Results 71 to 80 of about 911,122 (332)

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Impact of colloids or crystalloids in renal function assessed by NGAL and KIM-1 after hysterectomy: randomized controlled trial

Brazilian Journal of Anesthesiology, 2022
Background: Hydroxyethyl starches are colloids used in fluid therapy that may reduce volume infusion compared with crystalloids, but they can affect renal function in critical care patients. This study aims to assess renal effects of starches using renal
Murillo G. Santos, João Paulo Jordão Pontes, Saulo Gonçalves Filho, Rodrigo M. Lima, Murilo M. Thom, Norma Sueli P. Módolo, Daniela Ponce, Lais Helena Navarro   +7 more
doaj  

Kidney segmentation using 3D U-Net localized with Expectation Maximization [PDF]

, 2020
Kidney volume is greatly affected in several renal diseases. Precise and automatic segmentation of the kidney can help determine kidney size and evaluate renal function. Fully convolutional neural networks have been used to segment organs from large biomedical 3D images.
arxiv   +1 more source

Fluctuations of estimated glomerular filtration rate outside kidney disease improving global outcomes diagnostic criteria for acute kidney injury in end-stage liver disease outpatients and outcome postliver transplantation [PDF]

, 2017
Background. Renal dysfunction in end-stage liver disease (ESLD) results fromsystemic conditions that affect both liver and kidney with activation of vasoconstrictor systems.
Berloco, Pasquale Bartolomeo, Cappoli, Andrea, Fiacco, Federica, GINANNI CORRADINI, Stefano, Melandro, Fabio, Merli, Manuela, Mitterhofer, Anna Paola, Nofroni, Italo, Poli, Edoardo, Rossi, Massimo, Tinti, Francesca, Umbro, Ilaria, Zavatto, Assunta   +12 more
core   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Investigating the relationship between blood lead concentrations and kidney function tests in drug abusers admitted to Babol Hospital, Iran: A short report

Chronic Diseases Journal
BACKGROUND: The amount of impurity and addition of lead in drugs has grown increasingly. This study investigated the relationship between blood lead concentrations and kidney function tests.
Sahar Akbari-Kasgari, Iraj Javadi
doaj   +1 more source

Is surgical treatment necessary in all hydronephrotic kidney allografts? [PDF]

Vojnosanitetski Pregled, 2018
Background/Aim. The management of kidney graft hydronephrosis (KGH) is usually surgical, although some cases require expectant management and follow-up.
Topuzović Čedomir, Radovanović Milan N., Pejčić Tomislav   +2 more
doaj   +1 more source

The changing immunology of organ transplantation [PDF]

, 1995
The engrafted organ becomes a chimera as the recipient's leukocytes station themselves in the transplant. Remarkably, the recipient becomes chimeric as well, in a reverse migration involving immune cells from the graft.
Demetris AJ, Lu L, Lu L, Murase N, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Steinman RM, Streilein JW, Thomas JM   +10 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source