Results 61 to 70 of about 11,405,950 (406)

The Complement C3a and C3a Receptor Pathway in Kidney Diseases

Frontiers in Immunology, 2020
The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Shuang Gao, Z. Cui, Ming-hui Zhao
semanticscholar   +1 more source

Polycystic Kidney Disease [PDF]

New England Journal of Medicine, 1989
The Polycystic Kidney Disease (PKD) is a genetic disease which is characterized by the gradual emergence of cystic lesions in the kidneys, which replace the renal parenchyma causing deterioration of its function to stage 5. The PKD is one of the causes of Chronic Kidney Disease on renal replacement therapy (RRT).
Lavie, C.J., Klein, A.L., Seward, J.B., Tajik, A.J.   +3 more
openaire   +3 more sources

The Emerging Role of Innate Immunity in Chronic Kidney Diseases

International Journal of Molecular Sciences, 2020
Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue fibrosis that finally results in an irreversible end-stage renal disease (ESRD).
P. Tang, Ying-ying Zhang, Max Kam-Kwan Chan, W. Lam, J. Chung, W. Kang, K. To, H. Lan, P. Tang   +8 more
semanticscholar   +1 more source

Efficacy and Safety of Daprodustat Vs rhEPO for Anemia in Patients With Chronic Kidney Disease: A Meta-Analysis and Trial Sequential Analysis

Frontiers in Pharmacology, 2022
Introduction: Daprodustat, a novel hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI), its efficacy and safety remain unclear. Thus, we conducted this meta-analysis aiming at investigating its efficacy and safety on the treatment of patients
Zhangning Fu, Zhangning Fu, Xiaodong Geng, Xiaodong Geng, Kun Chi, Kun Chi, Chengcheng Song, Chengcheng Song, Di Wu, Chao Liu, Chao Liu, Quan Hong, Quan Hong   +12 more
doaj   +1 more source

mTOR Signaling in Kidney Diseases.

Kidney360, 2020
The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase, is crucial in regulating cell growth, metabolism, proliferation, and survival. Under physiologic conditions, mTOR signaling maintains podocyte and tubular cell homeostasis.
Yuan Gui, C. Dai
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

MSCs-derived HGF alleviates senescence after AKI by modulating mitoSTAT3-controlled copper flux and respiration

Stem Cell Research & Therapy
Background Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) can reverse senescence after acute kidney injury (AKI) via maintaining mitochondrial homeostasis.
Kaiting Zhuang, Wenjuan Wang, Cheng Xu, Siyang Wang, Yuhao Chen, Yingjie Zhang, Yanjun Liang, Xumin Zheng, Xiangmei Chen, Zhe Feng, Guangyan Cai   +10 more
doaj   +1 more source

Association between sarcopenia and frailty in elderly patients with chronic kidney disease

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Frailty and sarcopenia are prevalent in chronic kidney disease (CKD) populations and could increase the risk for adverse health outcomes.
Che Wang, Xinru Guo, Xieguanxuan Xu, Shuang Liang, Wenling Wang, Fanglei Zhu, Siyang Wang, Jie Wu, Li Zhang, Xuefeng Sun, Xiangmei Chen, Guangyan Cai, The Chinese observational prospective study of ageing population with chronic kidney disease (C‐OPTION)   +12 more
doaj   +1 more source

Urinary peptide-based classifier CKD273: towards clinical application in chronic kidney disease [PDF]

, 2017
Capillary electrophoresis coupled with mass spectrometry (CE-MS) has been used as a platform for discovery and validation of urinary peptides associated with chronic kidney disease (CKD).
Mischak, Harald, Pontillo, Claudia
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source