey, M. Tonelli, Zhi Tan, Rebecca Barry, N. Pannu, P. Ravani, S. Klarenbach, B. Manns, B. Hemmelgarn   +9 more
semanticscholar   +1 more source

Spotlight on Genetic Kidney Diseases: A Call for Drug Delivery and Nanomedicine Solutions [PDF]

, 2023
Noah Trac, Anisa Ashraf, Joshua Giblin, Supriya Prakash, Samir Mitragotri, Eun Ji Chung   +5 more
openalex   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Understanding autoimmune response after SARS-CoV-2 infection and the pathogenesis/mechanisms of long COVID

Medical Review
COVID-19 posed a major challenge to the healthcare system and resources worldwide. The popularization of vaccines and the adoption of numerous prevention and control measures enabled the gradual end of the COVID-19 pandemic.
Guo Ming, Shang Shunlai, Li Mengfei, Cai Guangyan, Li Ping, Chen Xiangmei, Li Qinggang   +6 more
doaj   +1 more source

Profiling and initial validation of urinary microRNAs as biomarkers in IgA nephropathy [PDF]

PeerJ, 2015
Background. MicroRNAs (miRNAs) have been found in virtually all body fluids and used successfully as biomarkers for various diseases. Evidence indicates that miRNAs have important roles in IgA nephropathy (IgAN), a major cause of renal failure.
Nannan Wang, Ru Bu, Zhiyu Duan, Xueguang Zhang, Pu Chen, Zuoxiang Li, Jie Wu, Guangyan Cai, Xiangmei Chen   +8 more
doaj   +2 more sources

Autophagy in Chronic Kidney Diseases

Cells, 2019
Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis.
Tien-An Lin, V. Wu, Chao-Yung Wang
semanticscholar   +1 more source

Monogenic Kidney Diseases in Kidney Transplantation

Kidney International Reports
Monogenic kidney diseases are involved in up to 15% of end-stage kidney diseases (ESKDs) in adults, and in 70 % of pediatric patients. When these disorders lead to kidney failure (KF), kidney transplantation (KT) is the preferred mode of replacement therapy.
Gillion, Valentine, Devresse, Arnaud, Olinger, Eric, Dahlqvist, Géraldine, Demoulin, Nathalie, Godefroid, Nathalie, Claes, Kathleen, Devuyst, Olivier, Kanaan, Nada   +8 more
openaire   +4 more sources

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source