Results 81 to 90 of about 4,640,867 (405)

Dynamics of neutralizing antibody responses to SARS-CoV-2 in patients with COVID-19: an observational study

Signal Transduction and Targeted Therapy, 2021
Our understanding of the protective immunity, particularly the long-term dynamics of neutralizing antibody (NAbs) response to SARS-CoV-2, is currently limited.
Xin Xu, Sheng Nie, Yanqun Wang, Quanxin Long, Hong Zhu, Xiaoyong Zhang, Jian Sun, Qinglang Zeng, Jincun Zhao, Li Liu, Ling Li, Ailong Huang, Jinlin Hou, Fan Fan Hou   +13 more
doaj   +1 more source

Histopathological Changes in the Kidney following Congestive Heart Failure by Volume Overload in Rats [PDF]

, 2017
Background. This study investigated histopathological changes and apoptotic factors that may be involved in the renal damage caused by congestive heart failure in a rat model of infrarenal aortocaval fistula (ACF). Methods.
Aboryag, Noureddin B., Dehe, Lukas, Mohamed, Doaa M., Mousa, Shaaban A., Schaefer, Michael, Shakibaei, Mehdi, Shaqura, Mohammed, Treskatsch, Sacha   +7 more
core   +4 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Mortality and Recovery Associated with Kidney Failure Due to Acute Kidney Injury.

American Society of Nephrology. Clinical Journal, 2020
BACKGROUND AND OBJECTIVES AKI requiring dialysis is a contributor to the growing burden of kidney failure, yet little is known about the frequency and patterns of recovery of AKI and its effect on outcomes in patients on incident dialysis.
Silvi Shah, A. Leonard, K. Harrison, K. Meganathan, A. Christianson, C. Thakar   +5 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Blood volume and chronic kidney disease in heart failure – Can volume expansion help balance the Cardio‐Renal Axis for better clinical outcomes? [PDF]

, 2022
Wayne L. Miller, Marat Fudim, Brian P. Mullan   +2 more
openalex   +1 more source

Association of Age With Risk of Kidney Failure in Adults With Stage IV Chronic Kidney Disease in Canada

JAMA Network Open, 2020
This cohort study examines the competing risks of death and kidney failure in an aging population with or without age-related comorbid conditions.
P. Ravani, R. Quinn, M. Fiocco, Ping Liu, H. Al-Wahsh, N. Lam, B. Hemmelgarn, B. Manns, M. James, Y. Joanette, M. Tonelli   +10 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Association of iron deficiency with kidney outcome and all-cause mortality in chronic kidney disease patients without anemia

Nutrition Journal
Background Iron deficiency is prevalent in patients with chronic kidney disease (CKD), even in those without anemia. However, the effects of iron deficiency on CKD progression and all-cause mortality in non-dialysis-dependent CKD (NDD-CKD) patients ...
Hongxue Yu, Xian Shao, Zhixin Guo, Mingzhen Pang, Shan Chen, Caoxiang She, Lisha Cao, Fan Luo, Ruixuan Chen, Shiyu Zhou, Xin Xu, Sheng Nie   +11 more
doaj   +1 more source

Association Between New-Onset Proteinuria During Hospitalization and Cardiovascular Mortality Among Patients With Atherosclerotic Cardiovascular Disease

JACC: Advances
Background: Evidence regarding the prognostic value of new-onset proteinuria during hospitalization among patients with atherosclerotic cardiovascular disease (ASCVD) is lacking.
Licong Su, MD, Ruixuan Chen, MD, Shiyu Zhou, MD, Zhixin Guo, MS, Yanqin Li, MD, Xiaodong Zhang, MD, Fan Luo, MD, Qi Gao, MD, Yuxin Lin, MD, Lisha Cao, MS, Jiao Liu, MS, Mingzhen Pang, MD, Caoxiang She, MS, Xin Xu, MD, Sheng Nie, MD   +14 more
doaj   +1 more source